Hemoglobin Zurich

Common Name(s)

Hemoglobin Zurich

Hemoglobin (Hb) Zurich is an inherited blood disorder. People with Hb Zurich have an abnormal form of Hb, a red blood cell (RBC) protein that binds to oxygen in the lungs. This abnormal Hb more readily binds to carbon monoxide (producing carboxyhemoglobin or COHb). Normally the level of COHb is less than 1-2% in adults. People with Hb Zurich tend to have COHb levels above 3%. The health effects of Hb Zurich tend to be mild compared to other inherited blood cell disorders. Symptoms usually develop only when the body is stressed due to an infection or fever or when exposed to certain drugs. Symptoms develop as a result of the premature breakdown of RBC (hemolytic anemia). Click here to visit MedlinePlus.gov and view an illustration of hemoglobin.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemoglobin Zurich" for support, advocacy or research.

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American Sickle Cell Anemia Association

ASCAA is an organization that provides quality and comprehensive services through diagnostic testing, evaluation, couseling, and supportive services to individuals and families at-risk for sickle cell disease.

Last Updated: 1 Jun 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemoglobin Zurich" for support, advocacy or research.

Logo
American Sickle Cell Anemia Association

ASCAA is an organization that provides quality and comprehensive services through diagnostic testing, evaluation, couseling, and supportive services to individuals and families at-risk for sickle cell disease.

http://www.ascaa.org

Last Updated: 1 Jun 2015

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hemoglobin Zurich" returned 8 free, full-text research articles on human participants. First 3 results:

Studies on the oxidation of hemoglobin Zurich (beta 63 E7 Arg).
 

Author(s): E E Di Iorio, K H Winterhalter, A Mansouri, W E Blumberg, J Peisach

Journal: Eur. J. Biochem.. 1984 Dec;145(3):549-54.

 

Autoxidation and chemically-induced oxidation of hemoglobin Zurich (beta 63 E7 Arg) have been investigated by electron paramagnetic resonance and optical absorption spectroscopy. The results show that the replacement of the distal histidine of the hemoglobin beta chains by an arginine ...

Last Updated: 8 Feb 1985

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Nanosecond flash photolysis study of carbon monoxide binding to the beta chain of hemoglobin Zürich [beta 63(E7)His leads to Arg].
 

Author(s): D D Dlott, H Frauenfelder, P Langer, H Roder, E E DiIorio

Journal: Proc. Natl. Acad. Sci. U.S.A.. 1983 Oct;80(20):6239-43.

 

Binding of carbon monoxide to beta chains of hemoglobin Zürich has been studied by flash photolysis over the time range of nanoseconds to seconds at temperatures from 20 to 300 K. From 20 to 200 K a single rebinding process (process I) is seen, characterized by a distribution of ...

Last Updated: 23 Nov 1983

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First Japanese family with the unstable hemoglobin Zürich [beta 63(e7) His leads to Arg].
 

Author(s): K Murata, S Yamamoto, Y Hirano, M Omine, J Tsuchiya, Y Ohba, T Miyaji

Journal: Jpn. J. Med.. 1982 Jan;21(1):40-5.

 

Abnormal hemoglobin, which was latter identified as hemoglobin Zürich, was discovered in a 45-year-old female with severe valvular heart disease, congestive heart failure and moderate anemia and hyperbilirubinemia. Same abnormal hemoglobin was demonstrated in her two apparently healthy ...

Last Updated: 24 Jun 1982

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hemoglobin Zurich" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.