Factor VIII deficiency

Common Name(s)

Factor VIII deficiency, Hemophilia A, Classic hemophilia

Hemophilia A is a bleeding disorder that slows the blood clotting process. People with this disorder experience prolonged bleeding or oozing following an injury, surgery, or having a tooth pulled. In severe cases of hemophilia, heavy bleeding occurs after minor trauma or even in the absence of injury (spontaneous bleeding). Serious complications can result from bleeding into the joints, muscles, brain, or other internal organs. Milder forms of hemophilia do not involve spontaneous bleeding, and the disorder may not become apparent until abnormal bleeding occurs following surgery or a serious injury. Hemophilia A is inherited in an X-linked recessive fashion and is casued by mutations in the F8 gene.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Factor VIII deficiency" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Factor VIII deficiency" returned 44 free, full-text research articles on human participants. First 3 results:

A Hematological Menace: Multiple Venous Thrombosis Complicated by Acquired Factor VIII Deficiency.
 

Author(s): Robin Paudel, Luis W Dominguez, Prerna Dogra, Saurav Suman, Simon Badin, Carrie Wasserman

Journal:

 

Acquired hemophilia A (AHA) classically presents with spontaneous bleeding of mucosal sites, GI tract, and subcutaneous tissues, often leading to large hematomas and ecchymosis. Among documented cases, 50% are idiopathic and few have been associated with trauma or surgery. We present ...

Last Updated: 4 Apr 2016

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Acquired coagulant factor VIII deficiency induced by Bacillus anthracis lethal toxin in mice.
 

Author(s): Der-Shan Sun, Po-Chien Lee, Jyh-Hwa Kau, Yung-Luen Shih, Hsin-Hsien Huang, Chen-Ru Li, Chin-Cheng Lee, Yu-Ping Wu, Kuo-Ching Chen, Hsin-Hou Chang

Journal: Virulence. 2015 ;6(5):466-75.

 

Mice treated with anthrax lethal toxin (LT) exhibit hemorrhage caused by unknown mechanisms. Moreover, LT treatment in mice induced liver damage. In this study, we hypothesized that a suppressed coagulation function may be associated with liver damage, because the liver is the major ...

Last Updated: 9 Jul 2015

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Cerebral venous sinus thrombosis with increased factor VIII activity in an adult with iron deficiency anemia.
 

Author(s): Hiroshi Yokota, Yuki Ida, Shinya Sugiura, Ken Sasaki, Hiroo Itoh

Journal: Neurol India. ;62(6):674-5.

 

Last Updated: 16 Jan 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Factor VIII deficiency" returned 1 free, full-text review articles on human participants. First 3 results:

Comparison of the rates of joint arthroplasty in patients with severe factor VIII and IX deficiency: an index of different clinical severity of the 2 coagulation disorders.
 

Author(s): Giuseppe Tagariello, Alfonso Iorio, Elena Santagostino, Massimo Morfini, Ruggero Bisson, Massimo Innocenti, Maria Elisa Mancuso, Maria Gabriella Mazzucconi, Gian Luigi Pasta, Paolo Radossi, Giuseppina Rodorigo, Cristina Santoro, Roberto Sartori, Antonio Scaraggi, Luigi Pier Solimeno, Pier Mannuccio Mannucci,

Journal: Blood. 2009 Jul;114(4):779-84.

 

Data from the Italian Hemophilia Centres were collected to perform a retrospective survey of joint arthroplasty in patients with severe hemophilia. Twenty-nine of 49 hemophilia centers reported that 328 of the 347 operations were carried out in 253 patients with severe hemophilia ...

Last Updated: 24 Jul 2009

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pharmacokinetic Characterization of the Hemophilia A Population in Spain Using myPKFiT®
 

Status: Not yet recruiting

Condition Summary: Hemophilia A; Hemophilia; Factor VIII Deficiency

 

Last Updated: 2 Jan 2017

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Drug Use Investigation of Kovaltry in Hemophilia A Patients
 

Status: Recruiting

Condition Summary: Hemophilia A

 

Last Updated: 9 Aug 2017

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