Hemophilia B

Common Name(s)

Hemophilia B, Hereditary factor IX deficiency disease, Christmas disease

Hemophilia B is a bleeding disorder that slows the blood clotting process. People with this disorder experience prolonged bleeding or oozing following an injury or surgery. In severe cases of hemophilia, heavy bleeding occurs after minor trauma or even in the absence of injury. Serious complications can result from bleeding into the joints, muscles, brain, or other internal organs. Milder forms may not become apparent until abnormal bleeding occurs following surgery or a serious injury. People with an unusual form of hemophilia B, known as hemophilia B Leyden, experience episodes of excessive bleeding in childhood but have few bleeding problems after puberty. Hemophilia B is inherited in an X-linked recessive pattern and is caused by mutations in the F9 gene.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemophilia B" for support, advocacy or research.

Bleeding Disorders Alliance Illinois

The Bleeding Disorders Alliance Illinois exists to improve the quality of life for persons affected by hemophilia and other inherited bleeding disorders.

Last Updated: 25 Sep 2013

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Hemophilia Federation of America

The Hemophilia Federation of America is a national non-profit organization that assists and advocates for the bleeding disorders community.

Last Updated: 6 Jul 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemophilia B" for support, advocacy or research.

Bleeding Disorders Alliance Illinois

The Bleeding Disorders Alliance Illinois exists to improve the quality of life for persons affected by hemophilia and other inherited bleeding disorders.

http://www.bdai.org

Last Updated: 25 Sep 2013

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Hemophilia Federation of America

The Hemophilia Federation of America is a national non-profit organization that assists and advocates for the bleeding disorders community.

http://www.hemophiliafed.org

Last Updated: 6 Jul 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hemophilia B" returned 200 free, full-text research articles on human participants. First 3 results:

Repeated Diffuse Alveolar Hemorrhage in a Patient with Hemophilia B.
 

Author(s): Hajime Kasai, Jiro Terada, Hiromasa Hoshi, Takashi Urushibara, Fumiaki Kato, Rintaro Nishimura, Koichiro Tatsumi

Journal: Intern. Med.. 2017 ;56(4):425-428.

 

Diffuse alveolar hemorrhage (DAH) is a life-threatening complication that occurs in association with various diseases including coagulation disorders. In rare cases, it is caused by hemophilia. A 48-year-old man was admitted to our hospital for a third time due to DAH. Although the ...

Last Updated: 16 Feb 2017

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A new era for hemophilia B treatment.
 

Author(s): Jason A Taylor, Rebecca Kruse-Jarres

Journal: Blood. 2016 Apr;127(14):1734-6.

 

In this issue of Blood, Santagostino et al, in their phase 3 study, demonstrate efficacy and safety of recombinant fusion protein linking coagulation factor IX (FIX) with albumin (rIX-FP) which, along with the other 2 extended half-life FIX products, heralds a new era for the treatment ...

Last Updated: 8 Apr 2016

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[Economic impact of hemophilia type A and B in Mexico].
 

Author(s): Fernando Carlos-Rivera, Ricardo Gasca-Pineda, Abraham Majluf-Cruz, Jaime García-Chávez

Journal: Gac Med Mex. ;152(1):19-29.

 

The treatment of hemophilia generates a disproportionally large economic impact relative to its prevalence.

Last Updated: 1 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hemophilia B" returned 9 free, full-text review articles on human participants. First 3 results:

Transforming the treatment for hemophilia B patients: update on the clinical development of recombinant fusion protein linking recombinant coagulation factor IX with recombinant albumin (rIX-FP).
 

Author(s): Elena Santagostino

Journal: Thromb. Res.. 2016 May;141 Suppl 3():S5-8.

 

Recombinant fusion protein linking recombinant coagulation factor IX with recombinant albumin (rIX-FP; Idelvion®(†)) is an innovative new treatment designed to extend the half-life of factor IX (FIX) and ease the burden of care for hemophilia B patients. The rIX-FP clinical development ...

Last Updated: 11 Jun 2016

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Gene therapy in an era of emerging treatment options for hemophilia B.
 

Author(s): P E Monahan

Journal: J. Thromb. Haemost.. 2015 Jun;13 Suppl 1():S151-60.

 

Factor IX deficiency (hemophilia B) is less common than factor VIII deficiency (hemophilia A), and innovations in therapy for hemophilia B have generally lagged behind those for hemophilia A. Recently, the first sustained correction of the hemophilia bleeding phenotype by clotting ...

Last Updated: 7 Jul 2015

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Hemophilia B: molecular pathogenesis and mutation analysis.
 

Author(s): A C Goodeve

Journal: J. Thromb. Haemost.. 2015 Jul;13(7):1184-95.

 

Hemophilia B is an X-chromosome-linked inherited bleeding disorder primarily affecting males, but those carrier females with reduced factor IX activity (FIX:C) levels may also experience some bleeding. Genetic analysis has been undertaken for hemophilia B since the mid-1980s, through ...

Last Updated: 7 Jul 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 29 Nov 2016

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Last Updated: 10 Apr 2017

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