Heparin induced thrombocytopenia

Common Name(s)

Heparin induced thrombocytopenia

Heparin-induced thrombocytopenia (HIT) is an adverse reaction to the drug heparin resulting in an abnormally low amount of platelets (thrombocytopenia). HIT is usually an immune response which typically occurs 4-10 days after exposure to heparin; it can lead to serious complications and be life-threatening. This condition occurs in up to 5% of those who are exposed to heparin. Characteristic signs of HIT are a drop in platelet count of  greater than 50% and/or the formation of new blood clots during heparin therapy.  The first step of treatment is to discontinue and avoid all heparin products immediately. Often, affected individuals require another medicine to prevent blood clotting (anticoagulants).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Heparin induced thrombocytopenia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Heparin induced thrombocytopenia" returned 330 free, full-text research articles on human participants. First 3 results:

Fondaparinux in a critically Ill patient with heparin-induced thrombocytopenia: A case report.
 

Author(s): Yumiao He, Huaiwu He, Dawei Liu, Yun Long, Longxiang Su, Wei Cheng

Journal: Medicine (Baltimore). 2018 Sep;97(37):e12236.

 

Fondaparinux, as a factor Xa-inhibitor, is used off label to manage heparin-induced thrombocytopenia (HIT), but little experience with HIT patients has been reported in the literature. Moreover, the use of fondaparinux for full anticoagulation in critically ill patients with HIT and ...

Last Updated: 31 Dec 1969

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Intravenous Immune Globulin to Prevent Heparin-Induced Thrombocytopenia.
 

Author(s): Theodore E Warkentin, Troy H Climans, Pierre-Aurèle Morin

Journal: N. Engl. J. Med.. 2018 05;378(19):1845-1848.

 

Last Updated: 31 Dec 1969

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Is There an Association Between Heparin-Induced Thrombocytopenia (HIT) and Autoimmune Disease?
 

Author(s): Brent Klinkhammer, Michael Gruchalla

Journal: WMJ. 2018 Mar;117(1):13-17.

 

Heparin-induced thrombocytopenia (HIT) is a drug-induced, immunoglobulin G medicated autoimmune disorder associated with several negative clinical outcomes including increased morbidity, mortality, and increased medical costs. Previous studies have shown associations between comorbid ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Heparin induced thrombocytopenia" returned 59 free, full-text review articles on human participants. First 3 results:

The Role of Single-Molecule Force Spectroscopy in Unraveling Typical and Autoimmune Heparin-induced Thrombocytopenia.
 

Author(s): Van-Chien Bui, Thi-Huong Nguyen

Journal:

 

For the last two decades, heparins have been widely used as anticoagulants. Besides numerous advantages, up to 5% patients with heparin administration suffer from a major adverse drug effect known as heparin-induced thrombocytopenia (HIT). This typical HIT can result in deep vein ...

Last Updated: 31 Dec 1969

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Heparin-Induced Thrombocytopenia in Cardiac Surgery Patients.
 

Author(s): Allyson M Pishko, Adam Cuker

Journal: Semin. Thromb. Hemost.. 2017 Oct;43(7):691-698.

 

Last Updated: 31 Dec 1969

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Heparin-induced thrombocytopenia.
 

Author(s): Gowthami M Arepally

Journal: Blood. 2017 05;129(21):2864-2872.

 

Heparin-induced thrombocytopenia (HIT) is an immune complication of heparin therapy caused by antibodies to complexes of platelet factor 4 (PF4) and heparin. Pathogenic antibodies to PF4/heparin bind and activate cellular FcγRIIA on platelets and monocytes to propagate a hypercoagulable ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Efficacy and Safety of Apixaban in the Treatment of Heparin Induced Thrombocytopenia (HIT)
 

Status: Not yet recruiting

Condition Summary: Heparin-induced Thrombocytopenia; Heparin-induced Thrombocytopenia and Thrombosis

 

Last Updated: 14 Sep 2018

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Pharmacogenomics of Heparin-Induced Thrombocytopenia
 

Status: Recruiting

Condition Summary: Heparin-induced Thrombocytopenia

 

Last Updated: 26 Jan 2018

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Last Updated: 14 Aug 2018

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