Heparin induced thrombocytopenia

Common Name(s)

Heparin induced thrombocytopenia

Heparin-induced thrombocytopenia (HIT) is an adverse reaction to the drug heparin resulting in an abnormally low amount of platelets (thrombocytopenia). HIT is usually an immune response which typically occurs 4-10 days after exposure to heparin; it can lead to serious complications and be life-threatening. This condition occurs in up to 5% of those who are exposed to heparin. Characteristic signs of HIT are a drop in platelet count of  greater than 50% and/or the formation of new blood clots during heparin therapy.  The first step of treatment is to discontinue and avoid all heparin products immediately. Often, affected individuals require another medicine to prevent blood clotting (anticoagulants).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Heparin induced thrombocytopenia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Heparin induced thrombocytopenia" returned 332 free, full-text research articles on human participants. First 3 results:

Intravenous Immune Globulin to Prevent Heparin-Induced Thrombocytopenia.
 

Author(s): Theodore E Warkentin, Troy H Climans, Pierre-Aurèle Morin

Journal: N. Engl. J. Med.. 2018 05;378(19):1845-1848.

 

Last Updated: 31 Dec 1969

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[Treatment of heparin-induced thrombocytopenia with rivaroxaban. Case report].
 

Author(s): Gustavo Rivera O, Oscar Corsi S, Andrés Pavlovic J, Andrés Aizman S, Pablo Varas A

Journal: Rev Med Chil. 2017 Sep;145(9):1213-1217.

 

Heparin-induced thrombocytopenia (HIT) is immune-mediated. It occurs more frequently with unfractionated heparin (UFH) than with low molecular weight heparins (LMWH). It is associated with thromboembolic rather than hemorrhagic events, as opposed to thrombocytopenia of other etiologies. ...

Last Updated: 31 Dec 1969

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Argatroban for Heparin-Induced Thrombocytopenia during Venovenous Extracorporeal Membrane Oxygenation with Continuous Venovenous Hemofiltration.
 

Author(s): Jonathan H Sin, Natasha D Lopez

Journal: J Extra Corpor Technol. 2017 06;49(2):115-120.

 

Patients receiving extracorporeal membrane oxygenation (ECMO) are at risk of circuit thrombosis due to constant contact between blood and the extracorporeal components. Unfractionated heparin has traditionally been used in this setting as a systemic form of anticoagulation to prevent ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Heparin induced thrombocytopenia" returned 58 free, full-text review articles on human participants. First 3 results:

Heparin-induced thrombocytopenia.
 

Author(s): Gowthami M Arepally

Journal: Blood. 2017 05;129(21):2864-2872.

 

Heparin-induced thrombocytopenia (HIT) is an immune complication of heparin therapy caused by antibodies to complexes of platelet factor 4 (PF4) and heparin. Pathogenic antibodies to PF4/heparin bind and activate cellular FcγRIIA on platelets and monocytes to propagate a hypercoagulable ...

Last Updated: 31 Dec 1969

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Functional Assays in the Diagnosis of Heparin-Induced Thrombocytopenia: A Review.
 

Author(s): Valentine Minet, Jean-Michel Dogné, François Mullier

Journal:

 

A rapid and accurate diagnosis in patients with suspected heparin-induced thrombocytopenia (HIT) is essential for patient management but remains challenging. Current HIT diagnosis ideally relies on a combination of clinical information, immunoassay and functional assay results. Platelet ...

Last Updated: 31 Dec 1969

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Diagnostic accuracy of IgG-specific versus polyspecific enzyme-linked immunoassays in heparin-induced thrombocytopenia: a systematic review and meta-analysis.
 

Author(s): H D Husseinzadeh, P A Gimotty, A M Pishko, M Buckley, T E Warkentin, A Cuker

Journal: J. Thromb. Haemost.. 2017 06;15(6):1203-1212.

 

Essentials Immunoassay specificity varies in heparin-induced thrombocytopenia (HIT) testing. This meta-analysis examined 9 studies that tested samples by both IgG and polyspecific methods. IgG-specific assays confer superior diagnostic accuracy compared with polyspecific assays. These ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Efficacy and Safety of Apixaban in the Treatment of Heparin Induced Thrombocytopenia (HIT)
 

Status: Not yet recruiting

Condition Summary: Heparin-induced Thrombocytopenia; Heparin-induced Thrombocytopenia and Thrombosis

 

Last Updated: 19 Jul 2018

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Pharmacogenomics of Heparin-Induced Thrombocytopenia
 

Status: Recruiting

Condition Summary: Heparin-induced Thrombocytopenia

 

Last Updated: 26 Jan 2018

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Last Updated: 9 May 2017

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