Heparin induced thrombocytopenia

Common Name(s)

Heparin induced thrombocytopenia

Heparin-induced thrombocytopenia (HIT) is an adverse reaction to the drug heparin resulting in an abnormally low amount of platelets (thrombocytopenia). HIT is usually an immune response which typically occurs 4-10 days after exposure to heparin; it can lead to serious complications and be life-threatening. This condition occurs in up to 5% of those who are exposed to heparin. Characteristic signs of HIT are a drop in platelet count of  greater than 50% and/or the formation of new blood clots during heparin therapy.  The first step of treatment is to discontinue and avoid all heparin products immediately. Often, affected individuals require another medicine to prevent blood clotting (anticoagulants).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Heparin induced thrombocytopenia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Heparin induced thrombocytopenia" returned 321 free, full-text research articles on human participants. First 3 results:

Rapid immunoassays for diagnosis of heparin-induced thrombocytopenia: Comparison of diagnostic accuracy, reproducibility, and costs in clinical practice.
 

Author(s): Andriyana Bankova, Yvonne Andres, Michael P Horn, Lorenzo Alberio, Michael Nagler

Journal:

 

Immunoassays are crucial in the work-up of patients with suspected heparin-induced thrombocytopenia (HIT) and rapid tests have been recently developed. However, comparative data on diagnostic accuracy, reproducibility, and analytical costs of different immunoassays in clinical practice are limited.

Last Updated: 8 Jun 2017

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Heparin-induced thrombocytopenia as a cause of prolonged low platelet count in a patient with thrombotic thrombocytopenic purpura treated with plasmapheresis.
 

Author(s): Agata Winiarska, Norbert Kwella, Tomasz Stompór

Journal: Acta Biochim. Pol.. 2017 ;64(2):375-376.

 

Thrombotic thrombocytopenic purpura (TTP) is a rare disorder belonging to thrombotic microangiopathies (TMA) and is caused by functional deficiency of the ADAMTS-13 metalloproteinase. Plasma exchange (PE) remains the treatment of choice in this disease. Here, were describe the case ...

Last Updated: 5 Apr 2017

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Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia.
 

Author(s): Vincent Hayes, Ian Johnston, Gowthami M Arepally, Steven E McKenzie, Douglas B Cines, Lubica Rauova, Mortimer Poncz

Journal: J. Clin. Invest.. 2017 Mar;127(3):1090-1098.

 

Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder initiated by antibodies against complexes between human platelet factor 4 (hPF4) and heparin. A better understanding of the events that initiate the prothrombotic state may improve approaches to antithrombotic management. ...

Last Updated: 20 Feb 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Heparin induced thrombocytopenia" returned 52 free, full-text review articles on human participants. First 3 results:

Functional Assays in the Diagnosis of Heparin-Induced Thrombocytopenia: A Review.
 

Author(s): Valentine Minet, Jean-Michel Dogné, François Mullier

Journal:

 

A rapid and accurate diagnosis in patients with suspected heparin-induced thrombocytopenia (HIT) is essential for patient management but remains challenging. Current HIT diagnosis ideally relies on a combination of clinical information, immunoassay and functional assay results. Platelet ...

Last Updated: 11 Apr 2017

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[Heparin-induced thrombocytopenia. New therapeutical options].
 

Author(s): Carina E Seculini Patiño, Aldo H Tabares

Journal: Medicina (B Aires). ;76(4):230-4.

 

Heparin-induced thrombocytopenia (HIT) is an immune-mediated adverse reaction due to antibodies to a multimolecular complex of heparin and platelet factor 4 (PF4) characterized by moderate thrombocytopenia and paradoxical arterial or venous thrombosis. It is a relatively infrequent ...

Last Updated: 31 Aug 2016

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Heparin-Induced Thrombocytopenia: A Comprehensive Clinical Review.
 

Author(s): Benjamin S Salter, Menachem M Weiner, Muoi A Trinh, Joshua Heller, Adam S Evans, David H Adams, Gregory W Fischer

Journal: J. Am. Coll. Cardiol.. 2016 May;67(21):2519-32.

 

Heparin-induced thrombocytopenia is a profoundly dangerous, potentially lethal, immunologically mediated adverse drug reaction to unfractionated heparin or, less commonly, to low-molecular weight heparin. In this comprehensive review, the authors highlight heparin-induced thrombocytopenia's ...

Last Updated: 27 May 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pharmacogenomics of Heparin-Induced Thrombocytopenia
 

Status: Recruiting

Condition Summary: Heparin-induced Thrombocytopenia

 

Last Updated: 31 Jul 2017

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Last Updated: 9 May 2017

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Optimizing the Diagnosis of Heparin Induced Thrombocytopenia
 

Status: Not yet recruiting

Condition Summary: Heparin-induced Thrombocytopenia (HIT)

 

Last Updated: 8 May 2017

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