Hepatic encephalopathy

Common Name(s)

Hepatic encephalopathy

Hepatic encephalopathy is a syndrome observed in some patients with cirrhosis. It is defined as a spectrum of neuropsychiatric abnormalities in patients with liver dysfunction, when other known brain disease has been excluded.  Signs and symptoms may be debilitating, and they can begin mildly and gradually, or occur suddenly and severely. They may include personality or mood changes, intellectual impairment, abnormal movements, a depressed level of consciousness, and other symptoms.  There are several theories regarding the exact cause, but development of the condition is probably at least partially due to the effect of substances that are toxic to nerve tissue (neurotoxic), which are typically present with liver damage and/or liver disease. Treatment depends upon the severity of mental status changes and upon the certainty of the diagnosis.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hepatic encephalopathy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hepatic encephalopathy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hepatic encephalopathy" returned 297 free, full-text research articles on human participants. First 3 results:

Hepatic Encephalopathy.
 

Author(s): Eelco F M Wijdicks

Journal: N. Engl. J. Med.. 2017 01;376(2):186.

 

Last Updated: 11 Jan 2017

Go To URL
A potential impact of Helicobacter pylori infection on minimal hepatic encephalopathy pathobiology.
 

Author(s): Jannis Kountouras, Stergios A Polyzos, Emmanuel Gavalas, Marina Boziki, Panagiotis Katsinelos, Christos Zeglinas, Elizabeth Vardaka, Constantinos Kountouras, Ioannis Venizelos, Sotiris Anastasiadis, Georgia Deretzi

Journal: J Gastrointestin Liver Dis. 2016 Sep;25(3):405-6.

 

Last Updated: 30 Sep 2016

Go To URL
Epilepsy as a risk factor for hepatic encephalopathy in patients with cirrhosis: a cohort study.
 

Author(s): Peter Jepsen, Jakob Christensen, Karin Weissenborn, Hugh Watson, Hendrik Vilstrup

Journal:

 

Epilepsy is associated with an increased mortality among cirrhosis patients, but the reasons are unknown. We aimed to determine whether epilepsy is a risk factor for developing hepatic encephalopathy (HE), which is a strong predictor of mortality.

Last Updated: 26 Jul 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hepatic encephalopathy" returned 61 free, full-text review articles on human participants. First 3 results:

Efficacy of lactulose in the prophylaxis of hepatic encephalopathy in cirrhotic patients presenting gastrointestinal bleeding.
 

Author(s): Felipe Toyama Aires, Paola Teruya Ramos, Wanderley Marques Bernardo

Journal: Rev Assoc Med Bras (1992). ;62(3):243-7.

 

Hepatic encephalopathy (HE) is a bad prognostic factor in patients with liver cirrhosis and its incidence is associated with several triggering factors being the most prevalent gastrointestinal bleeding. Lactulose, despite its questionable efficacy in the literature, is considered ...

Last Updated: 17 Jun 2016

Go To URL
How to diagnose and manage hepatic encephalopathy: a consensus statement on roles and responsibilities beyond the liver specialist.
 

Author(s): Debbie L Shawcross, Arthur A Dunk, Rajiv Jalan, Gerald Kircheis, Robert J de Knegt, Wim Laleman, John K Ramage, Heiner Wedemeyer, Ian E J Morgan,

Journal: Eur J Gastroenterol Hepatol. 2016 Feb;28(2):146-52.

 

Hepatic encephalopathy is defined as brain dysfunction caused by liver insufficiency and/or portosystemic shunting. Symptoms include nonspecific cognitive impairment, personality changes and changes in consciousness. Overt (symptomatic) hepatic encephalopathy is a common complication ...

Last Updated: 23 Dec 2015

Go To URL
Inflammation: A novel target of current therapies for hepatic encephalopathy in liver cirrhosis.
 

Author(s): Ming Luo, Jian-Yang Guo, Wu-Kui Cao

Journal: World J. Gastroenterol.. 2015 Nov;21(41):11815-24.

 

Hepatic encephalopathy (HE) is a severe neuropsychiatric syndrome that most commonly occurs in decompensated liver cirrhosis and incorporates a spectrum of manifestations that ranges from mild cognitive impairment to coma. Although the etiology of HE is not completely understood, ...

Last Updated: 11 Nov 2015

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 21 Dec 2016

Go to URL
Fecal Microbiota Transplantation (FMT) in the Management of Hepatic Encephalopathy (HE): a Pilot Study
 

Status: Recruiting

Condition Summary: Hepatic Encephalopathy

 

Last Updated: 12 Jan 2017

Go to URL
Real World Outcomes Study of Hepatic Encephalopathy Patients' Experience on Rifaximin (PROSPER)
 

Status: Recruiting

Condition Summary: Hepatic Encephalopathy

 

Last Updated: 10 Dec 2015

Go to URL