Hepatic encephalopathy

Common Name(s)

Hepatic encephalopathy

Hepatic encephalopathy is a syndrome observed in some patients with cirrhosis. It is defined as a spectrum of neuropsychiatric abnormalities in patients with liver dysfunction, when other known brain disease has been excluded.  Signs and symptoms may be debilitating, and they can begin mildly and gradually, or occur suddenly and severely. They may include personality or mood changes, intellectual impairment, abnormal movements, a depressed level of consciousness, and other symptoms.  There are several theories regarding the exact cause, but development of the condition is probably at least partially due to the effect of substances that are toxic to nerve tissue (neurotoxic), which are typically present with liver damage and/or liver disease. Treatment depends upon the severity of mental status changes and upon the certainty of the diagnosis.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hepatic encephalopathy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hepatic encephalopathy" returned 298 free, full-text research articles on human participants. First 3 results:

Hepatic Encephalopathy.
 

Author(s): Eelco F M Wijdicks

Journal: N. Engl. J. Med.. 2017 01;376(2):186.

 

Last Updated: 11 Jan 2017

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Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis.
 

Author(s): Astrid Ruiz-Margáin, Ricardo Ulises Macías-Rodríguez, Javier Ampuero, Francisco Javier Cubero, Luis Chi-Cervera, Silvia L Ríos-Torres, Andrés Duarte-Rojo, Ángeles Espinosa-Cuevas, Manuel Romero-Gómez, Aldo Torre

Journal: World J. Gastroenterol.. 2016 Dec;22(45):10064-10070.

 

Evaluate the association between phase angle and the development of hepatic encephalopathy in the long-term follow-up of cirrhotic patients.

Last Updated: 26 Dec 2016

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Magnetic Resonance Spectroscopy for Evaluating Portal-Systemic Encephalopathy in Patients with Chronic Hepatic Schistosomiasis Japonicum.
 

Author(s): Ying Li, Lihong Mei, Jinwei Qiang, Shuai Ju, Shuhui Zhao

Journal:

 

Portal-systemic encephalopathy (PSE) is classified as type B hepatic encephalopathy. Portal-systemic shunting rather than liver dysfunction is the main cause of PSE in chronic hepatic schistosomiasis japonicum (HSJ) patients. Owing to lack of detectable evidence of intrinsic liver ...

Last Updated: 15 Dec 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hepatic encephalopathy" returned 64 free, full-text review articles on human participants. First 3 results:

Association between proton pump inhibitors and hepatic encephalopathy: A meta-analysis.
 

Author(s): Jin Bian, Anqiang Wang, Jianzhen Lin, Liangcai Wu, Hanchun Huang, Shanshan Wang, Xiaobo Yang, Xin Lu, Yiyao Xu, Haitao Zhao

Journal: Medicine (Baltimore). 2017 Apr;96(17):e6723.

 

Several studies have shown that proton pump inhibitors (PPIs) use can increase the risk of developing hepatic encephalopathy (HE) in patients with liver dysfunction. However, no definite conclusion is drawn because of study design limitations. Therefore, we conducted a meta-analysis ...

Last Updated: 26 Apr 2017

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Hyperammonemic coma after craniotomy: Hepatic encephalopathy from upper gastrointestinal hemorrhage or valproate side effect?: Case report and literature review.
 

Author(s): Xiaopeng Guo, Junji Wei, Lu Gao, Bing Xing, Zhiqin Xu

Journal: Medicine (Baltimore). 2017 Apr;96(15):e6588.

 

Postoperative coma is not uncommon in patients after craniotomy. It generally presents as mental state changes and is usually caused by intracranial hematoma, brain edema, or swelling. Hyperammonemia can also result in postoperative coma; however, it is rarely recognized as a potential ...

Last Updated: 13 Apr 2017

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Hepatic encephalopathy: Ever closer to its big bang.
 

Author(s): Pablo A Souto, Ariel R Marcotegui, Lisandro Orbea, Juan Skerl, Juan Carlos Perazzo

Journal: World J. Gastroenterol.. 2016 Nov;22(42):9251-9256.

 

Hepatic encephalopathy (HE) is a neuropsychiatric disorder that commonly complicates the course of patients with liver disease. Despite the fact that the syndrome was probably first recognized hundreds of years ago, the exact pathogenesis still remains unclear. Minimal hepatic encephalopathy ...

Last Updated: 29 Nov 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Low-dose Rifaximin in the Treatment of Covert Hepatic Encephalopathy
 

Status: Not yet recruiting

Condition Summary: Covert Hepatic Encephalopathy

 

Last Updated: 6 Mar 2017

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Last Updated: 26 Apr 2017

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PEG (Polyethylene Glycol)Versus Lactulose For Treatment Of Overt Hepatic Encephalopathy
 

Status: Recruiting

Condition Summary: Hepatic Encephalopathy

 

Last Updated: 25 Apr 2017

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