Hepatitis B

Common Name(s)

Hepatitis B

Hepatitis B is a viral hepatitis that affects the liver and is caused by the hepatitis B virus, or HBV. The liver is an organ found on the right side of our belly (abdomen) under the rib cage. It cleans our blood of toxins, poisons, and bacteria. It produces bile which helps our body breakdown food. Hepatitis B occurs when HBV causes a person’s immune system to attack the liver. Symptoms may be mild to severe and may include nausea, diarrhea, fatigue, and jaundice (yellowing of the skin). Usually the body is able to fight the infection within 6 months (acute infection). Chronic HBV infections may lead to liver cancer, permanent scarring of the liver (cirrhosis), or liver failure. It is rare for HBV to become chronic in adults, but 80% of infected newborns and 20% of infected children under 5 develop a chronic infection. HBV is spread from person to person through blood, semen or other body fluids. The most common ways to get infected by HBV are through sexual contact with someone who has HBV, sharing of infected needles (usually during IV drug use), accidental needle sticks to health care workers working with patients who have HBV, and mother to child during childbirth if the mother has HBV.

A vaccine is available to prevent HBV infection. The vaccine may even be given to newborns exposed to HBV during childbirth to successfully prevent infection. It is important to call your physician within 12 hours if you know you have been exposed to HBV and are not vaccinated. There are treatments available to decrease your chance of becoming infected. If the condition becomes chronic, there are medications available to help slow the damage to the liver but there is no cure at this time. HBV infections are diagnosed through blood tests and possibly liver biopsies. Talk with your doctor if you or a family member has been diagnosed with hepatitis B. Support groups are also good resources of support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hepatitis B" for support, advocacy or research.

Hepatitis Foundation International

Hepatitis Foundation International is dedicated to promoting wellness and healthy lifestyles for all individuals in order to reduce the incidence of preventable diseases that affect the liver’s health including: obesity, diabetes, fatty liver, high cholesterol, cardiovascular disease, hepatitis, HIV/AIDS, and substance abuse. We inform, educate, and empower by making available reliable and up-to-date information.

Last Updated: 23 Feb 2015

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American Liver Foundation

The American Liver Foundation (ALF) is the nation's leading nonprofit organization promoting liver health and disease prevention. ALF provides research, education and advocacy for those affected by liver-related diseases, including hepatitis.

Last Updated: 27 Nov 2012

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The STD Project

Established in April of 2012 during STD Awareness Month, The STD Project is a multi-award-winning independent website and progressive movement eradicating STD stigma by facilitating and encouraging awareness, education, and acceptance through story-telling and resource recommendations. We are taking steps toward modern-day sexual health and prevention by advocating for conscientious and informed decisions.

Last Updated: 11 Jul 2016

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World Hepatitis Alliance

The World Hepatitis Alliance is a not-for-profit international umbrella NGO. Our membership is composed of over 170 organisations who work in the field of viral hepatitis, representing every region of the world. We are patient-led and patient-driven, and in this way, we are the global voice for the 500 million people worldwide living with viral hepatitis. Through better awareness, prevention, care, support and access to treatment, our ultimate goal is to work with governments to eradicate these diseases from the planet.

Last Updated: 15 Apr 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hepatitis B" for support, advocacy or research.

Hepatitis Foundation International

Hepatitis Foundation International is dedicated to promoting wellness and healthy lifestyles for all individuals in order to reduce the incidence of preventable diseases that affect the liver’s health including: obesity, diabetes, fatty liver, high cholesterol, cardiovascular disease, hepatitis, HIV/AIDS, and substance abuse. We inform, educate, and empower by making available reliable and up-to-date information.

http://www.HepatitisFoundation.org

Last Updated: 23 Feb 2015

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American Liver Foundation

The American Liver Foundation (ALF) is the nation's leading nonprofit organization promoting liver health and disease prevention. ALF provides research, education and advocacy for those affected by liver-related diseases, including hepatitis.

http://www.liverfoundation.org

Last Updated: 27 Nov 2012

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The STD Project

Established in April of 2012 during STD Awareness Month, The STD Project is a multi-award-winning independent website and progressive movement eradicating STD stigma by facilitating and encouraging awareness, education, and acceptance through story-telling and resource recommendations. We are taking steps toward modern-day sexual health and prevention by advocating for conscientious and informed decisions.

http://www.thestdproject.com/

Last Updated: 11 Jul 2016

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World Hepatitis Alliance

The World Hepatitis Alliance is a not-for-profit international umbrella NGO. Our membership is composed of over 170 organisations who work in the field of viral hepatitis, representing every region of the world. We are patient-led and patient-driven, and in this way, we are the global voice for the 500 million people worldwide living with viral hepatitis. Through better awareness, prevention, care, support and access to treatment, our ultimate goal is to work with governments to eradicate these diseases from the planet.

http://www.worldhepatitisalliance.org/en/

Last Updated: 15 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hepatitis B" returned 7884 free, full-text research articles on human participants. First 3 results:

Hepatitis B virus infection in undocumented immigrants and refugees in Southern Italy: demographic, virological, and clinical features.
 

Author(s): Nicola Coppola, Loredana Alessio, Luciano Gualdieri, Mariantonietta Pisaturo, Caterina Sagnelli, Carmine Minichini, Giovanni Di Caprio, Mario Starace, Lorenzo Onorato, Giuseppe Signoriello, Margherita Macera, Italo Francesco Angelillo, Giuseppe Pasquale, Evangelista Sagnelli

Journal:

 

The data on hepatitis b virus (HBV) infection in immigrants population are scanty. The porpoise of this study was to define the demographic, virological, and clinical characteristics of subjects infected with HBV chronic infection in a cohort of immigrants living in Naples, Italy.

Last Updated: 9 Feb 2017

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Comparison of telbivudine and entecavir on the change of off- treatment eGFR after 3 years of treatment in non-cirrhotic chronic hepatitis B patients.
 

Author(s): Yang-Sheng Lin, Shou-Chuan Shih, Horng-Yuan Wang, Ching-Chung Lin, Chen-Wang Chang, Ming-Jen Chen

Journal:

 

The change of estimated glomerular filtration rate (eGFR) with off-treatment nucleos(t)ide analogues (NA) in chronic hepatitis B patients (CHB) is unclear. This study is aimed to evaluate the off-treatment eGFR after 3 years of therapy with telbivudine (LdT) or entecavir (ETV) and ...

Last Updated: 31 Jan 2017

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The Prevalence of Occult Hepatitis B Virus in the Hemodialysis Patients in Yazd, Iran.
 

Author(s): Jamshid Ayatollahi, Somayeh Jahanabadi, Mohammad Sharifyazdi, Roya Hemayati, Mahmood Vakili, Seyed Hossein Shahcheraghi

Journal: Acta Med Iran. 2016 Dec;54(12):784-787.

 

Occult HBV infection of hemodialysis (HD) patients is informative in terms of virus transmission. It may be of clinical importance in HD patients. The aim of this study was to investigate the prevalence of anti-HBc in the HD Patients. Number of 126 patients undergoing hemodialysis ...

Last Updated: 25 Jan 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hepatitis B" returned 783 free, full-text review articles on human participants. First 3 results:

Prevalence of chronic hepatitis B virus infection in Thailand: a systematic review and meta-analysis.
 

Author(s): Charline Leroi, Pierrick Adam, Woottichai Khamduang, Suttipong Kawilapat, Nicole Ngo-Giang-Huong, Sumet Ongwandee, Suchada Jiamsiri, Gonzague Jourdain

Journal: Int. J. Infect. Dis.. 2016 Oct;51():36-43.

 

To estimate the number of people living in Thailand with chronic hepatitis B (CHB), a major cause of liver cirrhosis and cancer, in view of the implementation of programs to prevent CHB complications.

Last Updated: 30 Sep 2016

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New Perspectives on Treatment of Hepatitis B Before and After Liver Transplantation.
 

Author(s): Alberto Zanetto, Alberto Ferrarese, Ilaria Bortoluzzi, Patrizia Burra, Francesco Paolo Russo

Journal:

 

The hepatitis B virus (HBV) infects more than 260 million people globally, with increasing incidence, especially in developing countries. Despite antiviral therapies, HBV-related end-stage liver disease remains one of the most important indications for liver transplantation worldwide. ...

Last Updated: 14 Oct 2016

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Hepatitis D virus infection in Slovenian patients with chronic hepatitis B virus infection: a national prevalence study and literature review.
 

Author(s): Mateja M Jelen, Lea Hošnjak, Špela Štunf, Anja Zagožen, Kristina Fujs Komloš, Petra Markočič, Mario Poljak, Katja Seme

Journal: Acta Dermatovenerol Alp Pannonica Adriat. 2016 Sep;25(3):49-53.

 

Of the 350 million individuals chronically infected with hepatitis B virus (HBV) worldwide, approximately 15 to 20 million have been exposed to hepatitis D virus (HDV). This study determined for the first time the HDV prevalence in Slovenian patients with chronic HBV infection. In ...

Last Updated: 3 Oct 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Hepatitis B Research Network Pediatric Cohort Study (HBRN)
 

Status: Recruiting

Condition Summary: Hepatitis B

 

Last Updated: 3 May 2016

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Hepatitis B Research Network Adult Cohort Study
 

Status: Recruiting

Condition Summary: Hepatitis B

 

Last Updated: 3 May 2016

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"Real-life" Cohort of Patients With Chronic Hepatitis B Virus Infection
 

Status: Recruiting

Condition Summary: Hepatitis B

 

Last Updated: 16 Nov 2012

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