Hepatitis D

Common Name(s)

Hepatitis D

Hepatitis D is a viral hepatitis that affects the liver and is caused by the hepatitis D virus, or HDV. HDV can only infect people who have hepatitis B, but it is important to remember that not all people with hepatitis B will know they have the condition because they may not have symptoms. An infection with HDV makes the symptoms of hepatitis B worse and increases liver damage. Symptoms may include sudden fever, extreme tiredness, nausea, lack of appetite, stomach pain, and jaundice (yellowing of the skin). HDV does not always cause symptoms. Most people infected with HDV recover within a month. About 10% of people infected with HDV develop a chronic infection. Chronic HDV infection may cause chronic active hepatitis leading to permanent liver scarring (cirrhosis) and liver failure. HDV is spread through contact with infected blood. Common ways of to become infected with HDV include sharing of infected needles, having sexual contact with a person infected by HDV, and from mother to child during childbirth if the mother is infected with HDV. Hepatitis D is diagnosed through blood tests and possibly a liver biopsy.

A vaccine is available to prevent HBV infection which there also will prevent HDV infection. If the condition becomes chronic, there are treatments available to help slow the damage to the liver but there is no cure at this time. HDV infections are diagnosed through blood tests and possibly liver biopsies. Talk with your doctor if you or a family member has been diagnosed with hepatitis D. Support groups are also good resources of support and information. See also Hepatitis B.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hepatitis D" for support, advocacy or research.

Hepatitis Foundation International

Hepatitis Foundation International is dedicated to promoting wellness and healthy lifestyles for all individuals in order to reduce the incidence of preventable diseases that affect the liver’s health including: obesity, diabetes, fatty liver, high cholesterol, cardiovascular disease, hepatitis, HIV/AIDS, and substance abuse. We inform, educate, and empower by making available reliable and up-to-date information.

Last Updated: 23 Feb 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hepatitis D" for support, advocacy or research.

Hepatitis Foundation International

Hepatitis Foundation International is dedicated to promoting wellness and healthy lifestyles for all individuals in order to reduce the incidence of preventable diseases that affect the liver’s health including: obesity, diabetes, fatty liver, high cholesterol, cardiovascular disease, hepatitis, HIV/AIDS, and substance abuse. We inform, educate, and empower by making available reliable and up-to-date information.

http://www.HepatitisFoundation.org

Last Updated: 23 Feb 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hepatitis D" returned 161 free, full-text research articles on human participants. First 3 results:

Relationships between low serum vitamin D levels and HBV "a" determinant mutations in chronic hepatitis B patients.
 

Author(s): Huijuan Zhu, Xingxiang Liu, Yi Ding, Hui Zhou, Yiying Wang, Zhiwei Zhou, Xinxin Li, Zengli Zhang, Chen Dong

Journal:

 

Vitamin D is significantly associated with virus replication in chronic hepatitis B virus (HBV) infection. However, the relationship between low serum vitamin D levels and HBV "a" determinant mutations remains unknown.

Last Updated: 3 Oct 2016

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Serum 25-hydroxyvitamin D status in pregnant women with chronic hepatitis B virus infection.
 

Author(s): Xue-Ren Gao, Cui-Min Wang, Wen-Jun Wang, Guo-Rong Han, Jian-Qiong Zhang

Journal:

 

Maternal 25-hydroxyvitamin D [25(OH)D] deficiency has a negative influence on the health of the mother and the developing fetus. The aim of this study was to assess serum 25(OH)D status and its relationship to virologic and biochemical parameters in pregnant women with chronic hepatitis ...

Last Updated: 1 Sep 2016

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Vitamin D serum level is associated with Child-Pugh score and metabolic enzyme imbalances, but not viral load in chronic hepatitis B patients.
 

Author(s): Xin-Yan Zhao, Jia Li, Jing-Han Wang, Sohail Habib, Wei Wei, Shu-Jie Sun, Henry W Strobel, Ji-Dong Jia

Journal: Medicine (Baltimore). 2016 Jul;95(27):e3926.

 

Vitamin D deficiency is common in patients with chronic liver diseases. However, vitamin D status in persons with chronic hepatitis B virus (HBV) infection is not consistently reported. Specifically, the impact of liver dysfunction on vitamin D status has not been well addressed.We ...

Last Updated: 12 Jul 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hepatitis D" returned 16 free, full-text review articles on human participants. First 3 results:

Hepatitis D virus infection in Slovenian patients with chronic hepatitis B virus infection: a national prevalence study and literature review.
 

Author(s): Mateja M Jelen, Lea Hošnjak, Špela Štunf, Anja Zagožen, Kristina Fujs Komloš, Petra Markočič, Mario Poljak, Katja Seme

Journal: Acta Dermatovenerol Alp Pannonica Adriat. 2016 Sep;25(3):49-53.

 

Of the 350 million individuals chronically infected with hepatitis B virus (HBV) worldwide, approximately 15 to 20 million have been exposed to hepatitis D virus (HDV). This study determined for the first time the HDV prevalence in Slovenian patients with chronic HBV infection. In ...

Last Updated: 3 Oct 2016

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Hepatitis D virus coinfection and superinfection.
 

Author(s): Francesco Negro

Journal:

 

HDV is a defective RNA pathogen requiring the simultaneous presence of HBV to complete its life cycle. Two major specific patterns of infection have been described: the coinfection with HDV and HBV of a susceptible, anti-HBs-negative individual, or the HDV superinfection of a chronic ...

Last Updated: 4 Nov 2014

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Association between serum vitamin D and severity of liver fibrosis in chronic hepatitis C patients: a systematic meta-analysis.
 

Author(s): Yue-qiu Luo, Xiao-xing Wu, Zong-xin Ling, Yi-wen Cheng, Li Yuan, Charlie Xiang

Journal: J Zhejiang Univ Sci B. 2014 Oct;15(10):900-6.

 

To conduct a systematic review of group studies assessing the association of serum vitamin D status with the severity of liver fibrosis in chronic hepatitis C patients using meta-analysis. The relevant research literatures were identified by searching PubMed and EMBASE databases prior ...

Last Updated: 8 Oct 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Hepatitis Delta International Network
 

Status: Recruiting

Condition Summary: Hepatitis D

 

Last Updated: 26 Aug 2015

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Mother-to-child Hepatitis D Transmission
 

Status: Recruiting

Condition Summary: Hepatitis D; Transmission

 

Last Updated: 21 Nov 2016

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Last Updated: 18 Jan 2017

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