Hepatitis D

Common Name(s)

Hepatitis D

Hepatitis D is a viral hepatitis that affects the liver and is caused by the hepatitis D virus, or HDV. HDV can only infect people who have hepatitis B, but it is important to remember that not all people with hepatitis B will know they have the condition because they may not have symptoms. An infection with HDV makes the symptoms of hepatitis B worse and increases liver damage. Symptoms may include sudden fever, extreme tiredness, nausea, lack of appetite, stomach pain, and jaundice (yellowing of the skin). HDV does not always cause symptoms. Most people infected with HDV recover within a month. About 10% of people infected with HDV develop a chronic infection. Chronic HDV infection may cause chronic active hepatitis leading to permanent liver scarring (cirrhosis) and liver failure. HDV is spread through contact with infected blood. Common ways of to become infected with HDV include sharing of infected needles, having sexual contact with a person infected by HDV, and from mother to child during childbirth if the mother is infected with HDV. Hepatitis D is diagnosed through blood tests and possibly a liver biopsy.

A vaccine is available to prevent HBV infection which there also will prevent HDV infection. If the condition becomes chronic, there are treatments available to help slow the damage to the liver but there is no cure at this time. HDV infections are diagnosed through blood tests and possibly liver biopsies. Talk with your doctor if you or a family member has been diagnosed with hepatitis D. Support groups are also good resources of support and information. See also Hepatitis B.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hepatitis D" for support, advocacy or research.

Hepatitis Foundation International

Hepatitis Foundation International is dedicated to promoting wellness and healthy lifestyles for all individuals in order to reduce the incidence of preventable diseases that affect the liver’s health including: obesity, diabetes, fatty liver, high cholesterol, cardiovascular disease, hepatitis, HIV/AIDS, and substance abuse. We inform, educate, and empower by making available reliable and up-to-date information.

Last Updated: 23 Feb 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hepatitis D" for support, advocacy or research.

Hepatitis Foundation International

Hepatitis Foundation International is dedicated to promoting wellness and healthy lifestyles for all individuals in order to reduce the incidence of preventable diseases that affect the liver’s health including: obesity, diabetes, fatty liver, high cholesterol, cardiovascular disease, hepatitis, HIV/AIDS, and substance abuse. We inform, educate, and empower by making available reliable and up-to-date information.

http://www.HepatitisFoundation.org

Last Updated: 23 Feb 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hepatitis D" returned 173 free, full-text research articles on human participants. First 3 results:

Whole-gene analysis of two groups of hepatitis B virus C/D inter-genotype recombinant strains isolated in Tibet, China.
 

Author(s): Tiezhu Liu, Fuzhen Wang, Shuang Zhang, Feng Wang, Qingling Meng, Guomin Zhang, Fuqiang Cui, Dorji Dunzhu, Wenjiao Yin, Shengli Bi, Liping Shen

Journal:

 

Tibet is a highly hepatitis B virus (HBV) endemic area. Two types of C/D recombinant HBV are commonly isolated in Tibet and have been previously described. In an effort to better understand the molecular characteristic of these C/D recombinant strains from Tibet, we undertook a multistage ...

Last Updated: 27 Jun 2017

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Correction of vitamin D deficiency facilitated suppression of IP-10 and DPP IV levels in patients with chronic hepatitis C: A randomised double-blinded, placebo-control trial.
 

Author(s): Piyawat Komolmit, Kriangsak Charoensuk, Kessarin Thanapirom, Sirinporn Suksawatamnuay, Panarat Thaimai, Chintana Chirathaworn, Yong Poovorawan

Journal:

 

Vitamin D deficiency was common among patients with chronic hepatitis C (CHC) and had negative influence on treatment outcome. Correction of vitamin D deficiency improved treatment response. Interferon gamma-induced protein 10 (IP-10) and enzyme dipeptidyl peptidase-4 (DPP IV) involved ...

Last Updated: 4 Apr 2017

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Genetic variation in the vitamin D pathway CYP2R1 gene predicts sustained HBeAg seroconversion in chronic hepatitis B patients treated with pegylated interferon: A multicenter study.
 

Author(s): Kessarin Thanapirom, Sirinporn Suksawatamnuay, Wattana Sukeepaisarnjareon, Tawesak Tanwandee, Phunchai Charatcharoenwitthaya, Satawat Thongsawat, Apinya Leerapun, Teerha Piratvisuth, Rattana Boonsirichan, Chalermrat Bunchorntavakul, Chaowalit Pattanasirigool, Bubpha Pornthisarn, Supot Tantipanichtheerakul, Ekawee Sripariwuth, Woramon Jeamsripong, Teeranan Sanpajit, Yong Poovorawan, Piyawat Komolmit

Journal:

 

Evidence of a role of vitamin D in the immune system is increasing. Low serum vitamin D is associated with increased hepatitis B virus replication. Genome-wide association study (GWAS) data has revealed a number of the single nucleotide polymorphisms (SNPs) within the vitamin D synthetic ...

Last Updated: 15 Mar 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hepatitis D" returned 18 free, full-text review articles on human participants. First 3 results:

Hepatitis D virus infection in Slovenian patients with chronic hepatitis B virus infection: a national prevalence study and literature review.
 

Author(s): Mateja M Jelen, Lea Hošnjak, Špela Štunf, Anja Zagožen, Kristina Fujs Komloš, Petra Markočič, Mario Poljak, Katja Seme

Journal: Acta Dermatovenerol Alp Pannonica Adriat. 2016 Sep;25(3):49-53.

 

Of the 350 million individuals chronically infected with hepatitis B virus (HBV) worldwide, approximately 15 to 20 million have been exposed to hepatitis D virus (HDV). This study determined for the first time the HDV prevalence in Slovenian patients with chronic HBV infection. In ...

Last Updated: 3 Oct 2016

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Hepatitis B Virus and Hepatitis D Virus Entry, Species Specificity, and Tissue Tropism.
 

Author(s): Koichi Watashi, Takaji Wakita

Journal:

 

Entry of hepatitis B (HBV) and hepatitis D viruses (HDV) into a host cell represents the initial step of infection. This process requires multiple steps, including the low-affinity attachment of the virus to the cell surface, followed by high-affinity attachment to specific receptor(s), ...

Last Updated: 4 Aug 2015

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Hepatitis D Virus: Introduction and Epidemiology.
 

Author(s): Mario Rizzetto

Journal:

 

Hepatitis D is caused by the hepatitis D virus (HDV), a unique RNA pathogen that requires the hepatitis B surface antigen (HBsAg) to infect. Hepatitis D is transmitted by the parenteral route. The main susceptible group is patients with chronic HBsAg infection who become superinfected ...

Last Updated: 3 Jul 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Ezetimibe for Patients With Chronic Hepatitis D
 

Status: Recruiting

Condition Summary: Chronic Hepatitis D

 

Last Updated: 28 Mar 2017

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The Hepatitis Delta International Network
 

Status: Recruiting

Condition Summary: Hepatitis D

 

Last Updated: 25 Aug 2017

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A Study of Lonafarnib With or Without Ritonavir in Patients With HDV
 

Status: Not yet recruiting

Condition Summary: Chronic Delta Hepatitis

 

Last Updated: 16 Nov 2016

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