Hereditary angioedema

Common Name(s)

Hereditary angioedema, HAE

Hereditary angioedema (HAE) is a rare, debilitating, and potentially fatal genetic disorder that is characterized by episodes of swelling in various body parts including the hands, feet, face and airway. In addition, patients often have bouts of excruciating abdominal pain, nausea, and vomiting that is caused by swelling in the intestinal wall. Airway swelling is particularly dangerous and can lead to death by asphyxiation.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary angioedema" for support, advocacy or research.

Logo
US Hereditary Angioedema Association

Helping HAE patients and their families to achieve lifelong health.

Last Updated: 5 Mar 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary angioedema" for support, advocacy or research.

Logo
US Hereditary Angioedema Association

Helping HAE patients and their families to achieve lifelong health.

http://www.haea.org

Last Updated: 5 Mar 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

General Resources

HAE Essentials - A Patient's Guide

Video series of HAE disease information for patients and family and caregivers

Updated 20 Nov 2012

Go To URL
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hereditary angioedema" returned 185 free, full-text research articles on human participants. First 3 results:

Improving the Management of Hereditary Angioedema.
 

Author(s): Pedro Giavina-Bianchi, Jorge Kalil

Journal:

 

Last Updated: 31 Dec 1969

Go To URL
Brazilian Guidelines for Hereditary Angioedema Management - 2017 Update Part 1: Definition, Classification and Diagnosis.
 

Author(s): Pedro Giavina-Bianchi, Luisa Karla Arruda, Marcelo V Aun, Regis A Campos, Herberto J Chong-Neto, Rosemeire N Constantino-Silva, Fátima R Fernandes, Maria F Ferraro, Mariana P L Ferriani, Alfeu T França, Gustavo Fusaro, Juliana F B Garcia, Shirley Komninakis, Luana S M Maia, Eli Mansour, Adriana S Moreno, Antonio A Motta, João B Pesquero, Nathalia Portilho, Nelson A Rosário, Faradiba S Serpa, Dirceu Solé, Priscila Takejima, Eliana Toledo, Solange O.R Valle, Camila L Veronez, Anete S Grumach

Journal: Clinics (Sao Paulo). 2018 ;73():e310.

 

Hereditary angioedema is an autosomal dominant disease characterized by recurrent angioedema attacks with the involvement of multiple organs. The disease is unknown to many health professionals and is therefore underdiagnosed. Patients who are not adequately diagnosed and treated ...

Last Updated: 31 Dec 1969

Go To URL
Usefulness of C1 esterase inhibitor protein concentrate in the management of hereditary angioedema of oropharyngeal tissue.
 

Author(s): M Yigit, O Sogut, H Lisar, E Yigit

Journal: Niger J Clin Pract. 2018 Apr;21(4):531-533.

 

Hereditary angioedema is an autosomal-dominant disorder caused by mutation of the gene encoding the C1 esterase inhibitor (C1-INH). It manifests as painless, nonpruritic, nonpitting episodic swelling of the subcutaneous tissues, gastrointestinal, and upper respiratory tracts in the ...

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hereditary angioedema" returned 28 free, full-text review articles on human participants. First 3 results:

New Treatments for Hereditary Angioedema.
 

Author(s): Nathan M Johnson, Mariana A Phillips

Journal: Skin Therapy Lett.. 2018 01;23(1):6-8.

 

Hereditary angioedema is characterized by severe, episodic edema of the subcutaneous and mucosal tissue. The disease carries significant morbidity and mortality due to involvement of the gastrointestinal tract and upper airway. Recent advances in the treatment of hereditary angioedema ...

Last Updated: 31 Dec 1969

Go To URL
Emerging Therapies in Hereditary Angioedema.
 

Author(s): Meng Chen, Marc A Riedl

Journal: Immunol Allergy Clin North Am. 2017 08;37(3):585-595.

 

Remarkable progress has been made in the treatment of bradykinin-mediated angioedema with the advent of multiple new therapies. Patients now have effective medications available for prophylaxis and treatment of acute attacks. However, hereditary angioedema is a burdensome disease ...

Last Updated: 31 Dec 1969

Go To URL
Management of Children With Hereditary Angioedema Due to C1 Inhibitor Deficiency.
 

Author(s): Michael M Frank, Bruce Zuraw, Aleena Banerji, Jonathan A Bernstein, Timothy Craig, Paula Busse, Sandra Christiansen, Marc Davis-Lorton, H Henry Li, William R Lumry, Marc Riedl,

Journal: Pediatrics. 2016 11;138(5):.

 

Hereditary angioedema (HAE) is a potentially life-threatening inherited disease characterized by attacks of skin swelling, severe abdominal pain, and upper airway swelling. Attacks typically begin in childhood, but the appropriate diagnosis is often missed. Attacks do not respond ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study to Investigate CSL312 in Subjects With Hereditary Angioedema (HAE)
 

Status: Not yet recruiting

Condition Summary: Hereditary Angioedema

 

Last Updated: 17 Oct 2018

Go to URL
Study of BCX7353 as a Treatment for Attacks of Hereditary Angioedema
 

Status: Recruiting

Condition Summary: Hereditary Angioedema (HAE)

 

Last Updated: 7 Jun 2018

Go to URL
Study to Assess the Tolerability and Safety of Ecallantide in Children and Adolescents With Hereditary Angioedema
 

Status: Recruiting

Condition Summary: Hereditary Angioedema Types I and II

 

Last Updated: 3 Jan 2017

Go to URL