Hereditary angioedema

Common Name(s)

Hereditary angioedema, HAE

Hereditary angioedema (HAE) is a rare, debilitating, and potentially fatal genetic disorder that is characterized by episodes of swelling in various body parts including the hands, feet, face and airway. In addition, patients often have bouts of excruciating abdominal pain, nausea, and vomiting that is caused by swelling in the intestinal wall. Airway swelling is particularly dangerous and can lead to death by asphyxiation.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary angioedema" for support, advocacy or research.

Logo
US Hereditary Angioedema Association

Helping HAE patients and their families to achieve lifelong health.

Last Updated: 5 Mar 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary angioedema" for support, advocacy or research.

Logo
US Hereditary Angioedema Association

Helping HAE patients and their families to achieve lifelong health.

http://www.haea.org

Last Updated: 5 Mar 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

General Resources

HAE Essentials - A Patient's Guide

Video series of HAE disease information for patients and family and caregivers

Updated 20 Nov 2012

Go To URL
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hereditary angioedema" returned 181 free, full-text research articles on human participants. First 3 results:

Outcomes of long term treatments of type I hereditary angioedema in a Turkish family.
 

Author(s): Gulsen Akoglu, Belgin Kesim, Gokhan Yildiz, Ahmet Metin

Journal: An Bras Dermatol. ;92(5):655-660.

 

Hereditary angioedema is a rare autosomal dominantly inherited immunodeficiency disorder characterized by potentially life-threatening angioedema attacks.

Last Updated: 31 Dec 1969

Go To URL
Hereditary angioedema: Assessing the hypothesis for underlying autonomic dysfunction.
 

Author(s): Maddalena A Wu, Francesco Casella, Francesca Perego, Chiara Suffritti, Nada Afifi Afifi, Eleonora Tobaldini, Andrea Zanichelli, Chiara Cogliati, Nicola Montano, Marco Cicardi

Journal:

 

Attacks of Hereditary Angioedema due to C1-inhibitor deficiency (C1-INH-HAE)are often triggered by stressful events/hormonal changes.

Last Updated: 31 Dec 1969

Go To URL
Comparison of the Frequency of Angioedema Attack, before and during Pregnancy, in a Patient with Type I Hereditary Angioedema.
 

Author(s): Atsushi Satomura, Takayuki Fujita, Tomohiro Nakayama

Journal: Intern. Med.. 2018 Mar;57(5):751-755.

 

The patient was a 38-year-old Japanese woman who had been diagnosed with hereditary angioedema type I at 7 years of age based on her family history. She had undergone four pregnancies. She gave birth to a healthy baby girl after her first pregnancy and had reported few episodes of ...

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hereditary angioedema" returned 27 free, full-text review articles on human participants. First 3 results:

New Treatments for Hereditary Angioedema.
 

Author(s): Nathan M Johnson, Mariana A Phillips

Journal: Skin Therapy Lett.. 2018 01;23(1):6-8.

 

Hereditary angioedema is characterized by severe, episodic edema of the subcutaneous and mucosal tissue. The disease carries significant morbidity and mortality due to involvement of the gastrointestinal tract and upper airway. Recent advances in the treatment of hereditary angioedema ...

Last Updated: 31 Dec 1969

Go To URL
Emerging Therapies in Hereditary Angioedema.
 

Author(s): Meng Chen, Marc A Riedl

Journal: Immunol Allergy Clin North Am. 2017 08;37(3):585-595.

 

Remarkable progress has been made in the treatment of bradykinin-mediated angioedema with the advent of multiple new therapies. Patients now have effective medications available for prophylaxis and treatment of acute attacks. However, hereditary angioedema is a burdensome disease ...

Last Updated: 31 Dec 1969

Go To URL
Management of Children With Hereditary Angioedema Due to C1 Inhibitor Deficiency.
 

Author(s): Michael M Frank, Bruce Zuraw, Aleena Banerji, Jonathan A Bernstein, Timothy Craig, Paula Busse, Sandra Christiansen, Marc Davis-Lorton, H Henry Li, William R Lumry, Marc Riedl,

Journal: Pediatrics. 2016 Nov;138(5):.

 

Hereditary angioedema (HAE) is a potentially life-threatening inherited disease characterized by attacks of skin swelling, severe abdominal pain, and upper airway swelling. Attacks typically begin in childhood, but the appropriate diagnosis is often missed. Attacks do not respond ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of BCX7353 as a Treatment for Attacks of Hereditary Angioedema
 

Status: Recruiting

Condition Summary: Hereditary Angioedema (HAE)

 

Last Updated: 7 Jun 2018

Go to URL
Study to Assess the Tolerability and Safety of Ecallantide in Children and Adolescents With Hereditary Angioedema
 

Status: Recruiting

Condition Summary: Hereditary Angioedema Types I and II

 

Last Updated: 3 Jan 2017

Go to URL
A Long Term Safety Study of BCX7353 in Hereditary Angioedema
 

Status: Recruiting

Condition Summary: Hereditary Angioedema; HAE; Prophylaxis

 

Last Updated: 6 Aug 2018

Go to URL