Hereditary cancer

Common Name(s)

Hereditary cancer, Cancer predisposition, Cancer, Hereditary

Hereditary cancer, or inherited cancer, is cancer that occurs as a result of a genetic change (mutation) that a person is born with. All cancer is a result of genetic changes that cause a cell to divide faster than it should. These changes can occur in a gene that slows down cell division, in a gene that speeds up cell division, or in a gene that is in charge of repairing genetic changes. These are collectively known as cancer susceptibility genes. People have two copies of these genes in all of their cells.

As a person ages and gets exposed to different things in the environment, such as smoking or the sun, their genes are changed (acquired mutations). Most cancer occurs because both copies of a person’s cancer susceptibility gene get changed over time (sporadic cancer). In hereditary cancer, a person is born with a change in one copy of a cancer susceptibility gene. This significantly increases their lifetime risk of cancer because it is more likely, and takes less time, to get a change in the one remaining unchanged gene copy.

About 10% of all cancer is hereditary and there are many types, depending on the gene that is affected. The most common forms of hereditary cancer are breast cancer, ovarian cancer, and colorectal cancer. Factors that increase the risk of cancer being hereditary include multiple family members affected with similar types of cancer, cancer at a young age (less than 50 years) in the family, rare forms of cancer in the family (such as kidney cancer or breast cancer in a man), and more than one type of primary cancer in a person (a woman with both breast and ovarian cancer). If you have signs of hereditary cancer in your family, talk with a genetic counselor about the likelihood of it being hereditary as well as genetic testing options. Diagnosing hereditary cancer in a family can help to determine a person’s cancer risk as well as determine cancer surveillance recommendations.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary cancer" for support, advocacy or research.

Logo
Canadian Multiple Endocrine Neoplasia Society, Inc.

We help people with MEN by referring them to Drs and genetist. We also offer emotional support and literature We can be contacted anytime via email. We do try to find a member close to the newly diagnosed MEN Patient to let them know that "They Are Not Alone"

Last Updated: 31 Jan 2013

View Details
Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

Last Updated: 26 Dec 2012

View Details
Colon Cancer Alliance for Research & Education for Lynch Syndrome

CCARE Lynch Syndrome is the national non-profit devoted to saving lives and leading the fight against Lynch syndrome through education, advocacy and research.

Last Updated: 5 Aug 2013

View Details
FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

Last Updated: 5 May 2014

View Details
Logo
Lynch Syndrome International

To provide support for those at high risk to hereditary Lynch syndrome cancers, public awareness of Lynch syndrome, education for medical offices and support for research endeavors.

Last Updated: 16 Jun 2015

View Details
Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

Last Updated: 6 Nov 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary cancer" for support, advocacy or research.

Logo
Canadian Multiple Endocrine Neoplasia Society, Inc.

We help people with MEN by referring them to Drs and genetist. We also offer emotional support and literature We can be contacted anytime via email. We do try to find a member close to the newly diagnosed MEN Patient to let them know that "They Are Not Alone"

http://mensociety.ca/

Last Updated: 31 Jan 2013

View Details
Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

View Details
Colon Cancer Alliance for Research & Education for Lynch Syndrome

CCARE Lynch Syndrome is the national non-profit devoted to saving lives and leading the fight against Lynch syndrome through education, advocacy and research.

http://fightlynch.org/

Last Updated: 5 Aug 2013

View Details
FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

http://www.facingourrisk.org

Last Updated: 5 May 2014

View Details
Logo
Lynch Syndrome International

To provide support for those at high risk to hereditary Lynch syndrome cancers, public awareness of Lynch syndrome, education for medical offices and support for research endeavors.

http://www.lynchcancers.com

Last Updated: 16 Jun 2015

View Details
Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

http://stupidcancer.org

Last Updated: 6 Nov 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hereditary cancer" returned 615 free, full-text research articles on human participants. First 3 results:

Hereditary leiomyomatosis and renal cell cancer syndrome associated renal cell carcinoma.
 

Author(s): Shraddha Adamane, Sangeeta Desai, Santosh Menon

Journal: Indian J Pathol Microbiol. ;60(1):108-110.

 

Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is a recently described entity with unknown exact prevalence. The affected individuals are predisposed to have multiple leiomyomas and renal cancer due to germline mutation in fumarate hydratase gene on chromosome 1. The knowledge ...

Last Updated: 14 Feb 2017

Go To URL
Risk-Reducing Surgery in Hereditary Breast and Ovarian Cancer.
 

Author(s): Lynn C Hartmann, Noralane M Lindor

Journal: N. Engl. J. Med.. 2016 Jun;374(24):2404.

 

Last Updated: 16 Jun 2016

Go To URL
BRCA1 Gene Mutation Screening for the Hereditary Breast and/or Ovarian Cancer Syndrome in Breast Cancer Cases: a First High Resolution DNA Melting Analysis in Indonesia.
 

Author(s): Farmaditya Ep Mundhofir, Catharina Endah Wulandari, Yan Wisnu Prajoko, Tri Indah Winarni

Journal: Asian Pac. J. Cancer Prev.. 2016 ;17(3):1539-46.

 

Specific patterns of the hereditary breast and ovarian cancer (HBOC) syndrome are related to mutations in the BRCA1 gene. One hundred unrelated breast cancer patients were interviewed to obtain clinical symptoms and signs, pedigree and familial history of HBOC syndrome related cancer. ...

Last Updated: 4 Apr 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hereditary cancer" returned 115 free, full-text review articles on human participants. First 3 results:

Hereditary melanoma: Update on syndromes and management: Emerging melanoma cancer complexes and genetic counseling.
 

Author(s): Efthymia Soura, Philip J Eliades, Kristen Shannon, Alexander J Stratigos, Hensin Tsao

Journal: J. Am. Acad. Dermatol.. 2016 Mar;74(3):411-20; quiz 421-2.

 

Recent advances in cancer genomics have enabled the discovery of many cancer-predisposing genes that are being used to classify new familial melanoma/cancer syndromes. In addition to CDKN2A and CDK4, germline variants in TERT, MITF, and BAP1 have been added to the list of genes harboring ...

Last Updated: 19 Feb 2016

Go To URL
Genetic testing for hereditary cancer predisposition: BRCA1/2, Lynch syndrome, and beyond.
 

Author(s): M J Hall, E I Obeid, S C Schwartz, G Mantia-Smaldone, A D Forman, M B Daly

Journal: Gynecol. Oncol.. 2016 Mar;140(3):565-74.

 

Obstetrician/gynecologists and gynecologic oncologists serve an integral role in the care of women at increased hereditary risk of cancer. Their contribution includes initial identification of high risk patients, screening procedures like bimanual exam, trans-vaginal ultrasound and ...

Last Updated: 24 Feb 2016

Go To URL
Pancreaticoduodenectomy for locally advanced colon cancer in hereditary nonpolyposis colorectal cancer.
 

Author(s): Rebecca Zhu, Gabriella Grisotti, Ronald R Salem, Sajid A Khan

Journal:

 

Hereditary nonpolyposis colorectal cancer (HNPCC), or Lynch syndrome, accounts for 3% of newly diagnosed cases of colorectal cancer. While a partial or subtotal colectomy is indicated for early stage disease, there is a paucity of data addressing locally advanced disease involving the foregut.

Last Updated: 15 Jan 2016

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 10 Mar 2017

Go to URL
Combined Breast Cancer Risk Study
 

Status: Recruiting

Condition Summary: Hereditary Cancer

 

Last Updated: 6 Mar 2017

Go to URL
Cancer Genetics Hereditary Cancer Panel Testing
 

Status: Recruiting

Condition Summary: Hereditary Breast and Ovarian Cancer

 

Last Updated: 31 Jan 2016

Go to URL