Hereditary gingival fibromatosis

Common Name(s)

Hereditary gingival fibromatosis

Gingival fibromatosis is a rare overgrowth condition characterized by a benign, slowly progressive, nonhemorrhagic, fibrous enlargement of maxillary and mandibular keratinized gingiva (summary by {7:Hart et al., 2002}). Genetic Heterogeneity of Hereditary Gingival Fibromatosis Other loci for gingival fibromatosis have been mapped to chromosome 5q (GINGF2; {605544}), chromosome 2p23.3-p22.3 (GINGF3; {609955}), and chromosome 11p15 (GINGF4; {611010}). GINGF5 ({617626}) is caused by mutation in the REST gene ({600571}) on chromosome 4q12. There is some evidence for a locus on chromosome 2p16-p13 (see MAPPING).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary gingival fibromatosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary gingival fibromatosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hereditary gingival fibromatosis" returned 15 free, full-text research articles on human participants. First 3 results:

REST Final-Exon-Truncating Mutations Cause Hereditary Gingival Fibromatosis.
 

Author(s): Yavuz Bayram, Janson J White, Nursel Elcioglu, Megan T Cho, Neda Zadeh, Asuman Gedikbasi, Sukru Palanduz, Sukru Ozturk, Kivanc Cefle, Ozgur Kasapcopur, Zeynep Coban Akdemir, Davut Pehlivan, Amber Begtrup, Claudia M B Carvalho, Ingrid Sophie Paine, Ali Mentes, Kivanc Bektas-Kayhan, Ender Karaca, Shalini N Jhangiani, Donna M Muzny, , Richard A Gibbs, James R Lupski

Journal: Am. J. Hum. Genet.. 2017 Jul;101(1):149-156.

 

Hereditary gingival fibromatosis (HGF) is the most common genetic form of gingival fibromatosis that develops as a slowly progressive, benign, localized or generalized enlargement of keratinized gingiva. HGF is a genetically heterogeneous disorder and can be transmitted either as ...

Last Updated: 31 Dec 1969

Go To URL
Analysis of mutations in the SOS-1 gene in two Polish families with hereditary gingival fibromatosis.
 

Author(s): K Gawron, G Bereta, Z Nowakowska, K Łazarz-Bartyzel, J Potempa, M Chomyszyn-Gajewska, R Górska, P Plakwicz

Journal: Oral Dis. 2017 Oct;23(7):983-989.

 

To establish whether two families from Malopolska and Mazovia provinces in Poland are affected by hereditary gingival fibromatosis type 1, caused by a single-cytosine insertion in exon 21 of the Son-of-Sevenless-1 gene.

Last Updated: 31 Dec 1969

Go To URL
Hereditary gingival fibromatosis: clinical and ultrastructural features of a new family.
 

Author(s): Sabina-Pena-Borges Pego, Ricardo D Coletta, Danilo-Cangussu Mendes, Paulo-Rogério de Faria, Mário R Melo-Filho, Lucas-Rodrigues Alves, Hercílio Martelli-Júnior

Journal:

 

This article describes the diagnosis, clinical and microscopic (histopathology and ultrastructural) features and treatment of a new family with hereditary gingival fibromatosis (HGF) and highlights the importance of this genetic condition.

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hereditary gingival fibromatosis" returned 0 free, full-text review articles on human participants.

 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.