Insensitivity to pain, congenital, with anhidrosis

Common Name(s)

Insensitivity to pain, congenital, with anhidrosis, Hereditary insensitivity to pain with anhidrosis

Congenital insensitivity to pain with anhidrosis (CIPA) is an inherited condition characterized by the inability to feel pain and temperature and decreased or absent sweating (anhidrosis). The signs and symptoms of CIPA usually appear at birth or during infancy. People with CIPA may also heal slowly from skin and bone injuries, which can lead to chronic bone infections (osteomyelitis) or a condition called Charcot joints, where the bones and tissue surrounding joints are destroyed. Absent sweating can cause recurrent, extremely high fevers (hyperpyrexia) and seizures brought on by high temperature (febrile seizures). CIPA is caused by mutations in the NTRK1 gene and is inherited in an autosomal recessive pattern.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Insensitivity to pain, congenital, with anhidrosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
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The terms "Insensitivity to pain, congenital, with anhidrosis" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.