Hereditary multiple osteochondromas

Common Name(s)

Hereditary multiple osteochondromas

Hereditary multiple osteochondromas (HMO) (formerly called hereditary multiple exostoses) is a genetic condition in which people develop multiple benign (noncancerous) bone tumors that are covered by cartilage (called osteochondromas). The number and location of osteochondromas varies greatly among affected individuals. These tumors are not present at birth, but almost all affected people develop multiple osteochondromas by the time they are 12 years old. Once the bones stop growing, the development of new osteochondromas also usually stops. Osteochondromas can cause abnormal growth of the arms, hands, and legs, which can lead to uneven limb lengths (limb length discrepancy) and short stature. These tumors may cause pain, limit joint movement, and exert pressure on nerves, blood vessels, and surrounding tissues. Osteochondromas are typically benign; however, researchers estimate that people with HMO have about a 1% lifetime risk of these tumors becoming a cancerous osteochondrosarcoma. HMO is caused by mutations in the EXT1 and EXT2 genes and is inherited in an autosomal dominant pattern.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary multiple osteochondromas" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hereditary multiple osteochondromas" returned 3 free, full-text research articles on human participants. First 3 results:

Genetic screening of EXT1 and EXT2 in Cypriot families with hereditary multiple osteochondromas.
 

Author(s): George A Tanteles, Michael Nicolaou, Vassos Neocleous, Christos Shammas, Maria A Loizidou, Angelos Alexandrou, Elena Ellina, Nasia Patsia, Carolina Sismani, Leonidas A Phylactou, Violetta Christophidou-Anastasiadou

Journal: J. Genet.. 2015 Dec;94(4):749-54.

 

Last Updated: 22 Dec 2015

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[Molecular diagnosis and prenatal diagnosis in a hereditary multiple osteochondromas family].
 

Author(s): Ying Tang, De-zhu Zheng, Xiao-yan Guo, Juan Liao, Feng-hua Lan

Journal: Beijing Da Xue Xue Bao. 2013 Dec;45(6):906-9.

 

To identify the mutation in the disease gene and provide prenatal diagnosis for a hereditary multiple osteochondromas (HMO) family.

Last Updated: 17 Dec 2013

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Treatment of multiple hereditary osteochondromas of the forearm in children: a study of surgical procedures.
 

Author(s): E K Shin, N F Jones, J F Lawrence

Journal: J Bone Joint Surg Br. 2006 Feb;88(2):255-60.

 

We have evaluated the clinical outcomes of simple excision, ulnar lengthening and the Sauvé-Kapandji procedure in the treatment of deformities of the forearm in patients with multiple hereditary osteochondromas. The medical records of 29 patients (33 forearms) were reviewed; 22 patients ...

Last Updated: 25 Jan 2006

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Reviews from the PubMed Database

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The terms "Hereditary multiple osteochondromas" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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