High cholesterol

Common Name(s)

High cholesterol, Hypercholesterolemia

High cholesterol, or hypercholesterolemia, is a condition in which there are high levels of cholesterol in the blood. Cholesterol is a thick, fat-like substance made by our body, mainly in the liver. We also get cholesterol from some of the foods we eat, such as egg yolks, meat, poultry, fish, and dairy products. Our bodies needs cholesterol, but too much may cause health problems. Too much cholesterol may stick to the sides of arteries (the blood vessels which carry oxygen rich blood to every part of our body). As more cholesterol builds up, a mass of cholesterol and other substances that circulate in our blood form plaques or clumps on the wall of the artery. As the plaque builds, the arteries become narrow and stiff (also known as atherosclerosis). Decreased flow of oxygen to the heart may cause angina (chest pain) or a heart attack. Decreased oxygen flow to the legs may cause leg pain or peripheral artery disease. Sometimes a plaque ruptures, and the blood clot that forms to stop the bleeding blocks the artery completely leading to a heart attack or stroke, depending on the artery affected.

There are often no symptoms in the early stages of high cholesterol. The best way to find out if you have high cholesterol is to have a lipid panel/lipid profile blood test. Risk factors associated with high cholesterol include: family history of high cholesterol or heart disease, smoking, diabetes, high blood pressure, obesity, poor diet, and lack of exercise. Certain types of high cholesterol may run in families. Treatment to lower cholesterol levels may include exercise, eating food low in cholesterol, and medication. Sometimes surgery may be needed. Early diagnosis and treatment have been shown to improve the health of individuals affected by high cholesterol. Talk with your doctor about the latest treatments to decide which options are the best for you.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "High cholesterol" for support, advocacy or research.

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Familial Hypercholesterolemia (FH) Foundation

The FH Foundation is a patient-centered nonprofit organization dedicated to education, advocacy, and research of Familial Hypercholesterolemia (FH). Our mission is to raise awareness and save lives by increasing the rate of early diagnosis and encouraging proactive treatment. If left untreated, FH leads to aggressive and premature heart disease in women, men and children of all racial and ethnic backgrounds.

Last Updated: 1 Jun 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "High cholesterol" for support, advocacy or research.

Logo
Familial Hypercholesterolemia (FH) Foundation

The FH Foundation is a patient-centered nonprofit organization dedicated to education, advocacy, and research of Familial Hypercholesterolemia (FH). Our mission is to raise awareness and save lives by increasing the rate of early diagnosis and encouraging proactive treatment. If left untreated, FH leads to aggressive and premature heart disease in women, men and children of all racial and ethnic backgrounds.

http://www.thefhfoundation.org

Last Updated: 1 Jun 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "High cholesterol" returned 1025 free, full-text research articles on human participants. First 3 results:

High-Sensitivity C-Reactive Protein Combined with Low-Density Lipoprotein Cholesterol as the Targets of Statin Therapy in Patients with Acute Coronary Syndrome.
 

Author(s): Ming Fang, Qiaohui Qian, Zhihong Zhao, Luoning Zhu, Jinwen Su, Xinming Li

Journal: Int Heart J. 2018 Mar;59(2):300-306.

 

To investigate the combination of high-sensitivity C-reactive protein (hs-CRP) and Low-density lipoprotein (LDL)-C as the targets for statin treatment in patients with acute coronary syndrome (ACS). This single-center, prospective, randomized study was performed in 400 patients treated ...

Last Updated: 31 Dec 1969

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Low serum levels of High-Density Lipoprotein cholesterol (HDL-c) as an indicator for the development of severe postpartum depressive symptoms.
 

Author(s): Raji Ramachandran Pillai, Anand Babu Wilson, Nancy R Premkumar, Shivanand Kattimani, Haritha Sagili, Soundravally Rajendiran

Journal:

 

Postpartum depression (PPD) is a psychiatric complication of childbirth affecting 10-20% of new mothers and has negative impact on both mother and infant. Serum lipid levels have been related to depressive disorders, but very limited literatures are available regarding the lipid levels ...

Last Updated: 31 Dec 1969

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Interaction between TCF7L2 polymorphism and dietary fat intake on high density lipoprotein cholesterol.
 

Author(s): Dhanasekaran Bodhini, Szilvia Gaal, Israa Shatwan, Kandaswamy Ramya, Basma Ellahi, Shelini Surendran, Vasudevan Sudha, Mohan R Anjana, Viswanathan Mohan, Julie A Lovegrove, Venkatesan Radha, Karani Santhanakrishnan Vimaleswaran

Journal:

 

Recent evidence suggests that lifestyle factors influence the association between the Melanocortin 4 receptor (MC4R) and Transcription Factor 7-Like 2 (TCF7L2) gene variants and cardio-metabolic traits in several populations; however, the available research is limited among the Asian ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "High cholesterol" returned 58 free, full-text review articles on human participants. First 3 results:

Impact of high cholesterol and endoplasmic reticulum stress on metabolic diseases: An updated mini-review.
 

Author(s): Erdi Sozen, Nesrin Kartal Ozer

Journal: Redox Biol. 2017 08;12():456-461.

 

Endoplasmic reticulum (ER) is the major site of protein folding and calcium storage. Beside the role of ER in protein homeostasis, it controls the cholesterol production and lipid-membrane biosynthesis as well as surviving and cell death signaling mechanisms in the cell. It is well-documented ...

Last Updated: 31 Dec 1969

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Cholesterol efflux capacity of high-density lipoprotein correlates with survival and allograft vasculopathy in cardiac transplant recipients.
 

Author(s): Ali Javaheri, Maria Molina, Payman Zamani, Amrith Rodrigues, Eric Novak, Susan Chambers, Patricia Stutman, Wilhelmina Maslanek, Mary Williams, Scott M Lilly, Peter Heeger, Mohamed H Sayegh, Anil Chandraker, David M Briscoe, Kevin P Daly, Randall Starling, David Ikle, Jason Christie, J Eduardo Rame, Lee R Goldberg, Jeffrey Billheimer, Daniel J Rader

Journal: J. Heart Lung Transplant.. 2016 Nov;35(11):1295-1302.

 

Cardiac allograft vasculopathy (CAV) is a major cause of mortality after cardiac transplantation. High-density lipoprotein (HDL) cholesterol efflux capacity (CEC) is inversely associated with coronary artery disease. In 2 independent studies, we tested the hypothesis that reduced ...

Last Updated: 31 Dec 1969

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MicroRNAs and High-Density Lipoprotein Cholesterol Metabolism.
 

Author(s): Koh Ono, Takahiro Horie, Tomohiro Nishino, Osamu Baba, Yasuhide Kuwabara, Takeshi Kimura

Journal: Int Heart J. 2015 ;56(4):365-71.

 

MicroRNAs (miRNAs) are small non-protein-coding RNAs that negatively regulate gene expression. They bind to the 3'-untranslated region of specific mRNAs and inhibit translation or promote mRNA degradation. Dyslipidemia/hyperlipidemia is a well-accepted risk factor for the development ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Awareness and Detection of Familial Hypercholesterolemia
 

Status: Recruiting

Condition Summary: Hypercholesterolemia

 

Last Updated: 1 Aug 2017

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Effect of Indian Gooseberry Extract (AMX160) in Hypercholesterolemia
 

Status: Not yet recruiting

Condition Summary: Hypercholesterolemia

 

Last Updated: 4 May 2018

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A Multiple Ascending Dose Study of HTD1801 in Adults With Hypercholesterolemia
 

Status: Recruiting

Condition Summary: Hypercholesterolemia

 

Last Updated: 12 Jun 2018

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