Flaujeac Factor Deficiency

Common Name(s)

Flaujeac Factor Deficiency, High molecular weight kininogen deficiency

High molecular weight kininogen (HMWK) deficiency is an autosomal recessive coagulation defect. It is known by a variety of names, including Fitzgerald trait, Flaujeac trait, and Williams trait. Patients with HWMK deficiency do not have a hemorrhagic tendency, but they exhibit abnormal surface-mediated activation of fibrinolysis. Fitzgerald trait represents a 'true' deficiency of HMWK, whereas Flaujeac and Williams traits represent total kininogen deficiency, in which both HMWK and low molecular weight kininogen (LMWK) are deficient. HMWK and LMWK are both encoded by the KNG1 gene ({612358}) ({1:Bick, 2002}; {13:Takagaki et al., 1985}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Flaujeac Factor Deficiency" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.