Human T-cell leukemia virus type 1

Common Name(s)

Human T-cell leukemia virus type 1

Human T-cell leukemia virus, type 1 (HTLV-1) is a retroviral infection that affect the T cells (a type of white blood cell). Although this virus generally causes no signs or symptoms, some affected people may later develop adult T-cell leukemia (ATL), HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) or other medical conditions. HTLV-1 is spread by blood transfusions, sexual contact and sharing needles. It can also be spread from mother to child during birth or breast-feeding. There is no cure or treatment for HTLV-1 and it is considered a lifelong condition; however, most (95%) infected people remain asymptomatic (show no symptoms) throughout life.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Human T-cell leukemia virus type 1" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Human T-cell leukemia virus type 1" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Human T-cell leukemia virus type 1" returned 428 free, full-text research articles on human participants. First 3 results:

Control of Human T-Cell Leukemia Virus Type 1 (HTLV-1) Infection by Eliminating Envelope Protein-Positive Cells with Recombinant Vesicular Stomatitis Viruses Encoding HTLV-1 Primary Receptor.
 

Author(s): Kenta Tezuka, Kazu Okuma, Madoka Kuramitsu, Sahoko Matsuoka, Reiko Tanaka, Yuetsu Tanaka, Isao Hamaguchi

Journal:

 

Human T-cell leukemia virus type 1 (HTLV-1) infection causes adult T-cell leukemia (ATL), which is frequently resistant to currently available therapies and has a very poor prognosis. To prevent the development of ATL among carriers, it is important to control HTLV-1-infected cells ...

Last Updated: 31 Dec 1969

Go To URL
Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo.
 

Author(s): Rie Furuta, Jun-Ichirou Yasunaga, Michi Miura, Kenji Sugata, Akatsuki Saito, Hirofumi Akari, Takaharu Ueno, Norihiro Takenouchi, Jun-Ichi Fujisawa, Ki-Ryang Koh, Yusuke Higuchi, Mohamed Mahgoub, Masakazu Shimizu, Fumihiko Matsuda, Anat Melamed, Charles R Bangham, Masao Matsuoka

Journal:

 

Human T-cell leukemia virus type 1 (HTLV-1) infects mainly CD4+CCR4+ effector/memory T cells in vivo. However, it remains unknown whether HTLV-1 preferentially infects these T cells or this virus converts infected precursor cells to specialized T cells. Expression of viral genes in ...

Last Updated: 31 Dec 1969

Go To URL
IL-10-mediated signals act as a switch for lymphoproliferation in Human T-cell leukemia virus type-1 infection by activating the STAT3 and IRF4 pathways.
 

Author(s): Leila Sawada, Yoshiko Nagano, Atsuhiko Hasegawa, Hikari Kanai, Kai Nogami, Sayaka Ito, Tomoo Sato, Yoshihisa Yamano, Yuetsu Tanaka, Takao Masuda, Mari Kannagi

Journal:

 

Human T-cell leukemia virus type-1 (HTLV-1) causes two distinct diseases, adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Since there are no disease-specific differences among HTLV-1 strains, the etiological mechanisms ...

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Human T-cell leukemia virus type 1" returned 8 free, full-text review articles on human participants. First 3 results:

Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence.
 

Author(s): Alexandre Carpentier, Pierre-Yves Barez, Malik Hamaidia, Hélène Gazon, Alix de Brogniez, Srikanth Perike, Nicolas Gillet, Luc Willems

Journal:

 

Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes cancer (Adult T cell Leukemia, ATL) and a spectrum of inflammatory diseases (mainly HTLV-associated myelopathy-tropical spastic paraparesis, HAM/TSP). Since virions are particularly unstable, HTLV-1 transmission ...

Last Updated: 31 Dec 1969

Go To URL
Double control systems for human T-cell leukemia virus type 1 by innate and acquired immunity.
 

Author(s): Mari Kannagi, Atsuhiko Hasegawa, Shuichi Kinpara, Yukiko Shimizu, Ayako Takamori, Atae Utsunomiya

Journal: Cancer Sci.. 2011 Apr;102(4):670-6.

 

Human T-cell leukemia virus type 1 (HTLV-1) is the causative retrovirus of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1-specific T-cell responses elicit antitumor and antiviral effects in experimental models, and are considered ...

Last Updated: 31 Dec 1969

Go To URL
Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and therapy.
 

Author(s): M Matsuoka, K-T Jeang

Journal: Oncogene. 2011 Mar;30(12):1379-89.

 

The human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus discovered to be causative of a human cancer, adult T-cell leukemia. The transforming entity of HTLV-1 has been attributed to the virally-encoded oncoprotein, Tax. Unlike the v-onc proteins encoded by other oncogenic ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study of KW-0761 in Subjects With HTLV-1 Associated Myelopathy (HAM)
 

Status: Recruiting

Condition Summary: HTLV-1 Associated Myelopathy

 

Last Updated: 25 Jun 2017

Go to URL
Effect of Raltegravir in Patients With Acute Tropical Spastic Paraparesis - Human T-Lymphotropic Virus 1 Infection
 

Status: Recruiting

Condition Summary: HTLV-I Infections; Tropical Spastic Paraparesis

 

Last Updated: 20 Nov 2017

Go to URL
Evaluation of Patients With HAM/TSP
 

Status: Recruiting

Condition Summary: HTLV-I Infection; Tropical Spastic Paraparesis

 

Last Updated: 20 Apr 2018

Go to URL