Hydatidiform mole, recurrent, 2

Common Name(s)

Hydatidiform mole, recurrent, 2

A hydatidiform mole is an abnormal pregnancy characterized by hydropic placental villi, trophoblastic hyperplasia, and poor fetal development. Familial recurrent hydatidiform mole is an autosomal recessive condition in which women experience recurrent pregnancy losses, predominantly complete hydatidiform mole (CHM). However, unlike sporadic CHMs, which are androgenetic with 2 paternal chromosome complements, CHMs associated with familial recurrence are genetically biparental in origin with both a maternal and a paternal contribution to the genome. Other pregnancy losses in this condition include partial hydatidiform mole, stillbirths, ectopic pregnancies, early neonatal deaths, and miscarriages, some of which may be undiagnosed molar pregnancies. Normal pregnancies are extremely rare in families with this condition (summary by {1:Fallahian et al., 2013}). For a discussion of genetic heterogeneity of recurrent hydatidiform mole, see HYDM1 ({231090}).
 

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Scientific Literature

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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