Hydatidiform mole

Common Name(s)

Hydatidiform mole, Gestational Trophoblastic Neoplasms

Molar pregnancy is a condition in which the placenta does not develop properly. The symptoms of molar pregnancy, which may include vaginal bleeding, severe morning sickness, stomach cramps, and high blood pressure, typically begin around the 10th week of pregnancy. Because the embryo does not form or is malformed in molar pregnancies, and because there is a small risk of developing a cancer called choriocarcinoma, a D&C is usually performed.
 

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Condition Specific Organizations

Following organizations serve the condition "Hydatidiform mole" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hydatidiform mole" returned 105 free, full-text research articles on human participants. First 3 results:

Establishment and characterization of cell lines derived from complete hydatidiform mole.
 

Author(s): Eiko Yamamoto, Kaoru Niimi, Tohru Kiyono, Toshimichi Yamamoto, Kimihiro Nishino, Kenichi Nakamura, Tomomi Kotani, Hiroaki Kajiyama, Kiyosumi Shibata, Fumitaka Kikkawa

Journal: Int. J. Mol. Med.. 2017 Sep;40(3):614-622.

 

Gestational trophoblastic diseases (GTDs) are a group of diseases characterized by abnormal cellular proliferation of atypical trophoblasts. A hydatidiform mole is an abnormal pregnancy caused by genetic fertilization disorders, and it can be classified as a complete hydatidiform ...

Last Updated: 31 Dec 1969

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Uterine artery Doppler flow velocimetry parameters for predicting gestational trophoblastic neoplasia after complete hydatidiform mole, a prospective cohort study.
 

Author(s): Flavia Tarabini Castellani Asmar, Antonio Rodrigues Braga-Neto, Jorge de Rezende-Filho, Juliana Marques Simões Villas-Boas, Rafael Cortés Charry, Izildinha Maesta

Journal: Clinics (Sao Paulo). 2017 May;72(5):284-288.

 

Doppler ultrasonography can be used to assess neoangiogenesis, a characteristic feature of postmolar gestational trophoblastic neoplasia. However, there is limited information on whether uterine artery Doppler flow velocimetry parameters can predict gestational trophoblastic neoplasia ...

Last Updated: 31 Dec 1969

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Trends in ectopic pregnancy, hydatidiform mole and miscarriage in the largest obstetrics and gynaecology hospital in China from 2003 to 2013.
 

Author(s): Xue-Lian Li, Dan-Feng Du, Shang-Jie Chen, Sai-Hua Zheng, Arier C Lee, Qi Chen

Journal:

 

Ectopic pregnancies, miscarriages and hydatidiform moles are the major types of pathological pregnancies in the early gestations of pregnancy and constitute an important public health problem. The trends and incidences of these pathological pregnancies may vary by ethnicity and geographical ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hydatidiform mole" returned 7 free, full-text review articles on human participants. First 3 results:

Accuracy of p57 compared with genotyping for the diagnosis of complete hydatidiform mole: protocol for a systematic review and meta-analysis.
 

Author(s): Jose Mauro Madi, Antonio Rodrigues Braga, Machline Paim Paganella, Isnard Elman Litvin, Eliana Márcia Da Ros Wendland

Journal:

 

Distinguishing hydatidiform moles (HMs) from non-molar specimens and the subclassification of HM are important because complete hydatidiform mole (CHM) is associated with an increased risk of gestational trophoblastic neoplasia. However, diagnosis based solely on morphology has poor ...

Last Updated: 31 Dec 1969

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[Complete hydatidiform mole].
 

Author(s): Jean-Jacques Candelier

Journal: Med Sci (Paris). 2015 Oct;31(10):861-8.

 

"The battle of the sexes begins in the zygote" W. Reik and J. Walter. Complete hydatidiform mole (CHM) is a pathology of the placenta with androgenetic diploid origin (chromosomes only from paternal origin). Placental villi present an abnormal hyperproliferation and hydropic degeneration ...

Last Updated: 31 Dec 1969

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The hydatidiform mole.
 

Author(s): Jean-Jacques Candelier

Journal: Cell Adh Migr. 2016 Mar;10(1-2):226-35.

 

The hydatidiform mole (HM) is a placental pathology of androgenetic origin. Placental villi have an abnormal hyperproliferation event and hydropic degeneration. Three situations can be envisaged at its origin: 1. The destruction/expulsion of the female pronucleus at the time of fertilization ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Comparison of Single Versus Double Evacuation for Treatment of Hydatidiform Mole
 

Status: Recruiting

Condition Summary: Hydatidiform Mole

 

Last Updated: 22 Mar 2016

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Study of the Genetic and Epigenetic Causes of Recurrent Hydatidiform Moles
 

Status: Recruiting

Condition Summary: Hydatidiform Moles

 

Last Updated: 7 Jan 2018

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The French National Reference Centre of GTD
 

Status: Recruiting

Condition Summary: Neoplasm, Trophoblastic; Gestational Trophoblastic Disease; Hydatidiform Mole; Hydatidiform Mole, Invasive

 

Last Updated: 2 Sep 2016

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