Hydrops fetalis

Common Name(s)

Hydrops fetalis

Hydrops fetalis is a serious condition in which abnormal amounts of fluid build up in two or more body areas of a fetus or newborn. There are two types of hydrops fetalis: immune and nonimmune. Immune hydrops fetalis is a complication of a severe form of Rh incompatibility. Rh compatibility causes massive red blood cell destruction, which leads to several problems, including total body swelling. Severe swelling can interfere with how the body organs work. Nonimmune hydrops fetalis occurs when a disease or medical condition disrupts the body's ability to manage fluid. There are three main causes for this type: heart or lung problems, severe anemia (thalassemia), and genetic defects, including Turner syndrome. The exact cause depends on which form a baby has.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hydrops fetalis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hydrops fetalis" returned 95 free, full-text research articles on human participants. First 3 results:

Mesalazine as a cause of fetal anemia and hydrops fetalis: A case report.
 

Author(s): Sverker Ek, Staffan Rosenborg

Journal: Medicine (Baltimore). 2017 Dec;96(50):e9277.

 

Mesalazine and its prodrug sulfasalazine are both used for inflammatory bowel disease. Sulfasalazine has been associated with hematological side-effects such as aplastic and hemolytic anemia in patients, but also in fetuses after intrauterine exposure. To our knowledge, we describe ...

Last Updated: 31 Dec 1969

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A 6-year-old girl diagnosed with mevalonate kinase deficiency who had hydrops fetalis and neonatal-onset cholestasis.
 

Author(s): Yuriko Yamashita, Shinsuke Matsumoto, Ryugo Hiramoto, Isao Komori, Takayuki Tanaka, Ryuta Nishikomori, Toshio Heike, Shuichiro Umetsu, Ayano Inui

Journal: Nihon Rinsho Meneki Gakkai Kaishi. 2017 ;40(2):131-137.

 

We experienced a 6-year-old girl diagnosed with mevalonate kinase deficiency (MKD) who had cholestasis, anemia, and elevated inflammatory markers in neonatal period. She was admitted to our hospital because of fever and elevated inflammatory markers at 5 years 11months of age. Without ...

Last Updated: 31 Dec 1969

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Genetic origin of α-thalassemia (SEA deletion) in Southeast Asian populations and application to accurate prenatal diagnosis of Hb Bart's hydrops fetalis syndrome.
 

Author(s): Wittaya Jomoui, Goonnapa Fucharoen, Kanokwan Sanchaisuriya, Patnaree Charoenwijitkul, Jitpanu Maneesarn, Xiangmin Xu, Supan Fucharoen

Journal: J. Hum. Genet.. 2017 Aug;62(8):747-754.

 

α-thalassemia of SEA deletion (-) is common among Southeast Asian and Chinese. Using haplotype and phylogenetic analyses, we examined the origin of this defect in Southeast Asian populations. Study was done on both normal and α-thalassemia alleles in 3 ethnic groups including 96 ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hydrops fetalis" returned 5 free, full-text review articles on human participants. First 3 results:

An international registry of survivors with Hb Bart's hydrops fetalis syndrome.
 

Author(s): Duantida Songdej, Christian Babbs, Douglas R Higgs,

Journal: Blood. 2017 03;129(10):1251-1259.

 

Hemoglobin (Hb) Bart's hydrops fetalis syndrome (BHFS) resulting from α-thalassemia is considered a universally fatal disorder. However, over the last 3 decades, improvements in intrauterine interventions and perinatal intensive care have resulted in increasing numbers of BHFS survivors. ...

Last Updated: 31 Dec 1969

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Lysosomal storage disorder in non-immunological hydrops fetalis (NIHF): more common than assumed? Report of four cases with transient NIHF and a review of the literature.
 

Author(s): Catharina Whybra, Eugen Mengel, Alexandra Russo, Franz Bahlmann, Christoph Kampmann, Michael Beck, Elke Eich, Eva Mildenberger

Journal:

 

Lysosomal storage disorders (LSD) are a rare cause of non immunological hydrops fetalis (NIHF) and congenital ascites. The reported incidence is about 1%. The incidence of idiopathic NIHF is estimated to be about 18%.

Last Updated: 31 Dec 1969

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Hydrops fetalis caused by homozygous alpha-thalassemia and Rh antigen alloimmunization: report of a survivor and literature review.
 

Author(s): Divya-Devi Joshi, H James Nickerson, Michael J McManus

Journal: Clin Med Res. 2004 Nov;2(4):228-32.

 

Hematologic causes of hydrops fetalis include homozygous alpha-thalassemia and immune hemolytic anemias. We report the case of a boy with hydrops fetalis who had homozygous alpha-thalassemia and alloimmune hemolytic anemia due to anti-E and anti-C blood group antibodies. He received ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 9 Dec 2016

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Fetal Birth Defects: Toward a Precision-based Approach
 

Status: Recruiting

Condition Summary: Hydrops Fetalis; Birth Defect; Fetal Anomaly

 

Last Updated: 11 Oct 2018

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EPO-4-Rhesus Study
 

Status: Recruiting

Condition Summary: Erythroblastosis, Fetal; Erythroblastosis Fetalis, Rh Disease; Erythroblastosis Fetalis Due to RH Antibodies; Erythroblastosis Fetalis Due to Isoimmunization

 

Last Updated: 16 Sep 2018

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