Idiopathic gastroparesis

Common Name(s)

Idiopathic gastroparesis

Idiopathic gastroparesis is a condition in which the stomach muscles do not work correctly. When food moves into the stomach, muscles contract and relax methodically to break down the food before it passes into the small intestine. If the stomach muscles do not work correctly, food does not move on to the small intestine, causing problems with digestion. Idiopathic means the cause is unknown and is the most common type. Sometimes gastroparesis may get better on its own but more often it is a lifelong condition (chronic).

Symptoms include vomiting, nausea, feeling full after just a few bites, bloating, abdominal pain, lack of appetite, malnutrition, and changes in blood sugar levels. Complications include severe dehydration, malnutrition, and blood sugar fluctuations. The cause of idiopathic gastroparesis seems to involve damage to the nerve that controls stomach muscles (the vagus nerve).

Risk factors include abdominal or esophageal surgery, radiation therapy, infection, narcotic pain medications, and hypothyroidism (low thyroid function). Certain conditions such as Ehlers Danlos syndrome, postural orthostatic tachycardia syndrome, scleroderma, multiple sclerosis and Parkinson disease also increase a person’s risk. Idiopathic gastroparesis is more likely to affect young and middle aged women.

Diagnosis may include and upper GI scan, MRI, CT scan, special breath test, stomach emptying test and/or an endoscopy. There is no cure for gastroparesis and the treatments may not help everyone. Treatments may include diet changes, medication, and/or devices or procedures that help move the digested food through the stomach and controlling underlying causes. If you or a family member has been diagnosed with gastroparesis, talk to your doctor and specialists about the most current treatment options. Support groups are a good source for information and will help connect you with others living with gastroparesis.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Idiopathic gastroparesis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Idiopathic gastroparesis" returned 17 free, full-text research articles on human participants. First 3 results:

Repeat polymorphisms in the Homo sapiens heme oxygenase-1 gene in diabetic and idiopathic gastroparesis.
 

Author(s): Simon J Gibbons, Madhusudan Grover, Kyoung Moo Choi, Akhilesh Wadhwa, Adeel Zubair, Laura A Wilson, Yanhong Wu, Thomas L Abell, William L Hasler, Kenneth L Koch, Richard W McCallum, Linda A B Nguyen, Henry P Parkman, Irene Sarosiek, William J Snape, James Tonascia, Frank A Hamilton, Pankaj J Pasricha, Gianrico Farrugia

Journal:

 

Idiopathic and diabetic gastroparesis in Homo sapiens cause significant morbidity. Etiology or risk factors have not been clearly identified. Failure to sustain elevated heme oxygenase-1 (HO1) expression is associated with delayed gastric emptying in diabetic mice and polymorphisms ...

Last Updated: 31 Dec 1969

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Diabetic and idiopathic gastroparesis is associated with loss of CD206-positive macrophages in the gastric antrum.
 

Author(s): M Grover, C E Bernard, P J Pasricha, H P Parkman, S J Gibbons, J Tonascia, K L Koch, R W McCallum, I Sarosiek, W L Hasler, L A B Nguyen, T L Abell, W J Snape, M L Kendrick, T A Kellogg, T J McKenzie, F A Hamilton, G Farrugia,

Journal: Neurogastroenterol. Motil.. 2017 Jun;29(6):.

 

Animal studies have increasingly highlighted the role of macrophages in the development of delayed gastric emptying. However, their role in the pathophysiology of human gastroparesis is unclear. Our aim was to determine changes in macrophages and other cell types in the gastric antrum ...

Last Updated: 31 Dec 1969

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Nausea and vomiting in gastroparesis: similarities and differences in idiopathic and diabetic gastroparesis.
 

Author(s): H P Parkman, E K Hallinan, W L Hasler, G Farrugia, K L Koch, J Calles, W J Snape, T L Abell, I Sarosiek, R W McCallum, L Nguyen, P J Pasricha, J Clarke, L Miriel, L Lee, J Tonascia, F Hamilton,

Journal: Neurogastroenterol. Motil.. 2016 Dec;28(12):1902-1914.

 

Nausea and vomiting are classic symptoms of gastroparesis. It remains unclear if characteristics of nausea and vomiting are similar in different etiologies of gastroparesis. The aims of this article were as follows: to describe characteristics of nausea and vomiting in patients with ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Idiopathic gastroparesis" returned 1 free, full-text review articles on human participants. First 3 results:

Idiopathic gastroparesis.
 

Author(s): Henry P Parkman

Journal: Gastroenterol. Clin. North Am.. 2015 Mar;44(1):59-68.

 

Gastroparesis is a chronic symptomatic disorder of the stomach characterized by delayed emptying without evidence of mechanical obstruction. Idiopathic gastroparesis refers to gastroparesis of unknown cause not from diabetes; not from prior gastric surgery; not related to other endocrine, ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effect of TAK-954 on Gastrointestinal and Colonic Transit in Diabetic or Idiopathic Gastroparesis Participants
 

Status: Recruiting

Condition Summary: Diabetic Gastroparesis; Idiopathic Gastroparesis

 

Last Updated: 5 Jan 2018

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A Pilot Study on the Efficacy and Safety of Olanzapine in Gastroparesis
 

Status: Recruiting

Condition Summary: Idiopathic Gastroparesis

 

Last Updated: 26 Jun 2018

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A Study to Evaluate the Efficacy and Safety of TAK-906 in Adult Participants With Symptomatic Idiopathic or Diabetic Gastroparesis
 

Status: Not yet recruiting

Condition Summary: Diabetic Gastroparesis; Idiopathic Gastroparesis

 

Last Updated: 10 Sep 2018

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