Inflammatory breast cancer

Common Name(s)

Inflammatory breast cancer, Breast cancer, inflammatory

Inflammatory breast cancer is a rare and rapidly developing cancer that affects the breasts. This form of breast cancer can cause rapid changes in the appearance of the breast over the course of several weeks, including enlargement of the breast, discoloration (red, purple, pink, or bruised appearance), dimpling or ridges on the skin of the affected breast (similar to an orange peel), and flatting or turning inward of the nipple. Symptoms can also include breast tenderness, pain or aching, enlarged lymph nodes under the arm, as well as a thickness and heaviness to the breast. In some cases, there may be an unusual warmth in the affected breast.

The exact cause of inflammatory breast cancer is unknown. Like all forms of cancer, inflammatory breast cancer starts with a mutation (change) within the DNA of a cell within the breast. Because of this genetic change, this abnormal cell then grows and divides faster than it should, causing a blockage of the vessels that filter and transport fluids away from breast tissue (lymphatic vessels). This blockage and buildup of fluid causes the red and swollen appearance of the breast. Risk factors for inflammatory breast cancer include gender (woman are diagnosed with inflammatory breast cancer more than men), ethnicity (black women have a higher risk), weight (obesity increases the risk of cancer), and age (the older you are, the higher your risk for inflammatory breast cancer).

A doctor can diagnose inflammatory breast cancer by performing a physical exam, collecting images of the breast (using a mammogram (breast X-ray) or breast ultrasound), and removing a sample of tissue for testing (biopsy). Treatment of inflammatory breast cancer can include chemotherapy (chemical treatment), surgery, radiation therapy, and hormone therapy. It is important to talk to your doctor if you or someone you know has been diagnosed with inflammatory breast cancer to determine the best treatment plan.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Inflammatory breast cancer" for support, advocacy or research.

Inflammatory Breast Cancer Research Foundation

Our mission is to assist scientists and researchers in their quest to determine the definitive causes of inflammatory breast cancer. The Inflammatory Breast Cancer Research Foundation seeks to assist them in their work so effective and meaningful detection and diagnosis, prevention and treatment can be pursued and achieved.

Last Updated: 29 Apr 2014

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Bay Area Cancer Connections

We support people touched by breast and ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

Last Updated: 21 May 2015

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

Last Updated: 26 Dec 2012

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Kommah Seray Inflammatory Breast Cancer Foundation

To raise awareness of Inflammatory Breast Cancer and meet the immediate needs of active cancer patients by providing assistance and support. Additionally, the foundation will work toward educating medical professionals and the community at large on how to detect Inflammatory Breast Cancer.

Last Updated: 26 Mar 2013

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Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

Last Updated: 6 Nov 2012

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Inflammatory breast cancer" for support, advocacy or research.

Inflammatory Breast Cancer Research Foundation

Our mission is to assist scientists and researchers in their quest to determine the definitive causes of inflammatory breast cancer. The Inflammatory Breast Cancer Research Foundation seeks to assist them in their work so effective and meaningful detection and diagnosis, prevention and treatment can be pursued and achieved.

http://www.ibcresearch.org

Last Updated: 29 Apr 2014

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Bay Area Cancer Connections

We support people touched by breast and ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

http://www.bcconnections.org

Last Updated: 21 May 2015

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

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Kommah Seray Inflammatory Breast Cancer Foundation

To raise awareness of Inflammatory Breast Cancer and meet the immediate needs of active cancer patients by providing assistance and support. Additionally, the foundation will work toward educating medical professionals and the community at large on how to detect Inflammatory Breast Cancer.

http://www.ksibcf.org

Last Updated: 26 Mar 2013

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Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

http://stupidcancer.org

Last Updated: 6 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Inflammatory breast cancer" returned 356 free, full-text research articles on human participants. First 3 results:

Clinically relevant inflammatory breast cancer patient-derived xenograft-derived ex vivo model for evaluation of tumor-specific therapies.
 

Author(s): Bedrich L Eckhardt, Maria Gagliardi, LaKesla Iles, Kurt Evans, Cristina Ivan, Xiuping Liu, Chang-Gong Liu, Glauco Souza, Arvind Rao, Funda Meric-Bernstam, Naoto T Ueno, Geoffrey A Bartholomeusz

Journal:

 

Inflammatory breast cancer (IBC) is a rare and aggressive presentation of invasive breast cancer with a 62% to 68% 5-year survival rate. It is the most lethal form of breast cancer, and early recognition and treatment is important for patient survival. Like non-inflammatory breast ...

Last Updated: 31 Dec 1969

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Dermoscopy of inflammatory breast cancer.
 

Author(s): María Gabriela Vallone, Virginia Mariana González, José Gabriel Casas, Margarita Larralde

Journal: An Bras Dermatol. 2018 Mar;93(2):289-290.

 

Inflammatory breast cancer is an aggressive and infiltrative malignancy that is often misdiagnosed as an infection because of its symptoms and signs of inflammation, delaying proper diagnosis and treatment. We report a case of inflammatory breast cancer showing correlation between ...

Last Updated: 31 Dec 1969

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Gene set analysis of post-lactational mammary gland involution gene signatures in inflammatory and triple-negative breast cancer.
 

Author(s): Arvind Bambhroliya, Renae D Van Wyhe, Swaminathan Kumar, Bisrat G Debeb, Jay P Reddy, Steve Van Laere, Randa El-Zein, Arvind Rao, Wendy A Woodward

Journal:

 

Epidemiological studies have found that triple-negative breast cancer (TNBC) and TN inflammatory breast cancer (IBC) are associated with lower frequency and duration of breast-feeding compared to non-TNBC and non-TN IBC, respectively. Limited breast-feeding could reflect abrupt or ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Inflammatory breast cancer" returned 29 free, full-text review articles on human participants. First 3 results:

Challenging a Misnomer? The Role of Inflammatory Pathways in Inflammatory Breast Cancer.
 

Author(s): Riley J Morrow, Nima Etemadi, Belinda Yeo, Matthias Ernst

Journal: Mediators Inflamm.. 2017 ;2017():4754827.

 

Inflammatory breast cancer is a rare, yet highly aggressive form of breast cancer, which accounts for less than 5% of all locally advanced presentations. The clinical presentation of inflammatory breast cancer often differs significantly from that of noninflammatory breast cancer; ...

Last Updated: 31 Dec 1969

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Developmental therapeutics for inflammatory breast cancer: Biology and translational directions.
 

Author(s): Ricardo Costa, Cesar A Santa-Maria, Giovanna Rossi, Benedito A Carneiro, Young Kwang Chae, William J Gradishar, Francis J Giles, Massimo Cristofanilli

Journal: Oncotarget. 2017 Feb;8(7):12417-12432.

 

Inflammatory breast cancer (IBC) is a rare and aggressive form of breast cancer, which accounts for approximately 3% of cases of breast malignancies. Diagnosis relies largely on its clinical presentation, and despite a characteristic phenotype, underlying molecular mechanisms are ...

Last Updated: 31 Dec 1969

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Effects of Exercise on Insulin, IGF Axis, Adipocytokines, and Inflammatory Markers in Breast Cancer Survivors: A Systematic Review and Meta-analysis.
 

Author(s): Dong-Woo Kang, Junga Lee, Sang-Hoon Suh, Jennifer Ligibel, Kerry S Courneya, Justin Y Jeon

Journal: Cancer Epidemiol. Biomarkers Prev.. 2017 03;26(3):355-365.

 

Insulin, IGF axis, adiponectin, and inflammatory markers are associated with breast cancer. Given that physical activity improves prognosis of breast cancer survivors, we investigated the effects of exercise on these markers as potential mediators between physical activity and breast ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study Of Ruxolitinib (INCB018424) With Preoperative Chemotherapy For Triple Negative Inflammatory Breast Cancer
 

Status: Recruiting

Condition Summary: Inflammatory Breast Cancer (IBC)

 

Last Updated: 20 May 2018

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Study of Immunotherapy in Combination With Chemotherapy in HER2-negative Inflammatory Breast Cancer
 

Status: Not yet recruiting

Condition Summary: Inflammatory Breast Cancer

 

Last Updated: 3 May 2018

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A Phase 2 Study of Eribulin Followed by AC as Preoperative Therapy for HER2-negative Inflammatory Breast Cancer
 

Status: Recruiting

Condition Summary: Inflammatory Breast Cancer; Human Epidermal Growth Factor 2 Negative Carcinoma of Breast

 

Last Updated: 20 May 2018

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