Internal carotid agenesis

Common Name(s)

Internal carotid agenesis

Internal carotid agenesis occurs when one of the blood vessels which supply blood to the brain does not develop (agenesis).  It is rare, occurring in less than 0.01% of people.   Usually there is a pair of internal carotid arteries, one on the left side and one on the right side; agenesis occurs on the left side three times more frequently than on the right side.  Individuals with this condition may not have any symptoms because there are several blood vessels transporting blood to the brain such that if one does not develop, the others can function in its place.  However, if symptoms occur, they may include headache, blurred vision, paralysis of some of the nerves in the head (palsy), epilepsy, or muscle weakness on one side of the body (hemiparesis).   The main concern with internal carotid agenesis is the increased risk for enlargement of the other blood vessels (aneurysm), which can occur in up to 67% of people with this condition (compared to 2-4% of individuals without this condition).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Internal carotid agenesis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Internal carotid agenesis" returned 29 free, full-text research articles on human participants. First 3 results:

[Acute abducens nerve palsy as a result of bilateral internal carotid artery agenesis].
 

Author(s): J Bordet, I Larré, C Arndt, C Brugniart, D Benisty, A Ducasse

Journal: J Fr Ophtalmol. 2016 Apr;39(4):e109-11.

 

Last Updated: 31 Dec 1969

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Left internal carotid artery agenesis with trans-sellar collateral and a right aortic arch: Case report.
 

Author(s): Masakazu Okawa, Toshio Higashi, Masaki Komiyama, Kenji Fukuda, Hiroshi Abe, Tooru Inoue

Journal: Interv Neuroradiol. 2015 Dec;21(6):759-64.

 

We present a case of unilateral internal carotid artery (ICA) agenesis with trans-sellar anastomosis associated with a right aortic arch, and discuss the embryonic development and clinical implications of this condition. A 26-year-old woman without significant medical history was ...

Last Updated: 31 Dec 1969

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Congenital aural atresia associated with agenesis of internal carotid artery in a girl with a FOXI3 deletion.
 

Author(s): Elisa Tassano, Vidhya Jagannathan, Cord Drögemüller, Massimiliano Leoni, Marjo K Hytönen, Mariasavina Severino, Stefania Gimelli, Cristina Cuoco, Maja Di Rocco, Kirsi Sanio, Andrew K Groves, Tosso Leeb, Giorgio Gimelli

Journal: Am. J. Med. Genet. A. 2015 Mar;167A(3):537-44.

 

We report on the molecular characterization of a microdeletion of approximately 2.5 Mb at 2p11.2 in a female baby with left congenital aural atresia, microtia, and ipsilateral internal carotid artery agenesis. The deletion was characterized by fluorescence in situ hybridization, ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Internal carotid agenesis" returned 2 free, full-text review articles on human participants. First 3 results:

Internal carotid artery agenesis: A case report and review of literature.
 

Author(s): Shuo Li, Kusum Hooda, Nishant Gupta, Yogesh Kumar

Journal: Neuroradiol J. 2017 Apr;30(2):186-191.

 

Congenital agenesis of the internal carotid artery is a very rare anomaly. Intracranial circulation in the involved internal carotid artery territory is maintained by collateral circulation from the contralateral internal carotid artery through the anterior communicating artery and ...

Last Updated: 31 Dec 1969

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Agenesis of internal carotid artery associated with isolated growth hormone deficiency: a case report and literature review.
 

Author(s): Stefano Stagi, Giovanna Traficante, Elisabetta Lapi, Marilena Pantaleo, Sabrina Becciani, Marzia Mortilla, Salvatore Seminara, Maurizio de Martino

Journal:

 

Agenesis of the internal carotid artery (ICA) is a rare congenital abnormality, sporadically reported to be associated with a combined congenital hypopituitarism. Nevertheless, only a few cases have been extensively described, and none of these have been characterized by an isolated ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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