Intestinal pseudo-obstruction

Common Name(s)

Intestinal pseudo-obstruction

Intestinal pseudo-obstruction is a digestive disorder in which the intestinal walls are unable to contract normally (called hypomotility); the condition resembles a true obstruction, but no actual blockage exists. Signs and symptoms may include abdominal pain; vomiting; diarrhea; constipation; malabsorption of nutrients leading to weight loss and/or failure to thrive; and other symptoms. It may be classified as neuropathic (from lack of nerve function) or myopathic (from lack of muscle function), depending on the source of the abnormality. The condition is sometimes inherited (in an X-linked recessive or autosomal dominant manner) and may be caused by mutations in the FLNA gene; it may also be acquired after certain illnesses. The goal of treatment is to provide relief from symptoms and ensure that nutritional support is adequate.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Intestinal pseudo-obstruction" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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G-PACT

G-PACT is dedicated to increasing awareness of gastroparesis (GP), chronic intestinal pseudo obstruction (CIP), and colonic inertia (CI) among medical professionals, patients, and the general population. We are working towards finding a cure and/or better treatment options for people dealing with DTP. We provide educational resources, multiple support programs, patient advocacy programs, and other aid as needed to help patients cope and to provide hope to everyone afflicted with the condition.

Last Updated: 28 Apr 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Intestinal pseudo-obstruction" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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G-PACT

G-PACT is dedicated to increasing awareness of gastroparesis (GP), chronic intestinal pseudo obstruction (CIP), and colonic inertia (CI) among medical professionals, patients, and the general population. We are working towards finding a cure and/or better treatment options for people dealing with DTP. We provide educational resources, multiple support programs, patient advocacy programs, and other aid as needed to help patients cope and to provide hope to everyone afflicted with the condition.

http://www.g-pact.org

Last Updated: 28 Apr 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Intestinal pseudo-obstruction" returned 91 free, full-text research articles on human participants. First 3 results:

Chronic Intestinal Pseudo-obstruction and Orthostatic Hypotension Associated with Small Cell Lung Cancer that Improved with Tumor Reduction after Chemoradiotherapy.
 

Author(s): Yusuke Izumi, Takeshi Masuda, Yasushi Horimasu, Taku Nakashima, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori

Journal: Intern. Med.. 2017 Oct;56(19):2627-2631.

 

Chronic intestinal pseudo-obstruction (CIPO) is a rare disease with symptoms of ileus without obstruction. Most cases of CIPO are idiopathic, and CIPO as a paraneoplastic neurological syndrome (PNS) associated with small cell lung cancer (SCLC) is rare. A 63-year-old man was diagnosed ...

Last Updated: 31 Dec 1969

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Familial Pernicious Chronic Intestinal Pseudo-obstruction with a Mitochondrial DNA A3243G Mutation.
 

Author(s): Junichiro Suzuki, Mai Iwata, Hideyuki Moriyoshi, Suguru Nishida, Takeshi Yasuda, Yasuhiro Ito

Journal: Intern. Med.. 2017 ;56(9):1089-1093.

 

We report the case of a mother and two children who shared a mitochondrial DNA A3243G mutation. The mother had diabetes mellitus, neurogenic bladder, bradykinesia, dystonia, and slowly progressive cerebellar ataxia. Her two daughters were diagnosed with mitochondrial myopathy, encephalopathy, ...

Last Updated: 31 Dec 1969

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Urinary glutamine/glutamate ratio as a potential biomarker of pediatric chronic intestinal pseudo-obstruction.
 

Author(s): Jun-Kai Yan, Ke-Jun Zhou, Jian-Hu Huang, Qing-Qing Wu, Tian Zhang, Chao-Chen Wang, Wei Cai

Journal:

 

Chronic intestinal pseudo-obstruction (CIPO) is a rare intestinal motility disorder with significant morbidity and mortality in pediatric patients. The diagnosis of CIPO is difficult, because it is clinically based on the symptoms and signs of bowel obstruction which are similar to ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Intestinal pseudo-obstruction" returned 13 free, full-text review articles on human participants. First 3 results:

Abnormal layering of muscularis propria as a cause of chronic intestinal pseudo-obstruction: A case report and literature review.
 

Author(s): Napat Angkathunyakul, Suporn Treepongkaruna, Sani Molagool, Nichanan Ruangwattanapaisarn

Journal: World J. Gastroenterol.. 2015 Jun;21(22):7059-64.

 

Visceral myopathy is one of the causes of chronic intestinal pseudo-obstruction. Most cases pathologically reveal degenerative changes of myocytes or muscularis propia atrophy and fibrosis. Abnormal layering of muscularis propria is extremely rare. We report a case of a 9-mo-old Thai ...

Last Updated: 31 Dec 1969

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Intestinal pseudo-obstruction in systemic lupus erythematosus: a case report and review of the literature.
 

Author(s): Jian-lin Wang, Gang Liu, Tong Liu, Jiang-peng Wei

Journal: Medicine (Baltimore). 2014 Dec;93(29):e248.

 

Intestinal pseudo-obstruction (IPO) is a rare but dangerous complication of systemic lupus erythematosus (SLE) when the patient has no other manifestations except gastrointestinal symptoms. We performed 1 patient with a 2-month history of recurrent vomiting and abdominal distension. ...

Last Updated: 31 Dec 1969

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Intestinal pseudo-obstruction as a complication of paragangliomas: case report and literature review.
 

Author(s): T E Osinga, M N Kerstens, M M van der Klauw, J J Koornstra, B H R Wolffenbuttel, T P Links, A N A van der Horst-Schrivers

Journal: Neth J Med. 2013 Dec;71(10):512-7.

 

Intestinal pseudo-obstruction is a rare and relatively unknown complication of phaeochromocytoma√∑ paraganglioma (PCC√∑PGL). Its pathophysiology can be explained by the hypersecretion of catecholamines, which may reduce the peristaltic activity of the gastrointestinal tract. Clinically, ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effects of Laser Acupuncture Therapy on Paralytic Ileus
 

Status: Recruiting

Condition Summary: Paralytic Ileus

 

Last Updated: 5 Feb 2017

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Therapeutic Oxygen for Gastrointestinal Atony (TOGA)
 

Status: Recruiting

Condition Summary: Ileus; Ogilvie Syndrome; Small Bowel Obstruction

 

Last Updated: 26 Jan 2018

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Neuro-Immune Interactions in the Gut
 

Status: Recruiting

Condition Summary: Hirschsprung's Disease Associated Enterocolitis

 

Last Updated: 31 Jul 2018

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