Intrinsic factor deficiency

Common Name(s)

Intrinsic factor deficiency

Congenital pernicious anemia (PA), or intrinsic factor deficiency, is a rare disorder characterized by the lack of gastric intrinsic factor in the presence of normal acid secretion and mucosal cytology and the absence of GIF antibodies that are found in the acquired form of pernicious anemia ({170900}). See also pernicious anemia due to defect in the receptor for vitamin B12/intrinsic factor ({261100}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Intrinsic factor deficiency" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Intrinsic factor deficiency" returned 8 free, full-text research articles on human participants. First 3 results:

Vitamin B12 deficiency in a 15-year old boy due to mutations in the intrinsic factor gene, GIF.
 

Author(s): Ulrik M Overgaard, Stephan M Tanner, Henrik S Birgens

Journal: Br. J. Haematol.. 2010 Aug;150(3):369-71.

 

Last Updated: 31 Dec 1969

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Juvenile cobalamin deficiency in individuals of African ancestry is caused by a founder mutation in the intrinsic factor gene GIF.
 

Author(s): Andrea E Ament, Zhongyuan Li, Amy C Sturm, James D Perko, Sarah Lawson, Margaret Masterson, Edward V Quadros, Stephan M Tanner

Journal: Br. J. Haematol.. 2009 Feb;144(4):622-4.

 

Last Updated: 31 Dec 1969

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The effect of recombinant human intrinsic factor on the uptake of vitamin B12 in patients with evident vitamin B12 deficiency.
 

Author(s): Anne-Mette Hvas, Hora Buhl, Niels Bech Laursen, Birger Hesse, Lars Berglund, Ebba Nexo

Journal: Haematologica. 2006 Jun;91(6):805-8.

 

We report on the use of recombinant human intrinsic factor (rhIF) in a new vitamin B12 absorption test. Holotranscobalamin (holoTC) was measured before and 24 hours after intake of three 9-mg doses of vitamin B12 (B12) and again 24 hours after intake of the same dose of B12 together ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

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The terms "Intrinsic factor deficiency" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Megadose of Hydroxocobalamin for the Treatment of Pernicious Anemia
 

Status: Recruiting

Condition Summary: Megaloblastic Anemia Nos; Pernicious Anemia

 

Last Updated: 27 Dec 2017

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