Juvenile Huntington disease

Common Name(s)

Juvenile Huntington disease

Juvenile Huntington disease (HD) is a less common, early-onset form of Huntington disease that begins in childhood or adolescence. It is also a progressive disorder that causes the breakdown of brain cells in certain areas of the brain. This results in uncontrolled movements, loss of intellectual abilities, and emotional disturbances. Juvenile HD is defined by the onset of symptoms before age 20 years and accounts for 5-10% of HD cases. It is inherited in an autosomal dominant pattern and is caused by a large number of CAG trinucleotide repeats in the HTT gene. A larger number of repeats is usually associated with an earlier onset of signs and symptoms. Most often, children with juvenile HD inherit the expanded CAG trinucleotide repeat from their fathers, although on occasion they inherit it from their mothers.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Juvenile Huntington disease" for support, advocacy or research.

Isabella's Aviary Alliance, LLC

Isabella’s Aviary Alliance, LLC actively demonstrates, through Isabella’s passionate and loving care in breeding and raising baby parrots for other special needs children, the possibility for two hearts—bird and child—coming together and connecting in a way which infinitely brightens the lives of both.

Last Updated: 2 Aug 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Juvenile Huntington disease" for support, advocacy or research.

Isabella's Aviary Alliance, LLC

Isabella’s Aviary Alliance, LLC actively demonstrates, through Isabella’s passionate and loving care in breeding and raising baby parrots for other special needs children, the possibility for two hearts—bird and child—coming together and connecting in a way which infinitely brightens the lives of both.

http://www.isabellasaviary.com

Last Updated: 2 Aug 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Juvenile Huntington disease" returned 5 free, full-text research articles on human participants. First 3 results:

Juvenile Huntington disease in Argentina.
 

Author(s): Emilia Mabel Gatto, Virginia Parisi, José Luis Etcheverry, Ana Sanguinetti, Lorena Cordi, Adrian Binelli, Gabriel Persi, Ferdinando Squitieri

Journal: Arq Neuropsiquiatr. 2016 Jan;74(1):50-4.

 

We analyzed demographic, clinical and genetic characteristics of juvenile Huntington disease (JHD) and it frequency in an Argentinean cohort. Age at onset was defined as the age at which behavioral, cognitive, psychiatric or motor abnormalities suggestive of JHD were first reported. ...

Last Updated: 13 Feb 2016

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Photoclinic. Juvenile Huntington disease.
 

Author(s): Prashant S Naphade, Abhishek R Keraliya, Hina J Shah, Vikram R Lele

Journal: Arch Iran Med. 2013 Oct;16(10):611-2.

 

Last Updated: 7 Oct 2013

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Intergeneration CAG expansion in a Wuhan juvenile-onset Huntington disease family.
 

Author(s): Yuan Liu, Yan Shen, He Li, Hui Wang, Zhen-Rong Yang, Yan Chen, Yan-Ping Tang

Journal: Neurosci Bull. 2007 Jul;23(4):198-202.

 

To make early diagnosis of IT15 gene mutation in a Wuhan juvenile-onset Huntington disease (HD) family, for providing them with genetic counseling, and making preparation for the further research on pathogenesis and experimental therapy of HD.

Last Updated: 9 Aug 2007

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Juvenile Huntington disease" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Growth and Development of the Striatum in Huntington's Disease
 

Status: Recruiting

Condition Summary: Huntington's Disease

 

Last Updated: 31 May 2017

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