Juvenile myoclonic epilepsy

Common Name(s)

Juvenile myoclonic epilepsy

Juvenile myoclonic epilepsy is an epilepsy syndrome characterized by myoclonic jerks (quick jerks of the arms or legs), generalized tonic-clonic seizures (GTCSs), and sometimes, absence seizures.  The seizures of juvenile myoclonic epilepsy often occur when people first awaken in the morning, especially if they are sleep-deprived. Drinking alcohol and psychological stress may also make these seizures more likely.  Onset typically occurs around adolesence in otherwise healthy children.  The exact cause of juvenile myoclonic epilepsy remains unknown.  Although patients usually require lifelong treatment with anticonvulsants, their overall prognosis is generally good.


 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Juvenile myoclonic epilepsy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Juvenile myoclonic epilepsy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Juvenile myoclonic epilepsy" returned 168 free, full-text research articles on human participants. First 3 results:

Variant Intestinal-Cell Kinase in Juvenile Myoclonic Epilepsy.
 

Author(s): Julia N Bailey, Laurence de Nijs, Dongsheng Bai, Toshimitsu Suzuki, Hiroyuki Miyamoto, Miyabi Tanaka, Christopher Patterson, Yu-Chen Lin, Marco T Medina, María E Alonso, José M Serratosa, Reyna M Durón, Viet H Nguyen, Jenny E Wight, Iris E Martínez-Juárez, Adriana Ochoa, Aurelio Jara-Prado, Laura Guilhoto, Yolly Molina, Elsa M Yacubian, Minerva López-Ruiz, Yushi Inoue, Sunao Kaneko, Shinichi Hirose, Makiko Osawa, Hirokazu Oguni, Shinji Fujimoto, Thierry M Grisar, John M Stern, Kazuhiro Yamakawa, Bernard Lakaye, Antonio V Delgado-Escueta

Journal: N. Engl. J. Med.. 2018 03;378(11):1018-1028.

 

In juvenile myoclonic epilepsy, data are limited on the genetic basis of networks promoting convulsions with diffuse polyspikes on electroencephalography (EEG) and the subtle microscopic brain dysplasia called microdysgenesis.

Last Updated: 31 Dec 1969

Go To URL
Subcortical grey matter changes in juvenile myoclonic epilepsy.
 

Author(s): Ji Hyun Kim, Jung Bin Kim, Sang-Il Suh, Dong Wook Kim

Journal:

 

Recent neuroimaging studies have provided converging evidence of structural and functional abnormalities of the thalamus in patients with juvenile myoclonic epilepsy (JME). There has also been limited evidence indicating involvement of the subcortical grey matter structures other ...

Last Updated: 31 Dec 1969

Go To URL
Sleep abnormalities in juvenile myoclonic epilepsy-A sleep questionnaire and polysomnography based study.
 

Author(s): Sujata Roshan, Vinod Puri, Neera Chaudhry, Anu Gupta, Sumit Kumar Rabi

Journal: Seizure. 2017 Aug;50():194-201.

 

To evaluate the quality of sleep, its architecture and occurrence of epileptiform discharges with their distribution across various stages of sleep in patients of Juvenile myoclonic epilepsy (JME), both drug naïve as well as those already on treatment.

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Juvenile myoclonic epilepsy" returned 12 free, full-text review articles on human participants. First 3 results:

Genetic susceptibility in Juvenile Myoclonic Epilepsy: Systematic review of genetic association studies.
 

Author(s): Bruna Priscila Dos Santos, Chiara Rachel Maciel Marinho, Thalita Ewellyn Batista Sales Marques, Layanne Kelly Gomes Angelo, Maísa Vieira da Silva Malta, Marcelo Duzzioni, Olagide Wagner de Castro, João Pereira Leite, Fabiano Timbó Barbosa, Daniel Leite Góes Gitaí

Journal:

 

Several genetic association investigations have been performed over the last three decades to identify variants underlying Juvenile Myoclonic Epilepsy (JME). Here, we evaluate the accumulating findings and provide an updated perspective of these studies.

Last Updated: 31 Dec 1969

Go To URL
Juvenile myoclonic epilepsy as a spectrum disorder: A focused review.
 

Author(s): Betül Baykan, Peter Wolf

Journal: Seizure. 2017 Jul;49():36-41.

 

In consequence of newer research juvenile myoclonic epilepsy (JME) is no longer seen as a homogeneous disease. The causes of the existing variance are only partially known yet. We discuss to what extent the phenotypical spectrum of this polygenetically determined disorder expresses ...

Last Updated: 31 Dec 1969

Go To URL
Juvenile myoclonic epilepsy: Challenges on its 60th anniversary.
 

Author(s): Elza Márcia Yacubian

Journal: Seizure. 2017 Jan;44():48-52.

 

Since its initial 1957 description, juvenile myoclonic epilepsy (JME) has been recognized as a common epileptic syndrome worldwide.

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Biology of Juvenile Myoclonic Epilepsy
 

Status: Recruiting

Condition Summary: Juvenile Myoclonic Epilepsy

 

Last Updated: 12 Jan 2018

Go to URL