Ketosis

Common Name(s)

Ketosis

Ketosis, or hyperketonuria, is a condition where the body produces excess ketones (a type of organic compound). This can happen if the body does not have enough insulin, so it can be connected to diabetes. When the body doesn’t have enough carbohydrates or glycogen stored in the liver to use for energy, it converts fat to energy. Normally the body is able to balance the amount of fat it uses for energy. However, during periods where the body experiences prolonged fasting, starvation, or problems with insulin, the body may begin turning some of the parts of fat (long chain fatty acids) into ketones in the liver. The reason the body does this is because the brain cells cannot use long chain fatty acids for energy, but they can use ketones. Unfortunately, if the problem persists, the amount of ketones in the bloodstream may raise too high. The body expels these ketones in the urine, increasing the amount in an affected person’s urine.

Factors which may increase the risk of ketosis include exercising for long periods of time, severely restricting calorie or carbohydrate intake, uncontrolled diabetes, and exercising for long periods of time. Sometimes ketosis occurs during pregnancy. There are usually no noticeable symptoms other than increased ketones in the urine

Sometimes, ketosis may cause dehydration and, in some cases, may change the chemical makeup of blood. It may also lead to ketoacidosis, which is a similar but dangerous condition where affected individuals have high levels of glucose in addition to high ketone levels. Urine tests can be used to evaluate the ketone levels in the urine. It is important to determine the cause so that the ketosis can be treated. Talk to your doctor about the most current treatment options.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ketosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ketosis" returned 87 free, full-text research articles on human participants. First 3 results:

Ketone Body Acetoacetate Buffers Methylglyoxal via a Non-enzymatic Conversion during Diabetic and Dietary Ketosis.
 

Author(s): Trine Salomón, Christian Sibbersen, Jakob Hansen, Dieter Britz, Mads Vandsted Svart, Thomas Schmidt Voss, Niels Møller, Niels Gregersen, Karl Anker Jørgensen, Johan Palmfeldt, Thomas Bjørnskov Poulsen, Mogens Johannsen

Journal: Cell Chem Biol. 2017 Aug;24(8):935-943.e7.

 

The α-oxoaldehyde methylglyoxal is a ubiquitous and highly reactive metabolite known to be involved in aging- and diabetes-related diseases. If not detoxified by the endogenous glyoxalase system, it exerts its detrimental effects primarily by reacting with biopolymers such as DNA ...

Last Updated: 31 Dec 1969

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[Euglycemic ketosis in an adolescent with type 1 diabetes on insulin and dapaglifozin: Case report].
 

Author(s): Marcia Pereyra A, Cristhian Ramírez, Rossana Román

Journal: Rev Chil Pediatr. 2017 Jun;88(3):404-410.

 

Dapagliflozin, an insulin-independent sodium-glucose cotransporter 2 inhibitor (SGLT2-I) induces glycosuria and reduces hyperglycemia in adults with type 2 diabetes.

Last Updated: 31 Dec 1969

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HbA as a Screening tool for Ketosis in Patients with Type 2 Diabetes Mellitus.
 

Author(s): Bing Zhu, Le Bu, Manna Zhang, Aaron M Gusdon, Liang Zheng, Sharvan Rampersad, Jue Li, Shen Qu

Journal:

 

Ketosis in patients with type 2 diabetes mellitus (T2DM) is overlooked due to atypical symptoms. The objective of this study is to evaluate the value of hemoglobin A (HbA) as a screening tool for ketosis in T2DM patients. This retrospective study consisted of 253 T2DM patients with ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ketosis" returned 5 free, full-text review articles on human participants. First 3 results:

[Ketosis-prone type 2 diabetes can be expected to increase in Sweden].
 

Author(s): Åke Sjöholm, Malin Pettersson, Camilla Botold, Jan Saaf

Journal:

 

Last Updated: 31 Dec 1969

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Hyperketonemia and ketosis increase the risk of complications in type 1 diabetes.
 

Author(s): Preeti Kanikarla-Marie, Sushil K Jain

Journal: Free Radic. Biol. Med.. 2016 06;95():268-77.

 

Diets that boost ketone production are increasingly used for treating several neurological disorders. Elevation in ketones in most cases is considered favorable, as they provide energy and are efficient in fueling the body's energy needs. Despite all the benefits from ketones, the ...

Last Updated: 31 Dec 1969

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Ketosis and brain handling of glutamate, glutamine, and GABA.
 

Author(s): Marc Yudkoff, Yevgeny Daikhin, Oksana Horyn, Ilana Nissim, Itzhak Nissim

Journal: Epilepsia. 2008 Nov;49 Suppl 8():73-5.

 

We hypothesize that one mechanism of the anti-epileptic effect of the ketogenic diet is to alter brain handling of glutamate. According to this formulation, in ketotic brain astrocyte metabolism is more active, resulting in enhanced conversion of glutamate to glutamine. This allows ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Does a Ketogenic Diet Causes Ketosis in Patients on Intensive Care?
 

Status: Not yet recruiting

Condition Summary: Ketosis

 

Last Updated: 8 Nov 2016

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Study of Arginine and Nitric Oxide in Patients With Diabetes
 

Status: Not yet recruiting

Condition Summary: Ketosis Prone Diabetes

 

Last Updated: 12 Jun 2018

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Two Bag System for Diabetic Ketoacidosis
 

Status: Recruiting

Condition Summary: Diabetic Ketoacidosis

 

Last Updated: 10 Oct 2018

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