Lambert Eaton myasthenic syndrome

Common Name(s)

Lambert Eaton myasthenic syndrome, Lambert-Eaton Syndrome

Lambert Eaton myasthenic syndrome (LEMS) is a disorder of the neuromuscular junction. The neuromuscular junction is the site where nerve cells meet muscle cells and help activate the muscles. This syndrome occurs when antibodies interfere with electrical impulses between the nerve and muscle cells. It may be associated with other autoimmune diseases, or more commonly coincide with or precede a diagnosis of cancer such as small cell lung cancer. Symptoms may include muscle weakness, a tingling sensation in the affected areas, fatigue, and dry mouth. Treatment of a underlying disorder or cancer is the first priority of treatment.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lambert Eaton myasthenic syndrome" for support, advocacy or research.

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Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

Last Updated: 15 Jul 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lambert Eaton myasthenic syndrome" for support, advocacy or research.

Logo
Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

http://www.mdausa.org

Last Updated: 15 Jul 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lambert Eaton myasthenic syndrome" returned 55 free, full-text research articles on human participants. First 3 results:

Coexistence of myasthenia gravis and Lambert-Eaton myasthenic syndrome in a small cell lung cancer patient: A case report.
 

Author(s): Rui Jia, Jinbo Chen, Ruli Ge, Qi Zheng, Fang Chen, Zhonghua Zhao

Journal: Medicine (Baltimore). 2018 Jun;97(23):e10976.

 

Myasthenia gravis (MG) and Lambert-Eaton myasthenic syndrome (LEMS) are both neuromuscular junction diseases, and some controversy exists whether the 2 diseases occur at the same time.

Last Updated: 31 Dec 1969

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Coexistence of Lambert-Eaton myasthenic syndrome and autoimmune encephalitis with anti-CRMP5/CV2 and anti-GABAB receptor antibodies in small cell lung cancer: A case report.
 

Author(s): Hongfang Li, Aimei Zhang, Yanlei Hao, Hongzhi Guan, Zhanyun Lv

Journal: Medicine (Baltimore). 2018 May;97(19):e0696.

 

Autoimmune encephalitis and Lambert-Eaton myasthenic syndrome are classic paraneoplastic neurological conditions common in patients with small cell lung cancer.

Last Updated: 31 Dec 1969

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Paraneoplastic Cerebellar Degeneration and Lambert-Eaton Myasthenic Syndrome Associated with Neuroendocrine Carcinoma of the Oropharynx.
 

Author(s): Junji Takasugi, Munehisa Shimamura, Toru Koda, Toshihiro Kishikawa, Atsushi Hanamoto, Hidenori Inohara, Kazuaki Sato, Eiichi Morii, Masakatsu Motomura, Manabu Sakaguchi, Yuji Nakatsuji, Hideki Mochizuki

Journal: Intern. Med.. 2018 Feb;57(4):587-590.

 

Paraneoplastic cerebellar degeneration and Lambert-Eaton myasthenic syndrome (PCD-LEMS) are usually associated with small-cell lung carcinoma (SCLC). PCD-LEMS with extrapulmonary non-SCLC tumors; however, has not been previously reported. A 78-year-old man presented with dysarthria, ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lambert Eaton myasthenic syndrome" returned 3 free, full-text review articles on human participants. First 3 results:

Synaptic Pathophysiology and Treatment of Lambert-Eaton Myasthenic Syndrome.
 

Author(s): Tyler B Tarr, Peter Wipf, Stephen D Meriney

Journal: Mol. Neurobiol.. 2015 Aug;52(1):456-63.

 

Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease that disrupts the normally reliable neurotransmission at the neuromuscular junction (NMJ). This disruption is thought to result from an autoantibody-mediated removal of a subset of the P/Q-type Ca(2+) channels involved ...

Last Updated: 31 Dec 1969

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Lambert-Eaton myasthenic syndrome.
 

Author(s): U Seneviratne, R de Silva

Journal: Postgrad Med J. 1999 Sep;75(887):516-20.

 

The Lambert-Eaton myasthenic syndrome is a neuromuscular disorder characterised by defective neurotransmitter release at autonomic neurones and presynaptic terminals of the neuromuscular junction. It is caused by an IgG autoantibody formed against especially the P/Q type of voltage-gated ...

Last Updated: 31 Dec 1969

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An autoimmune channelopathy associated with cancer: Lambert-Eaton myasthenic syndrome.
 

Author(s): M Takamori

Journal: Intern. Med.. 1999 Feb;38(2):86-96.

 

The Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease that is often associated with lung cancer which shares a common antigenic protein with the motor nerve terminal. The myasthenic weakness is caused by an antibody-induced reduction in the release of acetylcholine ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Treatment of Lambert-Eaton Syndrome With 3,4 Diaminopyridine
 

Status: Available

Condition Summary: Lambert-Eaton Myasthenic Syndrome

 

Last Updated: 3 Nov 2017

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Treatment of Lambert-Eaton Syndrome With 3,4 DAP
 

Status: Available

Condition Summary: Lambert Eaton Myasthenic Syndrome

 

Last Updated: 16 May 2018

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Use of 3,4-Diaminopyridine in the Treatment of Lambert-Eaton Syndrome
 

Status: Available

Condition Summary: Lambert Eaton Myasthenic Syndrome

 

Last Updated: 8 May 2018

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