Langerhans cell histiocytosis

Common Name(s)

Langerhans cell histiocytosis, Eosinophilic Granuloma, Hand-Schuller-Christian disease

Langerhans cell histiocytosis (LCH) is a disorder that primarily affects children, but is also found in adults of all ages. People with LCH produce too many Langerhans cells or histiocytes, a form of white blood cell found in healthy people that is supposed to protect the body from infection. In people with LCH, these cells multiply excessively and build up in certain areas of the body, causing tumors called granulomas to form. The symptoms vary among affected individuals, and the cause of LCH is unknown. In most cases, this condition is not life-threatening. Some people do experience life-long problems associated with LCH.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Langerhans cell histiocytosis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Langerhans cell histiocytosis" returned 335 free, full-text research articles on human participants. First 3 results:

The application of x-ray, computed tomography, and magnetic resonance imaging on 22 pediatric Langerhans cell histiocytosis patients with long bone involvement: A retrospective analysis.
 

Author(s): Xiaojun Zhang, Jing Zhou, Xuee Chai, Guiling Chen, Bin Guo, Lei Ni, Peng Wu

Journal: Medicine (Baltimore). 2018 Apr;97(17):e0411.

 

The studies focusing on x-ray, computed tomography (CT), and magnetic resonance imaging (MRI) in pediatric Langerhans cell histiocytosis (LCH) patients were still rare. Therefore, we aimed to evaluate the application of x-ray, CT, and MRI in pediatric LCH patients with long bone involvement.Total ...

Last Updated: 31 Dec 1969

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Congenital Langerhans cell histiocytosis: a good prognosis disease?
 

Author(s): Ana Paula Frade, Mariana Marteleto Godinho, Anna Beatriz Willemes Batalha, Ana Paula Silva Bueno

Journal: An Bras Dermatol. 2017 ;92(5 Suppl 1):40-42.

 

Langerhans cell histiocytosis is rare and more frequent in children. The skin is affected in 50% of the cases and is the only site in 10%. Its course varies from self-limited and localized forms to severe multisystemic forms. Congenital cases are usually exclusively cutaneous and ...

Last Updated: 31 Dec 1969

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Pulmonary Langerhans cell histiocytosis in a 26-year-old female: still a diagnostic challenge.
 

Author(s): Edith Simona Ianoşi, Mihaela Mureşan, Simona Gurzu, Eugenia Corina Budin, Ioan Jung, Tivadar Bara, Gabriela Jimborean

Journal: Rom J Morphol Embryol. 2017 ;58(3):1047-1050.

 

Langerhans cell histiocytosis (LCH) is a rare disorder caused by monoclonal Langerhans cells proliferation in bone, skin, lung, lymph nodes, liver, spleen, nervous or hematopoietic system. Pulmonary LCH is a diagnostic trap that is displayed on computed tomography (CT) as an interstitial ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Langerhans cell histiocytosis" returned 51 free, full-text review articles on human participants. First 3 results:

Successful management of multiple-systemic Langerhans cell histiocytosis involving endocrine organs in an adult: A case report and review of literature.
 

Author(s): Junhui Xie, Zhen Li, Yi Tang

Journal: Medicine (Baltimore). 2018 Jun;97(26):e11215.

 

Langerhans cell histiocytosis (LCH) involving non-endocrine organs has been frequently reported, whereas LCH involving endocrine organs is rare and the mechanism is unclear.

Last Updated: 31 Dec 1969

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How I manage pulmonary Langerhans cell histiocytosis.
 

Author(s): Gwenaël Lorillon, Abdellatif Tazi

Journal:

 

Pulmonary Langerhans cell histiocytosis (PLCH) is a rare sporadic cystic lung disease of unknown aetiology that is characterised by the infiltration and destruction of the wall of distal bronchioles by CD1a Langerhans-like cells. In adults, PLCH is frequently isolated and affects ...

Last Updated: 31 Dec 1969

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Langerhans cell histiocytosis of the thyroid complicated by papillary thyroid carcinoma: A case report and brief literature review.
 

Author(s): Xin Wu, Shi Chen, Li-Yang Zhang, Ya-Ping Luo, Ying Jiang, Rui-E Feng

Journal: Medicine (Baltimore). 2017 Sep;96(35):e7954.

 

Langerhans cell histiocytosis (LCH) involves mainly the skin and bone and rarely the thyroid. Meanwhile, papillary thyroid carcinoma (PTC) is the most common subtype of thyroid cancer. Both LCH and PTC could make the thyroid enlarged and hypermetabolic. The coincidence of these 2 ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 2 Aug 2018

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Last Updated: 2 May 2018

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Vinblastine/Prednisone Versus Single Therapy With Cytarabine for Langerhans Cell Histiocytosis (LCH)
 

Status: Recruiting

Condition Summary: Langerhans Cell Histiocytosis

 

Last Updated: 15 Nov 2017

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