Langerhans cell sarcoma

Common Name(s)

Langerhans cell sarcoma

Langerhans cell sarcoma is a form of cancer characterized by abnormal growth of Langerhans cell found in the lymph nodes, which are small gland-like organs that are part of the body's immune system. Since lymph nodes are situated in many parts of the body, abnormal cell growth can lead to problems occuring in many organs, such as the liver, lungs and the spleen. Hence, individuals may experience digestive as well as immune system problems. Individuals may be more prone to being ill and have trouble recovering from them. Treatment depends on the severity of the cancer. Doctors may suggest patients undergo surgery to remove the abnormal cell growth. If the cancer has progressed, doctors may also suggest chemotherapy or radiotherapy

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Condition Specific Organizations

Following organizations serve the condition "Langerhans cell sarcoma" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Langerhans cell sarcoma" returned 12 free, full-text research articles on human participants. First 3 results:

Cytological findings of langerhans cell sarcoma in a case of quintuple cancer.
 

Author(s): Satomi Tabata, Masaki Murata, Akira Takasawa, Atsushi Fukuda, Jun Ogasawara, Takayuki Koseki, Katsuhiko Nakano, Keiko Segawa, Rena Morita, Tadashi Hasegawa, Norimasa Sawada

Journal: Diagn. Cytopathol.. 2017 May;45(5):441-445.

 

Langerhans cell sarcoma (LCS) and quintuple cancers are extremely rare. In this report, a case of quintuple cancers including LCS was described. An 80-year-old man had squamous cell carcinoma of the nasal skin, colon and rectum adenocarcinomas, and T-cell/histiocyte-rich large B-cell ...

Last Updated: 31 Dec 1969

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Langerhans cell sarcoma arising from the root of tongue: a rare case.
 

Author(s): Jian-Jun Ren, Yu Zhao, Ming-Juan Liu, Guo Liu, Fei Chen

Journal:

 

Langerhans cell sarcoma (LCS), a rare malignant disease with markedly malignant cytological features and poor outcome, originates from Langerhans cells and most commonly affects the lymph nodes, skin, and bone. This paper presents the case of a 58-year-old female with LCS at the root ...

Last Updated: 31 Dec 1969

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Dramatic transient improvement of metastatic BRAF(V600E)-mutated Langerhans cell sarcoma under treatment with dabrafenib.
 

Author(s): Samia Mourah, Gwenaël Lorillon, Véronique Meignin, Laetitia Vercellino, Constance de Margerie-Mellon, Cécile Pages, Lauriane Goldwirt, Alexandre How-Kit, Jorg Tost, Céleste Lebbe, Abdellatif Tazi

Journal: Blood. 2015 Dec;126(24):2649-52.

 

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Langerhans cell sarcoma" returned 3 free, full-text review articles on human participants. First 3 results:

Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma: Current Understanding and Differential Diagnosis.
 

Author(s): Hirokazu Nakamine, Mitsunori Yamakawa, Tadashi Yoshino, Takaya Fukumoto, Yasunori Enomoto, Itaru Matsumura

Journal: J Clin Exp Hematop. 2016 ;56(2):109-118.

 

Langerhans cell (LC) histiocytosis (LCH) and LC sarcoma (LCS) are proliferative processes consisting of cells having morphologic and phenotypic features of Langerhans cells (LCs), although the latter may have lost some of these features. Because neoplastic nature of LCH as well as ...

Last Updated: 31 Dec 1969

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Langerhans cell sarcoma: a case report and review of the literature.
 

Author(s): D T Liu, J Friesenbichler, L A Holzer, B Liegl-Atzwanger, C Beham-Schmid, A Leithner

Journal: Pol J Pathol. 2016 Jun;67(2):172-8.

 

We present the case of a 62-year-old male patient with a three-month history of pain in the left shoulder. Magnetic resonance imaging of the left scapula showed an osteo-destructive lesion. H and E stained sections revealed a Langerhans cell sarcoma, and immunohistochemistry was performed ...

Last Updated: 31 Dec 1969

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Multifocal Langerhans cell sarcoma involving epidermis: a case report and review.
 

Author(s): Changsong Wang, Yanping Chen, Chunfang Gao, Jian Yin, Hong Li

Journal:

 

To study the clinico-pathological characteristics of Langerhans cell sarcoma (LCS) which involving epidermis.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study of Lenalidomide for Adult Histiocyte Disorders
 

Status: Recruiting

Condition Summary: Langerhans Cell Histiocytosis (LCH); Histiocytoses Erdheim-chester Disease; Histiocytic Sarcoma (HS)

 

Last Updated: 31 May 2017

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Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)
 

Status: Recruiting

Condition Summary: Advanced Malignant Solid Neoplasm; Ann Arbor Stage III Childhood Non-Hodgkin Lymphoma; Ann Arbor Stage IV Childhood Non-Hodgkin Lymphoma; Childhood Langerhans Cell Histiocytosis; Histiocytic Sarcoma; Juvenile Xanthogranuloma; Malignant Glioma; Recurrent Central Nervous System Neoplasm; Recurrent Childhood Ependymoma; Recurrent Childhood Malignant Germ Cell Tumor; Recurrent Childhood Medulloblastoma; Recurrent Childhood Non-Hodgkin Lymphoma; Recurrent Childhood Rhabdomyosarcoma; Recurrent Childhood Soft Tissue Sarcoma; Recurrent Ewing Sarcoma; Recurrent Glioma; Recurrent Hepatoblastoma; Recurrent Langerhans Cell Histiocytosis; Recurrent Malignant Solid Neoplasm; Recurrent Neuroblastoma; Recurrent Osteosarcoma; Recurrent Peripheral Primitive Neuroectodermal Tumor; Refractory Central Nervous System Neoplasm; Refractory Childhood Malignant Germ Cell Tumor; Refractory Langerhans Cell Histiocytosis; Refractory Malignant Solid Neoplasm; Refractory Neuroblastoma; Rhabdoid Tumor; Stage III Osteosarcoma AJCC v7; Stage III Soft Tissue Sarcoma AJCC v7; Stage IV Osteosarcoma AJCC v7; Stage IV Soft Tissue Sarcoma AJCC v7; Stage IVA Osteosarcoma AJCC v7; Stage IVB Osteosarcoma AJCC v7; Wilms Tumor

 

Last Updated: 18 May 2018

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Palbociclib in Treating Patients With Relapsed or Refractory Rb Positive Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating Alterations in Cell Cycle Genes (A Pediatric MATCH Treatment Trial)
 

Status: Not yet recruiting

Condition Summary: Advanced Malignant Solid Neoplasm; RB1 Positive; Recurrent Childhood Ependymoma; Recurrent Ewing Sarcoma; Recurrent Glioma; Recurrent Hepatoblastoma; Recurrent Kidney Wilms Tumor; Recurrent Langerhans Cell Histiocytosis; Recurrent Malignant Germ Cell Tumor; Recurrent Malignant Glioma; Recurrent Medulloblastoma; Recurrent Neuroblastoma; Recurrent Non-Hodgkin Lymphoma; Recurrent Osteosarcoma; Recurrent Peripheral Primitive Neuroectodermal Tumor; Recurrent Rhabdoid Tumor; Recurrent Rhabdomyosarcoma; Recurrent Soft Tissue Sarcoma; Refractory Ependymoma; Refractory Ewing Sarcoma; Refractory Glioma; Refractory Hepatoblastoma; Refractory Langerhans Cell Histiocytosis; Refractory Malignant Germ Cell Tumor; Refractory Malignant Glioma; Refractory Medulloblastoma; Refractory Neuroblastoma; Refractory Non-Hodgkin Lymphoma; Refractory Osteosarcoma; Refractory Peripheral Primitive Neuroectodermal Tumor; Refractory Rhabdoid Tumor; Refractory Rhabdomyosarcoma; Refractory Soft Tissue Sarcoma

 

Last Updated: 15 May 2018

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