Large B cell diffuse lymphoma

Common Name(s)

Large B cell diffuse lymphoma

Large B cell diffuse lymphoma is a rare form of immune system cancer characterized by abnormal development and overproduction of B cells, a type of white blood cell. B cells are essential to the immune system because they produce antibodies that are responsible for recognizing foreign material and signalling the body to attack them. Individuals with this disorder may experience symptoms such as enlarged lymph nodes, fatigue, night sweats, and higher frequency of illness. Doctors often diagnose this form of cancer early, since symptoms are apparent. Treatment depends on the stage of the cancer. If the cancer has progressed, doctors may suggest patients undergo chemotherapy or radiotherapy to destroy cancerous B cells.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Large B cell diffuse lymphoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Large B cell diffuse lymphoma" returned 1326 free, full-text research articles on human participants. First 3 results:

Identification of relevant drugable targets in diffuse large B-cell lymphoma using a genome-wide unbiased CD20 guilt-by association approach.
 

Author(s): Mathilde R W de Jong, Lydia Visser, Gerwin Huls, Arjan Diepstra, Marcel van Vugt, Emanuele Ammatuna, Rozemarijn S van Rijn, Edo Vellenga, Anke van den Berg, Rudolf S N Fehrmann, Tom van Meerten

Journal:

 

Forty percent of patients with diffuse large B-cell lymphoma (DLBCL) show resistant disease to standard chemotherapy (CHOP) in combination with the anti-CD20 monoclonal antibody rituximab (R). Although many new anti-cancer drugs were developed in the last years, it is unclear which ...

Last Updated: 31 Dec 1969

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[Rectal diffuse large B cell lymphoma appearing after immunosuppression for ulcerative colitis. Report of one case].
 

Author(s): Rodrigo Quera, Lilian Flores, Daniela Simian, Udo Kronberg, María Teresa Vial, David Ladrón de Guevara, María José García-Rodríguez

Journal: Rev Med Chil. 2017 Oct;145(10):1342-1348.

 

Primary colorectal lymphoma is a rare form of presentation of gastrointestinal tract lymphomas. Inflammatory bowel disease and its treatment are risk factors for its development. We report a 47-year-old male patient with Ulcerative Colitis of two years of evolution, treated initially ...

Last Updated: 31 Dec 1969

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Sequential occurrence of diffuse large B-cell lymphoma and carcinoma in the nasopharynx: A case report.
 

Author(s): Yong Tae Hong, Ki Hwan Hong

Journal: Medicine (Baltimore). 2018 Jan;97(2):e9595.

 

The sequential occurrence of the 2 malignancies development of nasopharyngeal carcinoma (NPC) and lymphoma is extremely rare and their coexistence raises the question of a common etiologic factor.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Large B cell diffuse lymphoma" returned 104 free, full-text review articles on human participants. First 3 results:

Isolated skeletal muscle recurrence of an originally nodal diffuse large B cell lymphoma: A case report and review of the literature.
 

Author(s): Nikolaos Spetsieris, Nefeli Giannakopoulou, Eleni Variami, Konstantinos Zervakis, Niki Rougala, Georgios Garefalakis, Vasiliki Skarlatou, Nora-Athina Viniou, Panagiotis Diamantopoulos

Journal: Medicine (Baltimore). 2018 Jan;97(3):e9608.

 

Diffuse large B cell lymphoma (DLBCL) is a malignancy of the B cells with extranodal primary involvement being estimated at 30% to 40% of cases. Primary skeletal muscle presentation of DLBCL is extremely rare, with an estimated incidence of about 0.5% of extranodal lymphomas, presenting ...

Last Updated: 31 Dec 1969

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CT and PET/CT findings of primary pulmonary diffuse large B-cell lymphoma: One case report and literature review.
 

Author(s): Yanjun Bai, Wenjie Liang

Journal: Medicine (Baltimore). 2017 Nov;96(47):e8876.

 

Primary pulmonary diffuse large B-cell lymphoma (PPL-DLBCL) is rare and its clinical manifestations lack specificity. In this report, we present one case of PPL-DLBCL with complete clinical and imaging data, including uncontrast-enhanced CT, contrast-enhanced CT, and positron emission ...

Last Updated: 31 Dec 1969

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Diffuse large B-cell lymphoma: can genomics improve treatment options for a curable cancer?
 

Author(s): Amit Dipak Amin, Tara L Peters, Lingxiao Li, Soumya Sundara Rajan, Ramesh Choudhari, Soham D Puvvada, Jonathan H Schatz

Journal: Cold Spring Harb Mol Case Stud. 2017 May;3(3):a001719.

 

Gene-expression profiling and next-generation sequencing have defined diffuse large B-cell lymphoma (DLBCL), the most common lymphoma diagnosis, as a heterogeneous group of subentities. Despite ongoing explosions of data illuminating disparate pathogenic mechanisms, however, the five-drug ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Oral Azacitidine Plus Salvage Chemotherapy in Relapsed/Refractory Diffuse Large B Cell Lymphoma
 

Status: Not yet recruiting

Condition Summary: Large B-Cell Diffuse Lymphoma

 

Last Updated: 27 Feb 2018

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Idelalisib Post Allogeneic Hematopoietic Stem Cell Transplant (HSCT) in B Cell Derived Malignancies: A Phase 1 Double Blinded Randomized Placebo Toxicity Trial"
 

Status: Not yet recruiting

Condition Summary: B Cells-Tumors; B Cell Chronic Lymphocytic Leukemia; Follicular Lymphoma; Mantle Cell Lymphoma; Large B-Cell Diffuse Lymphoma of Bone (Diagnosis)

 

Last Updated: 16 Apr 2018

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