Late acute graft versus host disease

Common Name(s)

Late acute graft versus host disease, GRAFT-VERSUS-HOST DISEASE, SUSCEPTIBILITY TO

Transplantation of hematopoietic stem cells is a successful therapy for some tumors derived from bone marrow precursors, such as certain leukemias and lymphomas, and it can be used to cure some primary immunodeficiencies and inherited hematopoietic stem-cell diseases. One of the major complications of allogeneic bone marrow transplantation is graft-versus-host disease (GVHD), in which mature donor T cells that contaminate the allogeneic bone marrow recognize the tissues of the recipient as foreign, causing a severe inflammatory disease characterized by rashes, diarrhea, and liver disease. GVHD is particularly virulent when there is a mismatch of a major major histocompatibility complex (MHC) class I or class II antigen. Most transplants are therefore undertaken only when the donor and recipient are HLA-matched sibs or, less frequently, when there is an HLA-matched unrelated donor. However, GVHD also occurs in the context of disparities between minor histocompatibility antigens, and immunosuppression must be used in every stem-cell transplant (summary by {3:Janeway et al., 2005}). At the core of the immunogenetic basis for GVHD is the diversity of HLA, killer immunoglobulin-like receptors (KIRs; see {604936}), and cytokine genes. HLA class I molecules function as ligands for natural killer cell inhibitory KIRs, indicating that GVHD results from a complex interplay between innate and adaptive immune responses. Cytokines may modulate the intensity of tissue injury and inflammation in GVHD, and therefore cytokine polymorphisms in either patient or donor or both may explain individual risks of GVHD (review by {5:Petersdorf and Malkki, 2006}).
 

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Condition Specific Organizations

Following organizations serve the condition "Late acute graft versus host disease" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Late acute graft versus host disease" returned 3 free, full-text research articles on human participants. First 3 results:

Late acute graft-versus-host disease: a prospective analysis of clinical outcomes and circulating angiogenic factors.
 

Author(s): Shernan G Holtan, Nandita Khera, John E Levine, Xiaoyu Chai, Barry Storer, Hien D Liu, Yoshihiro Inamoto, George L Chen, Sebastian Mayer, Mukta Arora, Jeanne Palmer, Mary E D Flowers, Corey S Cutler, Alexander Lukez, Sally Arai, Aleksandr Lazaryan, Laura F Newell, Christa Krupski, Madan H Jagasia, Iskra Pusic, William Wood, Anne S Renteria, Gregory Yanik, William J Hogan, Elizabeth Hexner, Francis Ayuk, Ernst Holler, Phandee Watanaboonyongcharoen, Yvonne A Efebera, James L M Ferrara, Angela Panoskaltsis-Mortari, Daniel Weisdorf, Stephanie J Lee, Joseph Pidala

Journal: Blood. 2016 11;128(19):2350-2358.

 

Late acute (LA) graft-versus-host disease (GVHD) is persistent, recurrent, or new-onset acute GVHD symptoms occurring >100 days after allogeneic hematopoietic cell transplantation (HCT). The aim of this analysis is to describe the onset, course, morbidity, and mortality of and examine ...

Last Updated: 31 Dec 1969

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Late Acute Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation.
 

Author(s): Aazim K Omer, Daniel J Weisdorf, Aleksandr Lazaryan, Ryan Shanley, Bruce R Blazar, Margaret L MacMillan, Claudio Brunstein, Nelli Bejanyan, Mukta Arora

Journal: Biol. Blood Marrow Transplant.. 2016 May;22(5):879-83.

 

There are little data regarding the incidence, clinical manifestations, risk factors, and outcomes of late acute graft-versus-host disease (aGVHD). We evaluated patients with late aGVHD after allogeneic hematopoietic cell transplantation (HCT) between 2007 and 2012 and compared their ...

Last Updated: 31 Dec 1969

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Late Acute and Chronic Graft-versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation.
 

Author(s): Mukta Arora, Corey S Cutler, Madan H Jagasia, Joseph Pidala, Xiaoyu Chai, Paul J Martin, Mary E D Flowers, Yoshihiro Inamoto, George L Chen, William A Wood, Nandita Khera, Jeanne Palmer, Hien Duong, Sally Arai, Sebastian Mayer, Iskra Pusic, Stephanie J Lee

Journal: Biol. Blood Marrow Transplant.. 2016 Mar;22(3):449-55.

 

Several distinct graft-versus-host disease (GVHD)-related syndromes have been defined by the National Institutes of Health Consensus Conference. We enrolled a prospective cohort of 911 hematopoietic cell transplantation (HCT) recipients at 13 centers between March 2011 and May 2014 ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Late acute graft versus host disease" returned 1 free, full-text review articles on human participants. First 3 results:

Hosting an Unruly Guest: The Impact of Late Acute and Chronic Graft-versus-Host Disease.
 

Author(s): Michael Byrne, Bipin N Savani

Journal: Biol. Blood Marrow Transplant.. 2016 May;22(5):779-80.

 

Last Updated: 31 Dec 1969

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