Late-onset retinal degeneration

Common Name(s)

Late-onset retinal degeneration

Late-onset retinal degeneration (LORD) is an autosomal dominant disorder characterized by onset in the fifth to sixth decade with night blindness and punctate yellow-white deposits in the retinal fundus, progressing to severe central and peripheral degeneration, with choroidal neovascularization and chorioretinal atrophy ({1:Hayward et al., 2003}).
 

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Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Late-onset retinal degeneration" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Late-onset retinal degeneration" returned 8 free, full-text research articles on human participants. First 3 results:

LONGITUDINAL STRUCTURAL CHANGES IN LATE-ONSET RETINAL DEGENERATION.
 

Author(s): Catherine Cukras, Jason Flamendorf, Wai T Wong, Radha Ayyagari, Denise Cunningham, Paul A Sieving

Journal: Retina (Philadelphia, Pa.). 2016 Dec;36(12):2348-2356.

 

To characterize longitudinal structural changes in early stages of late-onset retinal degeneration to investigate pathogenic mechanisms.

Last Updated: 31 Dec 1969

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Last Updated: 31 Dec 1969

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Presence of rd8 mutation does not alter the ocular phenotype of late-onset retinal degeneration mouse model.
 

Author(s): Bhubanananda Sahu, Venkata R M Chavali, Akhila Alapati, John Suk, Dirk-Uwe Bartsch, Monica M Jablonski, Radha Ayyagari

Journal:

 

A spontaneous frameshift mutation, c.3481delC, in the Crb1 gene is the underlying cause of dysplasia and retinal degeneration in rd8 mice. The rd8 mutation is found in C57BL/6N but not in C57BL/6J mouse sub-strains. The development of ocular pathology in single knockout Ccl2-/-, Cx3cr1-/- ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Late-onset retinal degeneration" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Self-confidence Study in Patients With Argus II Artificial Retina
 

Status: Recruiting

Condition Summary: Pigmentary Retinopathy

 

Last Updated: 4 Jul 2018

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Cell Collection to Study Eye Diseases
 

Status: Recruiting

Condition Summary: Retinal Disease; AMD; Retinal Degeneration

 

Last Updated: 22 Sep 2018

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