Madelung's disease

Common Name(s)

Madelung's disease, Multiple symmetric lipomatosis, Launois-Bensaude adenolipomatosis, Familial symmetric lipomatosis

Madelung disease is a rare condition characterized by the symmetric growth of fatty tumors (lipomas) around the neck, shoulders, upper arms and/or upper trunk. It most often affects men of Mediterranean ancestry between the ages of 30 and 70 who have a history of alcohol abuse. Non-alcoholics and women can also be affected. The signs and symptoms vary greatly from person to person. Usually, accumulation of fatty tissue increases over time and may lead to a loss of neck mobility and pain. The lipomas can cause physical deformity and peripheral neuropathy. In the majority of cases, the disease is benign; however, lipomas can become cancerous in rare circumstances. The exact cause of Madelung disease is unknown, but it may be associated with changes (mutations) in mitochondrial DNA and/or alcoholism. Treatment may include medications to correct associated metabolic conditions; surgery or liposuction to remove the lipomas; and avoidance of alcohol.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Madelung's disease" for support, advocacy or research.

Fat Disorders Research Society

FDRS is dedicated to improving the quality of life for all people affected by adipose tissue disorders such as lipedema, lipoedema, Dercum's Disease, Madelung's Disease and Familial Multiple Lipomatosis, through research, education, advocacy and collaboration.

Last Updated: 9 Mar 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Madelung's disease" for support, advocacy or research.

Fat Disorders Research Society

FDRS is dedicated to improving the quality of life for all people affected by adipose tissue disorders such as lipedema, lipoedema, Dercum's Disease, Madelung's Disease and Familial Multiple Lipomatosis, through research, education, advocacy and collaboration.

http://www.fatdisorders.org

Last Updated: 9 Mar 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Madelung's disease" returned 19 free, full-text research articles on human participants. First 3 results:

Madelung's disease: A benign symmetric lipomatosis.
 

Author(s): Prasenjeet Mohanty, K Vivekanandh, Gaurav Dash, Liza Mohapatra

Journal: Indian J Dermatol Venereol Leprol. ;84(2):190-191.

 

Last Updated: 31 Dec 1969

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Bilateral breast enlargement in a chronic alcoholic: do not miss Madelung's disease.
 

Author(s): Sayantan Ray, Partha Pratim Chakraborty, Subhodip Pramanik, Subhankar Chowdhury

Journal:

 

Last Updated: 31 Dec 1969

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IMAGES IN CLINICAL MEDICINE. Madelung's Disease.
 

Author(s): Giuseppe Nisi, Andrea Sisti

Journal: N. Engl. J. Med.. 2016 Feb;374(6):572.

 

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Madelung's disease" returned 3 free, full-text review articles on human participants. First 3 results:

Application of lateral tarsoconjunctival flap to correct ocular complications of Madelung's disease: A case report and literature review.
 

Author(s): Lung-Chi Lee, Tsu-Heng Weng, Ke-Hao Huang, Hsin-Ting Lin, Chang-Min Liang, Ming-Cheng Tai, Jiann-Torng Chen, Ke-Hung Chien

Journal: Medicine (Baltimore). 2018 Oct;97(42):e12864.

 

Madelung's disease is a specific type of benign symmetric lipomatosis, which is characterized by overgrowing fat distributed at the neck and shoulder. This excessive fat accumulation may occur in different regions, including vital organs, such as the larynx, trachea, or the orbits. ...

Last Updated: 31 Dec 1969

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Madelung's Disease: Lipectomy or Liposuction?
 

Author(s): Chun-Ye Chen, Qing-Qing Fang, Xiao-Feng Wang, Min-Xia Zhang, Wan-Yi Zhao, Bang-Hui Shi, Li-Hong Wu, Li-Yun Zhang, Wei-Qiang Tan

Journal:

 

Madelung's disease is a rare lipid metabolic disorder characterized by diffuse, uncapsulated lipomas in the neck, shoulder, and other areas. It mainly affects middle-aged men and is related to alcohol abuse, and the cause is not clear. Surgical treatments include lipectomy and liposuction.

Last Updated: 31 Dec 1969

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Madelung's disease as a rare cause of obstructive sleep apnea.
 

Author(s): Vitor Alexandre Oliveira Fonseca, Carlos Alves, Helena Marques, Elvira Camacho, António Pinto Saraiva

Journal: J Bras Pneumol. 2009 Oct;35(10):1053-6.

 

Madelung's disease, or multiple symmetric lipomatosis, is a rare disease, characterized by accumulation of unencapsulated fat, generally located symmetrically around the neck and shoulders. Here, we present the case of a patient with diffuse lipomatosis accompanied by obstructive ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Insight Into Subcutaneous Adipose Tissue Disorders
 

Status: Recruiting

Condition Summary: Lipedema; Dercum's Disease; Familial Multiple Lipomatosis; Madelung's Disease

 

Last Updated: 14 Sep 2017

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Evaluation of Safety and Efficacy of RZL-012 for the Treatment of Lipedema or of Nodular Dercum's Disease
 

Status: Recruiting

Condition Summary: Lipedema; Dercum Disease

 

Last Updated: 6 May 2018

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Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer
 

Status: Recruiting

Condition Summary: Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Acute Leukemia in Remission; Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia; Acute Myeloid Leukemia With FLT3/ITD Mutation; Acute Myeloid Leukemia With Gene Mutations; Aplastic Anemia; B-Cell Non-Hodgkin Lymphoma; CD40 Ligand Deficiency; Chronic Granulomatous Disease; Chronic Leukemia in Remission; Chronic Lymphocytic Leukemia; Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Chronic Myelomonocytic Leukemia; Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Congenital Amegakaryocytic Thrombocytopenia; Congenital Neutropenia; Congenital Pure Red Cell Aplasia; Glanzmann Thrombasthenia; Immunodeficiency Syndrome; Myelodysplastic Syndrome; Myelofibrosis; Myeloproliferative Neoplasm; Paroxysmal Nocturnal Hemoglobinuria; Plasma Cell Myeloma; Polycythemia Vera; Recurrent Non-Hodgkin Lymphoma; Refractory Non-Hodgkin Lymphoma; Secondary Acute Myeloid Leukemia; Secondary Myelodysplastic Syndrome; Severe Aplastic Anemia; Shwachman-Diamond Syndrome; Sickle Cell Disease; T-Cell Non-Hodgkin Lymphoma; Thalassemia; Waldenstrom Macroglobulinemia; Wiskott-Aldrich Syndrome

 

Last Updated: 13 Jun 2018

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