Amblyopia

Common Name(s)

Amblyopia, Lazy eye

Ambylopia, commonly known as lazy eye, is abnormal visual development in infancy and early childhood. It is the leading cause of decreased vision in children and usually develops because of abnormalities in the fibers (nerves) between the brain and the eye. The brain tends to focus on the eye that has good vision and ignore the weak (lazy) eye, causing it to wander. If left untreated, lazy eye can result in mild or even complete vision loss. Symptoms of lazy eye can include a tendency to bump into objects, a wandering eye, eyes that do not work together, poor depth perception, and double vision. Lazy eye usually affects only one eye, but it is possible for both to be affected.

There are three common causes of lazy eye: strabismus, deprivation and refraction. Strabismus means the muscles in each eye are not equal, causing the eyes to cross in or turn out. Deprivation occurs if there is a problem with one eye, such as a cloudy lens (cataract), which does not allow normal vision. Refraction occurs when there is a significant difference between the vision in each eye, such as nearsightedness or farsightedness. Risk factors include a family history of lazy eye, premature birth, or low birth weight.

Your doctor can diagnose lazy eye with eye examinations that are usually part of routine medical care. If your physician has concern for lazy eye, they can refer to an eye specialist, such as an ophthalmologist or an optometrist, to determine the reason for your child’s lazy eye. Treatments can include corrective eyewear (glasses or contacts), eye patch, and eye drops. If the lazy eye is severe enough, surgery may be needed to correct the issue. Proper treatment usually improves vision within weeks or months. Typically, the earlier treatment is started, the better the outcome. If your child has been diagnosed with lazy eye, talk with your doctor about the best treatment plan.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Amblyopia" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Amblyopia" returned 508 free, full-text research articles on human participants. First 3 results:

Effect of optical correction on subfoveal choroidal thickness in children with anisohypermetropic amblyopia.
 

Author(s): Tomo Nishi, Tetsuo Ueda, Yuutaro Mizusawa, Kentaro Semba, Kayo Shinomiya, Yoshinori Mitamura, Taiji Sakamoto, Nahoko Ogata

Journal:

 

The purpose of this study was to determine the effect of optical correction on the best-corrected visual acuity (BCVA) and subfoveal choroidal thickness (CT) in the eyes of children with anisohypermetropic amblyopia. Twenty-four anisohypermetropic amblyopic eyes and their fellow eyes ...

Last Updated: 31 Dec 1969

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Cognitive processing of orientation discrimination in anisometropic amblyopia.
 

Author(s): Jianglan Wang, Jiao Zhao, Shoujing Wang, Rui Gong, Zhong Zheng, Longqian Liu

Journal:

 

Cognition is very important in our daily life. However, amblyopia has abnormal visual cognition. Physiological changes of the brain during processes of cognition could be reflected with ERPs. So the purpose of this study was to investigate the speed and the capacity of resource allocation ...

Last Updated: 31 Dec 1969

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Macular retinal and choroidal thickness in unilateral amblyopia using swept-source optical coherence tomography.
 

Author(s): Syunsuke Araki, Atsushi Miki, Katsutoshi Goto, Tsutomu Yamashita, Go Takizawa, Kazuko Haruishi, Yoshiaki Ieki, Junichi Kiryu, Kiyoshi Yaoeda

Journal:

 

To investigate macular retinal and choroidal thickness in amblyopic eyes compared to that in fellow and normal eyes using swept-source optical coherence tomography (SS-OCT).

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Amblyopia" returned 42 free, full-text review articles on human participants. First 3 results:

The Davida Teller Award Lecture, 2016: Visual Brain Development: A review of "Dorsal Stream Vulnerability"-motion, mathematics, amblyopia, actions, and attention.
 

Author(s): Janette Atkinson

Journal: J Vis. 2017 Mar;17(3):26.

 

Research in the Visual Development Unit on "dorsal stream vulnerability' (DSV) arose from research in two somewhat different areas. In the first, using cortical milestones for local and global processing from our neurobiological model, we identified cerebral visual impairment in infants ...

Last Updated: 31 Dec 1969

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Amblyopia: neural basis and therapeutic approaches.
 

Author(s): Caio César Peixoto Bretas, Renato Nery Soriano

Journal: Arq Bras Oftalmol. ;79(5):346-351.

 

Abnormalities in visual processing caused by visual deprivation or abnormal binocular interaction may induce amblyopia, which is characterized by reduced visual acuity. Occlusion therapy, the conventional treatment, requires special attention as occlusion of the fellow normal eye ...

Last Updated: 31 Dec 1969

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The challenges of amblyopia treatment.
 

Author(s): Gail D E Maconachie, Irene Gottlob

Journal: Biomed J. 2015 Dec;38(6):510-6.

 

The treatment of amblyopia, particularly anisometropic (difference in refractive correction) and/or strabismic (turn of one eye) amblyopia has long been a challenge for many clinicians. Achieving optimum outcomes, where the amblyopic eye reaches a visual acuity similar to the fellow ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Binocular Dig Rush Game Treatment for Amblyopia
 

Status: Recruiting

Condition Summary: Amblyopia

 

Last Updated: 27 Oct 2017

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Binocular Amblyopia Treatment
 

Status: Recruiting

Condition Summary: Amblyopia

 

Last Updated: 18 Sep 2017

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Treatment of Residual Amblyopia With Donepezil
 

Status: Recruiting

Condition Summary: Amblyopia

 

Last Updated: 7 Feb 2017

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