Legionnaires' disease

Common Name(s)

Legionnaires' disease

Legionnaires' disease is a severe form of pneumonia (lung inflammation usually caused by infection). Legionnaires’ disease is caused by a bacterium known as legionella. Most people get Legionnaires’ disease from inhaling the bacteria. People who smoke, are older than 50, or have a weakened immune system are at higher risk of developing Legionnaires’ disease. The legionella bacterium also causes Pontiac fever, a milder illness resembling the flu.

Symptoms may include headache, muscle pain, chills, fever, cough, shortness of breath, chest pain, gastrointestinal symptoms, and confusion or other mental changes. Complications can be serious and life threatening including respiratory failure, septic shock, and acute kidney failure. To diagnosis Legionnaires’ disease and the presence of legionella bacteria, your doctor may use a blood test, chest X-ray, sample of you lung tissue or a CT scan. Legionnaires’ disease is treated with antibiotics and in some cases may require hospitalization. If you or a family member has been diagnosed with Legionnaires’ disease, talk with your doctor about the most current treatment options.

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Condition Specific Organizations

Following organizations serve the condition "Legionnaires' disease" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Legionnaires' disease" returned 254 free, full-text research articles on human participants. First 3 results:

The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans.
 

Author(s): Juan S Ruiz-Moreno, Lutz Hamann, Javeed A Shah, Annelies Verbon, Frank P Mockenhaupt, Monika Puzianowska-Kuznicka, Jan Naujoks, Leif E Sander, Martin Witzenrath, John C Cambier, Norbert Suttorp, Ralf R Schumann, Lei Jin, Thomas R Hawn, Bastian Opitz,

Journal:

 

The cyclic GMP-AMP synthase (cGAS)-STING pathway is central for innate immune sensing of various bacterial, viral and protozoal infections. Recent studies identified the common HAQ and R232H alleles of TMEM173/STING, but the functional consequences of these variants for primary infections ...

Last Updated: 31 Dec 1969

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Legionnaires' Disease Outbreaks and Cooling Towers, New York City, New York, USA.
 

Author(s): Robert Fitzhenry, Don Weiss, Dan Cimini, Sharon Balter, Christopher Boyd, Lisa Alleyne, Renee Stewart, Natasha McIntosh, Andrea Econome, Ying Lin, Inessa Rubinstein, Teresa Passaretti, Anna Kidney, Pascal Lapierre, Daniel Kass, Jay K Varma

Journal: Emerging Infect. Dis.. 2017 11;23(11):.

 

The incidence of Legionnaires' disease in the United States has been increasing since 2000. Outbreaks and clusters are associated with decorative, recreational, domestic, and industrial water systems, with the largest outbreaks being caused by cooling towers. Since 2006, 6 community-associated ...

Last Updated: 31 Dec 1969

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Weather-Dependent Risk for Legionnaires' Disease, United States.
 

Author(s): Jacob E Simmering, Linnea A Polgreen, Douglas B Hornick, Daniel K Sewell, Philip M Polgreen

Journal: Emerging Infect. Dis.. 2017 11;23(11):1843-1851.

 

Using the Nationwide Inpatient Sample and US weather data, we estimated the probability of community-acquired pneumonia (CAP) being diagnosed as Legionnaires' disease (LD). LD risk increases when weather is warm and humid. With warm weather, we found a dose-response relationship between ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Legionnaires' disease" returned 6 free, full-text review articles on human participants. First 3 results:

Diagnostic testing for Legionnaires' disease.
 

Author(s): David M Pierre, Julianne Baron, Victor L Yu, Janet E Stout

Journal:

 

Legionnaires' disease is commonly diagnosed clinically using a urinary antigen test. The urinary antigen test is highly accurate for L. pneumophila serogroup 1, however other diagnostic tests should also be utilized in conjunction with the urinary antigen as many other Legionella ...

Last Updated: 31 Dec 1969

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Legionnaires' Disease in Hotels and Passenger Ships: A Systematic Review of Evidence, Sources, and Contributing Factors.
 

Author(s): Varvara A Mouchtouri, James W Rudge

Journal: J Travel Med. ;22(5):325-37.

 

Travel-associated Legionnaires' disease (LD) is a serious problem, and hundreds of cases are reported every year among travelers who stayed at hotels, despite the efforts of international and governmental authorities and hotel operators to prevent additional cases.

Last Updated: 31 Dec 1969

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[Legionella, Legionnaires' disease].
 

Author(s): Yvan Jamilloux, Sophie Jarraud, Gérard Lina, Jérôme Etienne, Florence Ader

Journal: Med Sci (Paris). ;28(6-7):639-45.

 

Legionella is the causative agent of Legionnaires' disease, a severe form of pneumonia. Detection of Legionella pneumophila serogroup 1 antigen in urine samples has shortened the delay of diagnosis and subsequent treatment initiation resulting in decreased mortality. Improved surveillance ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Legionnaires' Effect on Smell
 

Status: Recruiting

Condition Summary: Legionnaires' Disease

 

Last Updated: 31 Jul 2018

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Bacterial and Human Biomarkers of Prognostic Value for Severe Legionnaire's Disease
 

Status: Not yet recruiting

Condition Summary: Legionella

 

Last Updated: 17 Aug 2017

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Impact of Legionella Urine Antigen Testing (LUAT) on the Local Epidemiology and Diagnosis of Legionella Pneumonia
 

Status: Not yet recruiting

Condition Summary: Legionella Pneumophila Pneumonia

 

Last Updated: 26 Jun 2017

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