Leprosy

Common Name(s)

Leprosy

Leprosy is a disease caused by the bacterium Mycobacterium leprae. Due to its long incubation period, it is difficult to know where or when someone has caught the disease, though children are more likely than adults to contract it. Leprosy is common in many countries, especially in temperate, tropical, and subtropical climates. Symptoms of leprosy include skin lesions, muscle weakness, and numbness. It is not highly infectious, but is transmitted through droplets from close contact with infected persons. Although leprosy is curable and treatment is available, if left untreated, leprosy can cause progressive and permanent damage to the skin, nerves, limbs, and eyes.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Leprosy" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Leprosy" returned 1625 free, full-text research articles on human participants. First 3 results:

Whole blood profiling of leprosy type 1(reversal) reactions highlights prominence of innate immune response genes.
 

Author(s): Jamile Leão Rêgo, Nadja de Lima Santana, Paulo Roberto Lima Machado, Marcelo Ribeiro-Alves, Thiago Gomes de Toledo-Pinto, Léa Cristina Castellucci, Milton Ozório Moraes

Journal:

 

The major factors contributing for nerve damage and permanent disabilities in leprosy are type 1 or reversal reactions (RR) and type 2 or erythema nodosum leprosum (ENL). Gene profiling of leprosy reactions have shown that different pathways are activated during the course of reactions, ...

Last Updated: 31 Dec 1969

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Borderline tuberculoid leprosy mimicking sarcoidosis: A case report.
 

Author(s): Jian Liu, Yan Wen, Yan Xing, Shuo Wang

Journal: Medicine (Baltimore). 2018 Aug;97(32):e11616.

 

Leprosy is a chronic infectious granulomas disease caused by Mycobacterium leprae that can manifest as a wide variety of immunological and clinical features.

Last Updated: 31 Dec 1969

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Diagnosis and impact of neuropathic pain in leprosy patients in Nepal after completion of multidrug therapy.
 

Author(s): Han-Siong Toh, Jeni Maharjan, Ruby Thapa, Kapil Dev Neupane, Mahesh Shah, Suwash Baral, Deanna A Hagge, Indra Bahadur Napit, Diana N J Lockwood

Journal:

 

Neuropathic pain (NP) can occur as a chronic complication of leprosy neuropathy. NP epidemiology and its impact on patients have not been well documented. This study investigates NP prevalence and impact in the years after patients are declared "released from treatment" (RFT) following ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Leprosy" returned 115 free, full-text review articles on human participants. First 3 results:

Socioeconomic risk markers of leprosy in high-burden countries: A systematic review and meta-analysis.
 

Author(s): Julia Moreira Pescarini, Agostino Strina, Joilda Silva Nery, Lacita Menezes Skalinski, Kaio Vinicius Freitas de Andrade, Maria Lucia F Penna, Elizabeth B Brickley, Laura C Rodrigues, Mauricio Lima Barreto, Gerson Oliveira Penna

Journal:

 

Over 200,000 new cases of leprosy are detected each year, of which approximately 7% are associated with grade-2 disabilities (G2Ds). For achieving leprosy elimination, one of the main challenges will be targeting higher risk groups within endemic communities. Nevertheless, the socioeconomic ...

Last Updated: 31 Dec 1969

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A rare case of type 1 leprosy reactions following tetanus infection in a borderline tuberculoid leprosy patient and a literature review.
 

Author(s): Chao Shi, Zhi-Chun Jing, De-Gang Yang, Jian-Yu Zhu

Journal:

 

Type 1 leprosy reaction, also known as "reversal reaction", is related to cellular immune responses to Mycobacterium leprae antigens. The risk factors that trigger type 1 leprosy reactions are poorly understood. Leprosy with concurrent tetanus is rare, and there are no publicly available ...

Last Updated: 31 Dec 1969

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Elimination of leprosy in India: An analysis.
 

Author(s): Utpal Sengupta

Journal: Indian J Dermatol Venereol Leprol. 2018 ;84(2):131-136.

 

India attained the elimination figure of less than 1 case of leprosy per 10,000 people during December 2005. Despite this, India still accounts for the largest number of new leprosy cases in the world, maintaining more than 50 per cent of the leprosy burden of the world, notwithstanding ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Low Level Laser Therapy Effects in Peripheral Nerves Patient With Leprosy.
 

Status: Recruiting

Condition Summary: Leprosy Neuropathy

 

Last Updated: 1 Mar 2017

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Post ExpOsure Prophylaxis for LEprosy in the Comoros and Madagascar
 

Status: Not yet recruiting

Condition Summary: Leprosy

 

Last Updated: 5 Sep 2018

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Last Updated: 15 May 2018

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