Leukoplakia

Common Name(s)

Leukoplakia

Leukoplakia is a condition in which thickened, white patches form on the tongue, gums, inside of the cheek, or sometimes on the outer female genitals. Although the sores can vary in appearance, they are usually white or gray; thick; and slightly raised with a hard surface. The condition is thought to be caused by irritation, but the cause is not always known. Tobacco is considered to be the main cause of its development in the mouth. Most patches are benign, but a small percentage show early signs of cancer. Removing the source of irritation may cause the condition to go away, but surgery to remove the sore(s) may be necessary in some cases.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Leukoplakia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Leukoplakia" returned 209 free, full-text research articles on human participants. First 3 results:

Determination and diagnostic value of CA9 mRNA in peripheral blood of patients with oral leukoplakia.
 

Author(s): Manuel Torres López, Mario Pérez Sayáns, Cintia Chamorro Petronacci, Francisco Barros Angueira, Pilar Gándara Vila, Alejandro Lorenzo Pouso, Abel García García

Journal: J Enzyme Inhib Med Chem. 2018 Dec;33(1):951-955.

 

Oral leukoplakia is one of the most common oral premalignant disorder. The classical evaluation through tissue biopsy is not always valid to evaluate the risk of malignization.

Last Updated: 31 Dec 1969

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Evaluation of Collagen in Leukoplakia, Oral Submucous Fibrosis and Oral Squamous Cell Carcinomas Using Polarizing Microscopy and Immunohistochemistry
 

Author(s): Krishna Singh Arora, Amit Nayyar, Prabhpreet Kaur, Karandeep Singh Arora, Ankur Goel, Simarjeev Singh

Journal:

 

Objectives: Picrosirius red and MMP are capable of degrading extracellular matrix proteins, expressed in lesions such as squamous cell carcinomas. The present study was undertaken with an aim to analyze and compare changes in collagen using Picrosirius red staining under polarizing ...

Last Updated: 31 Dec 1969

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Expression and oncogenic properties of membranous Notch1 in oral leukoplakia and oral squamous cell carcinoma.
 

Author(s): Xu Ding, Yang Zheng, Zhao Wang, Wei Zhang, Yibo Dong, Wantao Chen, Jiang Li, Weiming Chu, Wei Zhang, Yi Zhong, Li Mao, Xiaomeng Song, Yunong Wu

Journal: Oncol. Rep.. 2018 Jun;39(6):2584-2594.

 

Notch1 signaling is essential for tissue development and tumor progression. This signaling pathway has also been implicated in oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC). However, the role of Notch1 expression in OL and its malignant transformation is unknown. This ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Leukoplakia" returned 13 free, full-text review articles on human participants. First 3 results:

A plea to provide best evidence in trials under sample-size restrictions: the example of pioglitazone to resolve leukoplakia and erythroplakia in Fanconi anemia patients.
 

Author(s): Florian Lasch, Kristina Weber, Mwe Mwe Chao, Armin Koch

Journal:

 

In planning a clinical trial for demonstrating the efficacy of pioglitazone to resolve leukoplakia and erythroplakia in Fanconi anemia patients we had to discuss the need for a randomized controlled trial particularly under sample-size restrictions as very promising results were available ...

Last Updated: 31 Dec 1969

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Proliferative verrucous leukoplakia: diagnosis, management and current advances.
 

Author(s): Diogo Lenzi Capella, Jussara Maria Gonçalves, Adelino António Artur Abrantes, Liliane Janete Grando, Filipe Ivan Daniel

Journal: Braz J Otorhinolaryngol. ;83(5):585-593.

 

Proliferative verrucous leukoplakia is a multifocal and progressive lesion of the oral mucosa, with unknown etiology, and commonly resistant to all therapy attempts with frequent recurrences. It is characterized by a high rate of oral squamous cell carcinoma and verrucou carcinoma transformations.

Last Updated: 31 Dec 1969

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Interventions for treating oral leukoplakia to prevent oral cancer.
 

Author(s): Giovanni Lodi, Roberto Franchini, Saman Warnakulasuriya, Elena Maria Varoni, Andrea Sardella, Alexander R Kerr, Antonio Carrassi, L C I MacDonald, Helen V Worthington

Journal:

 

Oral leukoplakia is a relatively common oral lesion that, in a small proportion of people, precedes the development of oral cancer. Most leukoplakias are asymptomatic; therefore, the primary objective of treatment should be to prevent onset of cancer. This review updates our previous ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Safety and Efficacy of Nivolumab in Treating Oral Proliferative Verrucous Leukoplakia
 

Status: Not yet recruiting

Condition Summary: Leukoplakia, Oral

 

Last Updated: 1 Oct 2018

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Pembrolizumab in Treating Participants With Leukoplakia
 

Status: Not yet recruiting

Condition Summary: Erythroleukoplakia; Leukoplakia; Verrucous Oral Leukoplakia

 

Last Updated: 18 Jul 2018

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Diagnostic Accuracy of Salivary DNA Integrity Index in Oral Malignant and Premalignant Lesions
 

Status: Not yet recruiting

Condition Summary: Oral Cancer; Oral Lichen Planus; Oral Leukoplakia

 

Last Updated: 21 Sep 2018

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