Localized scleroderma

Common Name(s)

Localized scleroderma

Localized scleroderma is characterized by thickening of the skin from excessive collagen deposits. Collagen is a protein normally present in our skin that provides structural support. However, when too much collagen is made, the skin becomes stiff and hard. Localized types of scleroderma are those limited to the skin and related tissues and, in some cases, the muscle below. Internal organs are not affected by localized scleroderma, and localized scleroderma can never progress to the systemic form of the disease. Often, localized conditions improve or go away on their own over time, but the skin changes and damage that occur when the disease is active can be permanent. For some people, localized scleroderma is serious and disabling.

There are two generally recognized types of localized scleroderma: morphea and linear.

 

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Localized scleroderma" for support, advocacy or research.

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Raynaud's & Scleroderma Ireland

• To improve the lives of patients, their families and carers by providing support, advice and information. • To increase the awareness of Raynaud’s and Scleroderma amongst healthcare professionals, Government and Statutory agencies and the general public. • To work in partnership with appropriate healthcare professionals and agencies to promote and co-ordinate the attainment of the objectives of the strategy. • Maintain a working environment that fosters communication, teamwork and diversity among all members of staff- permanent, temporary and voluntary

Last Updated: 6 May 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Localized scleroderma" for support, advocacy or research.

Logo
Raynaud's & Scleroderma Ireland

• To improve the lives of patients, their families and carers by providing support, advice and information. • To increase the awareness of Raynaud’s and Scleroderma amongst healthcare professionals, Government and Statutory agencies and the general public. • To work in partnership with appropriate healthcare professionals and agencies to promote and co-ordinate the attainment of the objectives of the strategy. • Maintain a working environment that fosters communication, teamwork and diversity among all members of staff- permanent, temporary and voluntary

http://www.irishraynauds.com

Last Updated: 6 May 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Localized scleroderma" returned 59 free, full-text research articles on human participants. First 3 results:

Reliability of LoSCAT score for activity and tissue damage assessment in a large cohort of patients with Juvenile Localized Scleroderma.
 

Author(s): Anna Agazzi, Gloria Fadanelli, Fabio Vittadello, Francesco Zulian, Giorgia Martini

Journal:

 

To assess reliability of the two indexes of Localized Scleroderma Cutaneous Assessment Tool (LoSCAT), the modified Localized Scleroderma Skin Severity Index (mLoSSI) and the Localized Scleroderma Skin Damage Index (LoSDI), when applied by clinicians with different experience in scoring ...

Last Updated: 31 Dec 1969

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[Localized scleroderma: about 24 cases].
 

Author(s): Sara Elloudi, Hanane Baybay, Salim Gallouj, Fatima Zohra Mernissi

Journal:

 

Morphea, also known as localized scleroderma, is defined as a sclerosus skin condition that can extend to the subcutaneous tissue but with no Raynaud's phenomenon or visceral involvement. Some clinical forms may have a functional and aesthetic impact, hence the interest of treatment ...

Last Updated: 31 Dec 1969

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Detection of autoimmune antibodies in localized scleroderma by synthetic oligonucleotide antigens.
 

Author(s): Simone Samuelsen, Christian Damsgaard Jørgensen, Elizabeth D Mellins, Kathryn S Torok, Kira Astakhova

Journal:

 

In this study, we developed a series of synthetic oligonucleotides that allowed us to investigate the details on the antigen recognition by autoimmune antibodies in localized scleroderma subjects. Besides dramatically improved analytical specificity of the assay, our data suggests ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Localized scleroderma" returned 7 free, full-text review articles on human participants. First 3 results:

Localized scleroderma presenting as port-wine stains: report of two cases and a literature review.
 

Author(s): Hiroyuki Kanoh, En Shu, Yoshiro Ichiki, Mariko Seishima

Journal: Acta Derm. Venereol.. 2015 Nov;95(8):1003-4.

 

Last Updated: 31 Dec 1969

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Localized scleroderma: clinical spectrum and therapeutic update.
 

Author(s): Mariana Figueiroa Careta, Ricardo Romiti

Journal: An Bras Dermatol. ;90(1):62-73.

 

Scleroderma is a rare connective tissue disease that is manifested by cutaneous sclerosis and variable systemic involvement. Two categories of scleroderma are known: systemic sclerosis, characterized by cutaneous sclerosis and visceral involvement, and localized scleroderma or morphea ...

Last Updated: 31 Dec 1969

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Pediatric scleroderma: systemic or localized forms.
 

Author(s): Kathryn S Torok

Journal: Pediatr. Clin. North Am.. 2012 Apr;59(2):381-405.

 

Pediatric scleroderma includes 2 major groups of clinical entities, systemic sclerosis (SSc) and localized scleroderma (LS). Although both share a common pathophysiology, their clinical manifestations differ. LS is typically confined to the skin and underlying subcutis, with up to ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pilot Study Evaluating the Efficacy of a Topical PDE4 Inhibitor for Morphea
 

Status: Recruiting

Condition Summary: Morphea

 

Last Updated: 11 Sep 2018

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Study to Assess Sarilumab in Halting Progression of Morphea
 

Status: Not yet recruiting

Condition Summary: Morphea, Plaque Form

 

Last Updated: 18 Sep 2018

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Morphea in Adults and Children (MAC) Cohort Study: A Morphea Registry and DNA Repository
 

Status: Recruiting

Condition Summary: Scleroderma, Localized; Morphea; Frontal Linear Scleroderma en Coup de Sabre; Scleroderma, Circumscribed; Scleroderma, Linear

 

Last Updated: 2 Dec 2014

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