Locked-in syndrome

Common Name(s)

Locked-in syndrome

Locked-in syndrome is a rare neurological disorder. Signs and symptoms include paralysis of voluntary muscles in the body, except for those that control eye movement.Individuals with locked-in syndrome are conscious and can think and reason, but are unable to speak or move.  It may be caused by brain stem stroke, traumatic brain injury, diseases of the circulatory system, diseases that destroy the myelin sheath surrounding nerve cells, or medication overdose.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Locked-in syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Locked-in syndrome" returned 45 free, full-text research articles on human participants. First 3 results:

Reverse Locked-In Syndrome.
 

Author(s): Pooja Raibagkar, Ram V Chavali, Tamara B Kaplan, Jennifer A Kim, Meaghan V Nitka, Sherry H-Y Chou, Brian L Edlow

Journal: Neurocrit Care. 2017 Aug;27(1):108-114.

 

Basilar artery occlusion can cause locked-in syndrome, which is characterized by quadriplegia, anarthria, and limited communication via eye movements. Here, we describe an uncommon stroke syndrome associated with endovascular recanalization of the top of the basilar artery: "reverse ...

Last Updated: 31 Dec 1969

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Fluctuating locked-in syndrome as a presentation of a bilateral pontine infarction.
 

Author(s): Carlos García-Esperón, Elena López-Cancio, Lorena Martín-Aguilar, Mónica Millán, Carlos Castaño, Josep Munuera, Antoni Dávalos

Journal: Neuroradiol J. 2016 Oct;29(5):347-9.

 

The "pontine warning syndrome" is characterized by recurrent episodes of motor hemiparesis, dysarthria and horizontal gaze palsy associated with basilar artery branch infarction. We report a case of a patient who presented with recurrent, self-limited episodes of locked-in syndrome, ...

Last Updated: 31 Dec 1969

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Evaluation of the visual function of patients with locked-in syndrome: Report of 13 cases.
 

Author(s): M Graber, G Challe, M F Alexandre, B Bodaghi, P LeHoang, V Touitou

Journal: J Fr Ophtalmol. 2016 May;39(5):437-40.

 

Although visual function is thought to be preserved in patients with locked-in syndrome (LIS), enabling them to communicate through vertical or lateral eye movements or blinking of the upper eyelid, nothing is known about the actual visual function of patients with LIS. The goal of ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Locked-in syndrome" returned 6 free, full-text review articles on human participants. First 3 results:

Effect of Exercise on Physical Recovery of People with Locked-In Syndrome after Stroke: What Do We Know from the Current Evidence? A Systematic Review.
 

Author(s): Ying Man Law, Lan Fang Feng, Qui Liang, Li Jiao Meng, Peng Shen, Shuai Jiang Yu, Wing Yi Pao

Journal: Cerebrovasc Dis Extra. 2018 ;8(2):90-95.

 

Locked-in syndrome (LIS) results from a brainstem lesion in the pons. Ischemic stroke is the most common etiology of LIS. People with LIS have poor mobility with serious complications due to immobilization. Benefits of exercise after stroke have been widely reported. However, little ...

Last Updated: 31 Dec 1969

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Life can be worth living in locked-in syndrome.
 

Author(s): D Lulé, C Zickler, S Häcker, M A Bruno, A Demertzi, F Pellas, S Laureys, A Kübler

Journal: Prog. Brain Res.. 2009 ;177():339-51.

 

The locked-in syndrome (LIS) describes patients who are awake and conscious but severely deefferented leaving the patient in a state of almost complete immobility and loss of verbal communication. The etiology ranges from acute (e.g., brainstem stroke, which is the most frequent cause ...

Last Updated: 31 Dec 1969

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[Life with Locked-In syndrome].
 

Author(s): M A Bruno, F Pellas, J L Bernheim, D Ledoux, S Goldman, A Demertzi, S Majerus, A Vanhaudenhuyse, V Blandin, M Boly, P Boveroux, G Moonen, S Laureys, C Schnakers

Journal: Rev Med Liege. ;63(5-6):445-51.

 

The Locked-In Syndrome (LIS) is classically caused by an anterior pontine vascular lesion and characterized by quadriplegia and anarthria with preserved consciousness and intellectual functioning. We here review the definition, etiologies, diagnosis and prognosis of LIS patients and ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Feasibility of mindBEAGLE in Disorders of Consciousness or Locked-In Syndrome
 

Status: Recruiting

Condition Summary: Consciousness Disorders; Locked-In Syndrome

 

Last Updated: 26 Mar 2018

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Brain Computer Interface Complete locked-in State Communication
 

Status: Recruiting

Condition Summary: Complete Locked-in State

 

Last Updated: 29 Nov 2016

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First Study With a Brain Implant to Help Locked-in Patients Communicate at Home
 

Status: Recruiting

Condition Summary: Locked-In Syndrome

 

Last Updated: 18 Dec 2017

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