Logopenic progressive aphasia

Common Name(s)

Logopenic progressive aphasia

Logopenic progressive aphasia (LPA) is a type of dementia characterized by language disturbance, including difficulty making or understanding speech (aphasia). It is a type of primary progressive aphasia (PPA). Affected individuals have slow, hesitant speech due to difficulty retrieving the correct words, names, or numbers. Speech is typically well articulated and grammatically correct with good single-word comprehension. But over time, affected individuals may have trouble understanding long or complex verbal information, due to problems holding onto lengthy information that they hear. Language difficulties associated with LPA are due to shrinking, or atrophy, in the left posterior temporal cortex and inferior parietal lobule. Click here to view an image of the lobes of the brain. AlzheimerÕs disease is the most common cause. There is a high frequency of apolipoprotein E4 genotype in LPA.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Logopenic progressive aphasia" for support, advocacy or research.

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Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

Last Updated: 8 Jul 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Logopenic progressive aphasia" for support, advocacy or research.

Logo
Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

http://www.theaftd.org

Last Updated: 8 Jul 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Logopenic progressive aphasia" returned 25 free, full-text research articles on human participants. First 3 results:

Clinical marker for Alzheimer disease pathology in logopenic primary progressive aphasia.
 

Author(s): Lucia A A Giannini, David J Irwin, Corey T McMillan, Sharon Ash, Katya Rascovsky, David A Wolk, Vivianna M Van Deerlin, Edward B Lee, John Q Trojanowski, Murray Grossman

Journal: Neurology. 2017 Jun;88(24):2276-2284.

 

To determine whether logopenic features of phonologic loop dysfunction reflect Alzheimer disease (AD) neuropathology in primary progressive aphasia (PPA).

Last Updated: 31 Dec 1969

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F-FDG PET/CT and functional MRI in a case of crossed logopenic primary progressive aphasia.
 

Author(s): M N Cabrera-Martín, J A Matías-Guiu, M Yus-Fuertes, M Valles-Salgado, T Moreno-Ramos, J Matías-Guiu, J L Carreras Delgado

Journal: Rev Esp Med Nucl Imagen Mol. ;35(6):394-397.

 

Primary progressive aphasia is a clinical syndrome caused by a neurodegeneration of areas and neural networks involved in language, usually in the left hemisphere. The term "crossed aphasia" denotes an acquired language dysfunction caused by a lesion in the hemisphere ipsilateral ...

Last Updated: 31 Dec 1969

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Varying Degrees of Temporoparietal Hypometabolism on FDG-PET Reveal Amyloid-Positive Logopenic Primary Progressive Aphasia is not a Homogeneous Clinical Entity.
 

Author(s): Kamini Krishnan, Mary M Machulda, Jennifer L Whitwell, Alissa M Butts, Joseph R Duffy, Edythe A Strand, Matthew L Senjem, Anthony J Spychalla, Clifford R Jack, Val J Lowe, Keith A Josephs

Journal: J. Alzheimers Dis.. 2017 ;55(3):1019-1029.

 

The logopenic variant of primary progressive aphasia (lvPPA) manifests due to a breakdown of the language network with prominent hypometabolism of the left temporoparietal region. LvPPA is strongly associated with amyloid deposition, yet there is question as to whether it is a homogeneous ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Logopenic progressive aphasia" returned 2 free, full-text review articles on human participants. First 3 results:

The logopenic variant of primary progressive aphasia.
 

Author(s): Maya L Henry, Maria Luisa Gorno-Tempini

Journal: Curr. Opin. Neurol.. 2010 Dec;23(6):633-7.

 

The aim is to explore the evolution of the logopenic variant of primary progressive aphasia as a distinct clinical entity and to outline recent advances that have clarified its clinical characteristics, neural underpinnings, and potential genetic and pathological bases. This is particularly ...

Last Updated: 31 Dec 1969

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The new classification of primary progressive aphasia into semantic, logopenic, or nonfluent/agrammatic variants.
 

Author(s): Michael F Bonner, Sharon Ash, Murray Grossman

Journal: Curr Neurol Neurosci Rep. 2010 Nov;10(6):484-90.

 

Primary progressive aphasia (PPA), typically resulting from a neurodegenerative disease such as frontotemporal lobar degeneration or Alzheimer's disease, is characterized by a progressive loss of specific language functions with relative sparing of other cognitive domains. Three variants ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Molecular and Structural Imaging in Atypical Alzheimer's Disease: A Longitudinal Study
 

Status: Recruiting

Condition Summary: Atypical Alzheimer's Disease; Logopenic Progressive Aphasia (LPA); Posterior Cortical Atrophy (PCA)

 

Last Updated: 23 Mar 2018

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Early-onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural Networks
 

Status: Recruiting

Condition Summary: Alzheimer Disease, Early Onset; Alzheimer Disease; Alzheimer Disease, Late Onset; Dementia, Alzheimer Type; Logopenic Progressive Aphasia; Primary Progressive Aphasia; Visuospatial/Perceptual Abilities; Posterior Cortical Atrophy; Executive Dysfunction; Corticobasal Degeneration; Ideomotor Apraxia

 

Last Updated: 15 Oct 2018

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rTMS as a Treatment for PPA
 

Status: Not yet recruiting

Condition Summary: Logopenic Variant Primary Progressive Aphasia; Non-Fluent Primary Progressive Aphasia

 

Last Updated: 15 Jan 2018

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