Diffuse astrocytoma

Common Name(s)

Diffuse astrocytoma, Astrocytoma type II, Low-grade astrocytoma

Diffuse astrocytoma, also known as astrocytoma type II, is characterized by slow growing tumors in the brain. Diffuse means that they can spread into the surrounding regions of the brain. They can be found in any part of the brain; however, they are most commonly found in the cerebral hemispheres or the "thinking" parts of the brain.

Diffuse astrocytomas are part of a larger group of tumors called gliomas because they arise from specialized glial tissue of the brain. Astrocytomas particularly arise from the supportive tissue cells of the brain called astrocytes. There are four types of astrocytomas ranging from I-IV and are defined by tumor growth speed and the way in which it spreads. Diffuse astrocytomas are type II.

Symptoms of diffuse astrocytoma include headaches, seizures, memory loss, and changes in behavior. It can be diagnosed via MRI or CT scanning and then may be biopsied to determine the grade of the tumor. Treatment options depend on the type, size, and location of the tumor, if and how far it has spread, as well as the patient’s overall health. For diffuse astrocytoma, if the tumor is accessible and can be removed, then only additional follow-up scans are needed. Radiation may also be used as a supplemental treatment to surgery. Diffuse astrocytomas are typically seen in young adults but can also be diagnosed in children and seniors. If you or a loved one has been diagnosed with diffuse astrocytoma, talk to your doctor about treatment options. Support groups are also good sources of information and support.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diffuse astrocytoma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

Last Updated: 7 Jan 2013

View Details
National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

Last Updated: 21 Nov 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diffuse astrocytoma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

http://www.abc2.org

Last Updated: 7 Jan 2013

View Details
National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

http://braintumor.org/

Last Updated: 21 Nov 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Diffuse astrocytoma" returned 9 free, full-text research articles on human participants. First 3 results:

TREATMENT OF PROGRESSION OF DIFFUSE ASTROCYTOMA BY HERBAL MEDICINE: CASE REPORT.
 

Author(s): Ivo Trogrlić, Dragan Trogrlić, Zoran Trogrlić

Journal:

 

The paper presents the results of the use of phytotherapy in a 33-year-old woman who, after finishing the oncological treatment of diffuse astrocytoma, had tumour progression.

Last Updated: 8 May 2017

Go To URL
Poly-ADP-Ribose Polymerase as a Therapeutic Target in Pediatric Diffuse Intrinsic Pontine Glioma and Pediatric High-Grade Astrocytoma.
 

Author(s): Yevgen Chornenkyy, Sameer Agnihotri, Man Yu, Pawel Buczkowicz, Patricia Rakopoulos, Brian Golbourn, Livia Garzia, Robert Siddaway, Stephie Leung, James T Rutka, Michael D Taylor, Peter B Dirks, Cynthia Hawkins

Journal: Mol. Cancer Ther.. 2015 Nov;14(11):2560-8.

 

Pediatric high-grade astrocytomas (pHGA) and diffuse intrinsic pontine gliomas (DIPG) are devastating malignancies for which no effective therapies exist. We investigated the therapeutic potential of PARP1 inhibition in preclinical models of pHGA and DIPG. PARP1 levels were characterized ...

Last Updated: 5 Nov 2015

Go To URL
Radial expansion rates and tumor growth kinetics predict malignant transformation in contrast-enhancing low-grade diffuse astrocytoma.
 

Author(s): Leith Hathout, Whitney B Pope, Albert Lai, Phioanh L Nghiemphu, Timothy F Cloughesy, Benjamin M Ellingson

Journal: CNS Oncol. 2015 ;4(4):247-56.

 

Contrast-enhancing low-grade diffuse astrocytomas are an understudied, aggressive subtype at increased risk because of few radiographic indications of malignant transformation. In the current study, we tested whether tumor growth kinetics could identify tumors that undergo malignant ...

Last Updated: 14 Jul 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Diffuse astrocytoma" returned 1 free, full-text review articles on human participants. First 3 results:

Supratentorial high-grade astrocytoma and diffuse brainstem glioma: two challenges for the pediatric oncologist.
 

Author(s): Alberto Broniscer, Amar Gajjar

Journal: Oncologist. 2004 ;9(2):197-206.

 

Pediatric high-grade gliomas represent a heterogeneous group of tumors that accounts for 15%-20% of all pediatric central nervous system tumors. These neoplasms predominantly involve the supratentorial hemispheres or the pons, in which case the tumors are usually called diffuse brainstem ...

Last Updated: 29 Mar 2004

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Everolimus With and Without Temozolomide in Adult Low Grade Glioma
 

Status: Recruiting

Condition Summary: Low Grade Glioma; WHO Grade II Astrocytomas; Oligodendrogliomas; Mixed Oligoastrocytomas

 

Last Updated: 27 Oct 2016

Go to URL
Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma
 

Status: Recruiting

Condition Summary: 1p/19q Co-deletion; Anaplastic Astrocytoma; Diffuse Astrocytoma; Glioma; IDH1 Gene Mutation; IDH2 Gene Mutation; Oligoastrocytoma; Oligodendroglioma; WHO Grade III Glioma

 

Last Updated: 6 Sep 2017

Go to URL
Radiation Therapy With or Without Temozolomide in Treating Patients With Low-Grade Glioma
 

Status: Recruiting

Condition Summary: Brain and Central Nervous System Tumors; Neurotoxicity

 

Last Updated: 4 Dec 2012

Go to URL