Lymphangioma

Common Name(s)

Lymphangioma

Lymphangioma is a benign (non-cancerous) mass made of fluid-filled spaces, which is thought to occur due to abnormal development of the lymphatic system. They are always present at birth, although they may change and become more apparent over time. Lymphangiomas are most commonly found in the head and neck region, but can affect almost any part of the body (except the brain). Some may appear as a tiny blue or red spot while others are massive and affect an entire limb (arm or leg). The signs and symptoms vary depending on the size and location of the mass; however, lymphangiomas can disfigure affected areas and potentially disrupt the function of nearby organs or tissues regardless of size. The exact underlying cause is unknown. Treatment options vary based on the signs and symptoms present in each person but may include surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lymphangioma" for support, advocacy or research.

Lymphangiomatosis & Gorham's Disease Alliance

Our mission is to improve the care of patients through our patient support programs, and by raising funds to support research that will identify effective treatments and cures. We strive to educate patients and families, and the medical and scientific communities, by providing important, relevant information, and by being the leading advocate for the worldwide member-community.

Last Updated: 5 Nov 2012

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Lymphatic Education & Research Network

Our Mission is to fight lymphatic disease and lymphedema through education, research and advocacy. We seek to accelerate the prevention, treatment and cure of the disease while bringing patients and medical professionals together to address the unmet needs surrounding lymphatic disorders.

Last Updated: 14 May 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lymphangioma" for support, advocacy or research.

Lymphangiomatosis & Gorham's Disease Alliance

Our mission is to improve the care of patients through our patient support programs, and by raising funds to support research that will identify effective treatments and cures. We strive to educate patients and families, and the medical and scientific communities, by providing important, relevant information, and by being the leading advocate for the worldwide member-community.

http://www.lgdalliance.org/

Last Updated: 5 Nov 2012

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Lymphatic Education & Research Network

Our Mission is to fight lymphatic disease and lymphedema through education, research and advocacy. We seek to accelerate the prevention, treatment and cure of the disease while bringing patients and medical professionals together to address the unmet needs surrounding lymphatic disorders.

http://www.lymphaticnetwork.org

Last Updated: 14 May 2014

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General Support Organizations

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General Resources

Lymphatic Malformation Research

The LGDA is closely affiliated with the Lymphatic Malformation Institute (LMI). The LMI receives requests for research projects into lymphatic diseases including lymphangiomatosis and Gorham's disease.

Updated 3 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lymphangioma" returned 249 free, full-text research articles on human participants. First 3 results:

Abdominal cystic lymphangioma in a term newborn: A case report and update of new treatments.
 

Author(s): Ilaria Amodeo, Giacomo Cavallaro, Genny Raffaeli, Lorenzo Colombo, Monica Fumagalli, Riccardo Cavalli, Ernesto Leva, Fabio Mosca

Journal: Medicine (Baltimore). 2017 Feb;96(8):e5984.

 

Lymphatic malformations are benign anomalies derived from the abnormal development of lymphatic channels. Usually asymptomatic, they can cause compression on adjacent structures or present acute complications (bleeding or infection). Small asymptomatic lesions can be conservatively ...

Last Updated: 22 Feb 2017

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Ileo-ileal intussusception caused by lymphangioma of the small bowel treated by single-incision laparoscopic-assisted ileal resection.
 

Author(s): Atsushi Kohga, Akihiro Kawabe, Yuto Hasegawa, Kiyoshige Yajima, Takuya Okumura, Kimihiro Yamashita, Jun Isogaki, Kenji Suzuki, Akira Komiyama

Journal: World J. Gastroenterol.. 2017 Jan;23(1):167-172.

 

Intraabdominal lymphangiomas are uncommon; additionally, those affecting the gastrointestinal tract are rare and account for less than 1% of cases. Intussusception caused by a cystic lymphangioma of the small bowel is extremely rare. The patient was a 20-year-old woman who visited ...

Last Updated: 20 Jan 2017

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[Cystic lymphangioma on the floor of the oral cavity extending to the submandibular region in adult patients].
 

Author(s): Elboukhari Ali, Nador Karim, Attifi Hicham, Zalagh Mohamed

Journal:

 

Cystic lymphangiomas are congenital benign lesions occurring predominantly in the head and neck area, especially in the posterior cervical triangle. These malformations involving the lymphatic vessels are frequently diagnosed in children. We report the clinical case of a 28-year-old ...

Last Updated: 31 Oct 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lymphangioma" returned 31 free, full-text review articles on human participants. First 3 results:

Sclerotherapy for Orbital Lymphangioma - Case Series and Literature Review.
 

Author(s): Karnesh Chandrakant Patel, George Kalantzis, Nabil El-Hindy, Bernard Y Chang

Journal: In Vivo. ;31(2):263-266.

 

Orbital lymphangioma is a lymphatic system lesion that commonly presents in childhood. Management of these lesions is complex. Sclerotherapy is a therapy used to treat and shrink lesions prior to or as an alternative to surgery. We present three cases of orbital lymphangioma that ...

Last Updated: 30 Mar 2017

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[Cervicothoracic cystic lymphangioma: about a case].
 

Author(s): Karim Nadour, Mountassir Moujahid

Journal:

 

Cervicothoracic cystic lymphangiomas are rare benign tumors developing from sequestration of embryonic lymph sac which is gradually filled with lymph fluid. The diagnosis is based on clinical signs (laterocervical swelling) and imaging (ultrasound and CT scan), then confirmed by histology ...

Last Updated: 15 Mar 2017

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[Retroperitoneal cystic lymphangioma: about 5 cases and review of the literature].
 

Author(s): Ahmed Saadi, Haroun Ayed, Omar Karray, Walid Kerkeni, Abderrazak Bouzouita, Mohamed Cherif, Riadh Ben Slama, Amine Derouiche, Mohamed Chebil

Journal:

 

Cystic lymphangioma is a rare, benign malformation of the lymphatic vessels which may be observed on various locations. Retroperitoneal location is less common than mesenteric location. Cystic lymphangioma has a polymorphic clinical presentation. Diagnosis is based on imaging but ...

Last Updated: 15 Mar 2017

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Efficacy of Rapamycin in the Treatment of Cervico-facial Lymphatic Malformations
 

Status: Not yet recruiting

Condition Summary: Lymphatic Malformation; Pediatric

 

Last Updated: 3 Aug 2017

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Sildenafil for the Treatment of Lymphatic Malformations
 

Status: Recruiting

Condition Summary: Lymphatic Malformations; Lymphatic Diseases

 

Last Updated: 9 May 2017

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Lymphatic Anomalies Registry
 

Status: Recruiting

Condition Summary: Lymphatic Malformation; Generalized Lymphatic Anomaly (GLA); Central Conducting Lymphatic Anomaly; CLOVES Syndrome; Gorham-Stout Disease ("Disappearing Bone Disease"); Blue Rubber Bleb Nevus Syndrome; Kaposiform Lymphangiomatosis; Kaposiform Hemangioendothelioma/Tufted Angioma; Klippel-Trenaunay Syndrome; Lymphangiomatosis

 

Last Updated: 26 Jul 2016

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