Lymphocytic hypophysitis

Common Name(s)

Lymphocytic hypophysitis

Lymphocytic hypophysitis (LH) is a condition in which the pituitary gland becomes infiltrated by lymphocytes, resulting in pituitary enlargement and impaired function. It most often occurs in women in late pregnancy or the postpartum period, but can also occur in prepubertal or post-menopausal women, and in men. Symptoms of LH may include headache, visual field impairment and more rarely, double vision (diplopia). The exact cause is unknown but is thought to be autoimmune-related. Although some cases resolve on their own or after a short course of steroids, other cases cause persistent problems even with aggressive medical or surgical treatment.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lymphocytic hypophysitis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lymphocytic hypophysitis" returned 41 free, full-text research articles on human participants. First 3 results:

Lymphocytic hypophysitis in nonpregnant middle-aged females mimicking pituitary adenoma.
 

Author(s): S Sankhe, J Gandhi, N S Shah, S Khare

Journal: J Postgrad Med. ;62(1):50-1.

 

Last Updated: 6 Jan 2016

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Clinical course of IgG4-related hypophysitis presenting with focal seizure and relapsing lymphocytic hypophysitis.
 

Author(s): Kanchana Ngaosuwan, Therdkiat Trongwongsa, Shanop Shuangshoti

Journal:

 

This is the first case report of focal seizure as a manifestation of Immunoglobulin G4 (IgG4)-related hypophysitis. IgG4-related hypophysitis is a novel category of hypophysitis. The clinical presentations, imaging studies and initial pathology studies can mimic lymphocytic hypophysitis. ...

Last Updated: 29 Oct 2015

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[Lymphocytic hypophysitis and hypertrophic pachymeningitis: description of a possible case associated to IgG4 pathologies].
 

Author(s): M Empar Blanco-Cantó, Pablo Dávila-González, Carlos López de Silanes, M Luz Cuadrado-Pérez, Gloria Ortega, Jesús Porta-Etessam

Journal: Rev Neurol. 2015 Jun;60(11):504-8.

 

Pathologies related to lymphocyte infiltration and inflammatory cells are classified, according to their topography, into idiopathic orbital pathology, idiopathic hypertrophic pachymeningitis, Tolosa-Hunt syndrome and lymphocytic hypophysitis. Here we review the case of a female patient ...

Last Updated: 25 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lymphocytic hypophysitis" returned 4 free, full-text review articles on human participants. First 3 results:

Lymphocytic hypophysitis accompanied by aseptic meningitis mimics subacute meningoencephalitis.
 

Author(s): Keisuke Suzuki, Naoki Izawa, Toshiki Nakamura, Kenichi Hashimoto, Keita Ouchi, Hideki Sakuta, Yohei Asakawa, Ayaka Numao, Koichi Hirata

Journal: Intern. Med.. 2011 ;50(18):2025-30.

 

A 66-year-old man was admitted to our hospital with muscle pain, fatigue and appetite loss that had lasted for a month. The patient was somnolent and had nuchal stiffness with a high fever. Cerebrospinal fluid (CSF) tests demonstrated lymphocytic pleocytosis with a decreased CSF-blood ...

Last Updated: 16 Sep 2011

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Lymphocytic hypophysitis: differential diagnosis and effects of high-dose pulse steroids, followed by azathioprine, on the pituitary mass and endocrine abnormalities--report of a case and literature review.
 

Author(s): Lorenzo Curtò, Maria L Torre, Oana R Cotta, Marco Losa, Maria R Terreni, Libero Santarpia, Francesco Trimarchi, Salvatore Cannavò

Journal:

 

We report on a man with a progressively increasing pituitary mass, as demonstrated by MRI. It produced neurological and ophthalmological symptoms, and, ultimately, hypopituitarism. MRI also showed enlargement of the pituitary stalk and a dural tail phenomenon. An increased titer of ...

Last Updated: 25 Jan 2010

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Lymphocytic hypophysitis: a rare or underestimated disease?
 

Author(s): Antonio Bellastella, Antonio Bizzarro, Concetta Coronella, Giuseppe Bellastella, Antonio Agostino Sinisi, Annamaria De Bellis

Journal: Eur. J. Endocrinol.. 2003 Nov;149(5):363-76.

 

Lymphocytic hypophysitis (LYH) is an uncommon autoimmune disease in which the pituitary gland is infiltrated by lymphocytes, plasma cells and macrophages and its function is usually impaired. It has to be suspected in pregnant women and in women with recent delivery presenting with ...

Last Updated: 30 Oct 2003

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.