Major depressive disorder

Common Name(s)

Major depressive disorder, Major depression

Major depressive disorder is a serious form of depression which involves some combination of the following symptoms: sadness, inability to concentrate, difficulty sleeping (insomnia) or sleeping too much, feeling very tired (fatigue), weight gain or loss, irritability, loss of interest or pleasure in activities, feelings of guilt, worthlessness or hopelessness, and thoughts of suicide. It affects a person’s thoughts, moods, behavior and physical health. A major depressive episode usually lasts more than 2 weeks and interferes with a person’s ability to perform daily functions. Some people may only experience one episode, but others may experience multiple episodes in their lifetime. The cause of major depressive disorder is unknown. It may affect anyone of any age, race, ethnicity, gender or socioeconomic level. Certain factors increase a person’s risk including experiencing traumatic or stressful event(s), having a serious or chronic illness or anxiety related disorder, or having a family history of depression. Those who abuse alcohol or drugs are also at an increased risk.

Major depressive disorder is a serious illness. Without treatment an episode may continue with symptoms becoming increasingly more serious. Major depressive episodes may lead a person to feel that life is not worth living and to commit suicide. If you or someone you know is having thoughts of suicide call a suicide hot line or go to an emergency medical center. It is important to realize that depression is treatable. Treatment may include support groups, medication, talk therapy, or other strategies. Talk to your doctor to decide on the best treatment options if you or a family member is affected by major depression. Support groups are also a good source of up to date information and can help connect you with others affected by depression. See also depression.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Major depressive disorder" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Major depressive disorder" returned 1096 free, full-text research articles on human participants. First 3 results:

Major depressive disorder and suicide risk among adult outpatients at several general hospitals in a Chinese Han population.
 

Author(s): Haiyan Li, Xinni Luo, Xiaoyin Ke, Qing Dai, Wei Zheng, Chanjuan Zhang, Ryan M Cassidy, Jair C Soares, XiangYang Zhang, Yuping Ning

Journal:

 

Somatic complaints are often the presenting symptoms of major depressive disorder (MDD) in the outpatient context, because this may go unrecognized. It is well understood that MDD carries an increased risk of suicide. This study aimed to identify the risk factors and association with ...

Last Updated: 10 Oct 2017

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Efficacy of escitalopram monotherapy in the treatment of major depressive disorder: A pooled analysis of 4 Chinese clinical trials.
 

Author(s): Guanjun Li, Yifeng Shen, Jianfeng Luo, Huafang Li

Journal: Medicine (Baltimore). 2017 Sep;96(39):e8142.

 

This study aimed to evaluate the efficacy of escitalopram monotherapy in the treatment of major depressive disorder (MDD) on the basis of pooled data analysis of 4 Chinese clinical trials.A total of 649 outpatients with MDD score of ≥18 at the 17-item Hamilton Depression Rating ...

Last Updated: 27 Sep 2017

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The temperament and character traits in patients with major depressive disorder and bipolar affective disorder with and without suicide attempt.
 

Author(s): Anamarija Petek Erić, Ivan Erić, Mario Ćurković, Katarina Dodig-Ćurković, Kristina Kralik, Vlatka Kovač, Pavo Filaković

Journal: Psychiatr Danub. 2017 Jun;29(2):171-178.

 

Suicide and mood disorders (especially major depressive disorder (MDD) and bipolar affective disorder (BD)) represent a significant global health burden. Major depressive disorder and bipolar affective disorder have been associated with increased risk for suicide. Some specific suicide ...

Last Updated: 21 Jun 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Major depressive disorder" returned 170 free, full-text review articles on human participants. First 3 results:

Florida Best Practice Psychotherapeutic Medication Guidelines for Adults With Major Depressive Disorder.
 

Author(s): Roger S McIntyre, Trisha Suppes, Rajiv Tandon, Michael Ostacher

Journal: J Clin Psychiatry. 2017 Jun;78(6):703-713.

 

Herein we provide the 2015 update for the Florida Best Practice Psychotherapeutic Medication Guidelines (FPG) for major depressive disorder (MDD). The FPG represent evidence-based decision support for practitioners providing care to adults with MDD.

Last Updated: 6 Jul 2017

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Selective serotonin reuptake inhibitors versus placebo in patients with major depressive disorder. A systematic review with meta-analysis and Trial Sequential Analysis.
 

Author(s): Janus Christian Jakobsen, Kiran Kumar Katakam, Anne Schou, Signe Gade Hellmuth, Sandra Elkjær Stallknecht, Katja Leth-Møller, Maria Iversen, Marianne Bjørnø Banke, Iggiannguaq Juhl Petersen, Sarah Louise Klingenberg, Jesper Krogh, Sebastian Elgaard Ebert, Anne Timm, Jane Lindschou, Christian Gluud

Journal:

 

The evidence on selective serotonin reuptake inhibitors (SSRIs) for major depressive disorder is unclear.

Last Updated: 9 Feb 2017

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Indicators of patients with major depressive disorder in need of highly specialized care: A systematic review.
 

Author(s): Frédérique C W van Krugten, Meriam Kaddouri, Maartje Goorden, Anton J L M van Balkom, Claudi L H Bockting, Frenk P M L Peeters, Leona Hakkaart-van Roijen,

Journal:

 

Early identification of patients with major depressive disorder (MDD) that cannot be managed by secondary mental health services and who require highly specialized mental healthcare could enhance need-based patient stratification. This, in turn, may reduce the number of treatment ...

Last Updated: 8 Feb 2017

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Fish Oil as Adjunct Treatment for Major Depressive Disorder
 

Status: Recruiting

Condition Summary: Major Depressive Disorder

 

Last Updated: 6 Oct 2017

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Open Label Ketamine Treatment for Major Depressive Disorder in Veterans
 

Status: Recruiting

Condition Summary: Major Depressive Disorder

 

Last Updated: 20 Jul 2017

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Music Therapy for Major Depressive Disorder Residual Symptoms
 

Status: Recruiting

Condition Summary: Major Depressive Disorder

 

Last Updated: 4 Oct 2016

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