Malignant germ cell tumor

Common Name(s)

Malignant germ cell tumor

Malignant germ cell tumor is a rare form of cancer characterized by abnormal cell growth of immature cells that develop into male and female reproductive systems. Individuals with this disorder may grow harmful tumors in the ovaries, testes, abdomen, pelvis or lower back, which can spread to the rest of the body if not diagnosed and treated early. This form of cancer can thus cause individuals to lose reproductive ability. Common symptoms include weight loss, abdominal pain and breathing problems. An individual may also feel a mass or growth in their abdomen. Diagnosis may require blood tests and imaging studies such as a CT scan. A physician may also need to take a biopsy, which is where they surgically remove a small portion of the tumor to look at under a microscope. Treatment is developed on a case-by-case basis and may include a combination of chemotherapy, radiation, and surgery.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Malignant germ cell tumor" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Malignant germ cell tumor" returned 24 free, full-text research articles on human participants. First 3 results:

Safety and efficacy of bleomycin/pingyangmycin-containing chemotherapy regimens for malignant germ cell tumor patients in the female genital system.
 

Author(s): Qianying Zhao, Dongyan Cao, Mei Yu, Jiaxin Yang, Yongjian Liu, Yang Xiang, Ming Wu, Lingya Pan, Jinghe Lang, Kaifeng Xu, Jiangna Han, Keng Shen

Journal: Oncotarget. 2017 Feb;8(9):15952-15960.

 

To comprehensively evaluate the safety and effectiveness of bleomycin/pingyangmycin-containing chemotherapy for female patients with malignant germ cell tumors in their genital system; to assess the diagnostic value of pulmonary function tests for bleomycin-induced pulmonary toxicity.

Last Updated: 4 Feb 2017

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Swyer's Syndrome with Mixed Ovarian Malignant Germ Cell Tumor and Ovarian Gonadoblastoma.
 

Author(s): Hong-Lan Zhu, Dong-Mei Bao, Yue Wang, Dan-Hua Shen, Yi Li, Heng Cui

Journal: Chin. Med. J.. 2016 Jul;129(14):1752-4.

 

Last Updated: 14 Jul 2016

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Ovarian malignant mixed germ cell tumor: A rare combination with five germ cell components.
 

Author(s): Sinai Khandeparkar Siddhi Gaurish, Joshi Avinash, Shalaka Hardas, Maithili Mandar Kulkarni, Chitrangi Prashant Barpande

Journal: Indian J Pathol Microbiol. ;59(1):122-3.

 

Last Updated: 10 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Malignant germ cell tumor" returned 2 free, full-text review articles on human participants. First 3 results:

Unclassified mixed germ cell-sex cord-stromal tumor with multiple malignant cellular elements in a young woman: a case report and review of the literature.
 

Author(s): Shujie Pang, Lin Zhang, Yiquan Shi, Yixin Liu

Journal:

 

Unclassified mixed germ cell-sex cord-stromal tumor composed of germ cells and sex cord derivatives is a rare neoplasm. Approximately 10% of such tumors have malignant germ cell components. We report the case of a 28 year-old female with a right adnexal mass measuring 8 cm in greatest ...

Last Updated: 8 Sep 2014

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False-positive serum human chorionic gonadotropin (HCG) in a male patient with a malignant germ cell tumor of the testis: a case report and review of the literature.
 

Author(s): Bart E P B Ballieux, Nir I Weijl, Hans Gelderblom, Johannes van Pelt, Susanne Osanto

Journal: Oncologist. 2008 Nov;13(11):1149-54.

 

A 39-year-old male patient with a favorable prognosis stage IIB metastatic malignant germ cell tumor (GCT) and elevated pre- and postorchiectomy serum human chorionic gonadotropin (hCG) was treated with three courses of combination chemotherapy resulting in a rapid normalization of ...

Last Updated: 25 Nov 2008

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 30 Mar 2016

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Pediatric MATCH: PI3K/mTOR Inhibitor LY3023414 in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations
 

Status: Recruiting

Condition Summary: Advanced Malignant Solid Neoplasm; Malignant Glioma; Recurrent Central Nervous System Neoplasm; Recurrent Childhood Ependymoma; Recurrent Childhood Malignant Germ Cell Tumor; Recurrent Childhood Medulloblastoma; Recurrent Childhood Non-Hodgkin Lymphoma; Recurrent Childhood Rhabdomyosarcoma; Recurrent Childhood Soft Tissue Sarcoma; Recurrent Ewing Sarcoma; Recurrent Glioma; Recurrent Hepatoblastoma; Recurrent Langerhans Cell Histiocytosis; Recurrent Malignant Solid Neoplasm; Recurrent Neuroblastoma; Recurrent Osteosarcoma; Recurrent Peripheral Primitive Neuroectodermal Tumor; Refractory Central Nervous System Neoplasm; Refractory Childhood Malignant Germ Cell Tumor; Refractory Langerhans Cell Histiocytosis; Refractory Malignant Solid Neoplasm; Refractory Neuroblastoma; Refractory Non-Hodgkin Lymphoma; Rhabdoid Tumor; Stage III Childhood Non-Hodgkin Lymphoma; Stage III Osteosarcoma AJCC v7; Stage III Soft Tissue Sarcoma AJCC v7; Stage IV Childhood Non-Hodgkin Lymphoma; Stage IV Osteosarcoma AJCC v7; Stage IV Soft Tissue Sarcoma AJCC v7; Stage IVA Osteosarcoma AJCC v7; Stage IVB Osteosarcoma AJCC v7; TSC1 Gene Mutation; TSC2 Gene Mutation; Wilms Tumor

 

Last Updated: 13 Nov 2017

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Pediatric MATCH: Trk Inhibitor LOXO-101 in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions
 

Status: Recruiting

Condition Summary: Advanced Malignant Solid Neoplasm; Malignant Glioma; NTRK1 Fusion Positive; NTRK2 Fusion Positive; NTRK3 Fusion Positive; Recurrent Central Nervous System Neoplasm; Recurrent Childhood Ependymoma; Recurrent Childhood Malignant Germ Cell Tumor; Recurrent Childhood Medulloblastoma; Recurrent Childhood Non-Hodgkin Lymphoma; Recurrent Childhood Rhabdomyosarcoma; Recurrent Childhood Soft Tissue Sarcoma; Recurrent Ewing Sarcoma; Recurrent Glioma; Recurrent Hepatoblastoma; Recurrent Langerhans Cell Histiocytosis; Recurrent Malignant Solid Neoplasm; Recurrent Neuroblastoma; Recurrent Osteosarcoma; Recurrent Peripheral Primitive Neuroectodermal Tumor; Refractory Central Nervous System Neoplasm; Refractory Childhood Malignant Germ Cell Tumor; Refractory Langerhans Cell Histiocytosis; Refractory Malignant Solid Neoplasm; Refractory Neuroblastoma; Refractory Non-Hodgkin Lymphoma; Rhabdoid Tumor; Stage III Childhood Non-Hodgkin Lymphoma; Stage III Osteosarcoma AJCC v7; Stage III Soft Tissue Sarcoma AJCC v7; Stage IV Childhood Non-Hodgkin Lymphoma; Stage IV Osteosarcoma AJCC v7; Stage IV Soft Tissue Sarcoma AJCC v7; Stage IVA Osteosarcoma AJCC v7; Stage IVB Osteosarcoma AJCC v7; Wilms Tumor

 

Last Updated: 13 Nov 2017

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