Malignant mesothelioma

Common Name(s)

Malignant mesothelioma

Malignant mesothelioma is an aggressive neoplasm of the serosal lining of the chest etiologically linked to asbestos. It is diagnosed in approximately 2,000 to 3,000 individuals annually in the United States, most of whom die within 2 years of diagnosis (summary by {6:Bott et al., 2011}). See also {614327} for a tumor predisposition syndrome that may contribute to the development of malignant mesothelioma upon asbestos exposure and is caused by germline mutation in the BAP1 gene ({603089}) on chromosome 3p21.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Malignant mesothelioma" for support, advocacy or research.

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Mesothelioma Applied Research Foundation

The Mesothelioma Applied Research Foundation is the nonprofit collaboration of patients and families, physicians, advocates, and researchers dedicated to eradicating the life-ending and vicious effects of mesothelioma. We believe in a cure for meso. Given the human toll of suffering the disease causes, the compassion and energy of the meso community, the moral, legal and economic aspects of asbestos, and the benefits of meso research to cancer research generally, we believe that the resources to accomplish this cure are available and must be mobilized. We seek to marshal and utilize these resources responsibly, as effectively as possible, with financial transparency and by adhering to health policy guidelines that foster ethical clinical and administrative practices, and ethical decision making to: • Offer hope and support to patients and families by educating them on the disease, helping them to obtain the most up-to-date information on treatment options and to connect with meso tr

Last Updated: 1 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Malignant mesothelioma" for support, advocacy or research.

Logo
Mesothelioma Applied Research Foundation

The Mesothelioma Applied Research Foundation is the nonprofit collaboration of patients and families, physicians, advocates, and researchers dedicated to eradicating the life-ending and vicious effects of mesothelioma. We believe in a cure for meso. Given the human toll of suffering the disease causes, the compassion and energy of the meso community, the moral, legal and economic aspects of asbestos, and the benefits of meso research to cancer research generally, we believe that the resources to accomplish this cure are available and must be mobilized. We seek to marshal and utilize these resources responsibly, as effectively as possible, with financial transparency and by adhering to health policy guidelines that foster ethical clinical and administrative practices, and ethical decision making to: • Offer hope and support to patients and families by educating them on the disease, helping them to obtain the most up-to-date information on treatment options and to connect with meso tr

http://www.curemeso.org

Last Updated: 1 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Malignant mesothelioma" returned 1084 free, full-text research articles on human participants. First 3 results:

Pleural effusion biomarkers and computed tomography findings in diagnosing malignant pleural mesothelioma: A retrospective study in a single center.
 

Author(s): Takehiro Otoshi, Yuki Kataoka, Shunkichi Ikegaki, Emiko Saito, Hirotaka Matsumoto, Sawako Kaku, Masatoshi Shimada, Masataka Hirabayashi

Journal:

 

In this study, we aimed to examine the clinical value of the pleural effusion (PE) biomarkers, soluble mesothelin-related peptide (SMRP), cytokeratin 19 fragment (CYFRA 21-1) and carcinoembryonic antigen (CEA), and the utility of combining chest computed tomography (CT) findings with ...

Last Updated: 31 Dec 1969

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Estimated future incidence of malignant mesothelioma in South Korea: Projection from 2014 to 2033.
 

Author(s): Kyeong Min Kwak, Domyung Paek, Seung-Sik Hwang, Young-Su Ju

Journal:

 

Malignant mesothelioma is a malignant tumor on the pleura or the peritoneum caused mostly by asbestos. Although asbestos is not currently used in South Korea, the incidence of mesothelioma is increasing due to its long latent period. This study predicted the incidence of malignant ...

Last Updated: 31 Dec 1969

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Synthetic lethality in malignant pleural mesothelioma with PARP1 inhibition.
 

Author(s): Gayathri Srinivasan, Gurjit Singh Sidhu, Elizabeth A Williamson, Aruna S Jaiswal, Nasreen Najmunnisa, Keith Wilcoxen, Dennie Jones, Thomas J George, Robert Hromas

Journal: Cancer Chemother. Pharmacol.. 2017 Oct;80(4):861-867.

 

Malignant pleural mesotheliomas (MPM) are most often surgically unresectable, and they respond poorly to current chemotherapy and radiation therapy. Between 23 and 64% of malignant pleural mesothelioma have somatic inactivating mutations in the BAP1 gene. BAP1 is a homologous recombination ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Malignant mesothelioma" returned 107 free, full-text review articles on human participants. First 3 results:

Malignant Mesothelioma Biomarkers: From Discovery to Use in Clinical Practice for Diagnosis, Monitoring, Screening, and Treatment.
 

Author(s): Jenette Creaney, Bruce W S Robinson

Journal: Chest. 2017 Jul;152(1):143-149.

 

Malignant pleural mesothelioma is a highly aggressive tumor associated with asbestos exposure. There are few effective treatment options for mesothelioma, and patients have a very poor prognosis with a median survival of < 12 months from diagnosis. Biomarkers have been proposed ...

Last Updated: 31 Dec 1969

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Malignant pleural mesothelioma: an update on investigation, diagnosis and treatment.
 

Author(s): Anna C Bibby, Selina Tsim, Nikolaos Kanellakis, Hannah Ball, Denis C Talbot, Kevin G Blyth, Nick A Maskell, Ioannis Psallidas

Journal: Eur Respir Rev. 2016 Dec;25(142):472-486.

 

Malignant pleural mesothelioma is an aggressive malignancy of the pleural surface, predominantly caused by prior asbestos exposure. There is a global epidemic of malignant pleural mesothelioma underway, and incidence rates are predicted to peak in the next few years.This article summarises ...

Last Updated: 31 Dec 1969

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Malignant mesothelioma of the pleura with desmoplastic histology: a case series and literature review.
 

Author(s): Kana Hashimoto, Yusuke Okuma, Yukio Hosomi, Tsunekazu Hishima

Journal:

 

Desmoplastic malignant pleural mesothelioma (DMM) is rare histological subtype of diffuse malignant pleural mesothelioma (MPM), accounting for 5-10 % of cases. It has a poor prognosis, with direct invasion of the chest wall or lungs and distant metastases. Its pathological characteristics ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Stereotactic Body Radiation Therapy and Avelumab Immunotherapy for Treatment of Malignant Mesothelioma
 

Status: Recruiting

Condition Summary: Malignant Mesothelioma (MPM)

 

Last Updated: 9 Jan 2018

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Tissue Procurement and Natural History Study of Patients With Malignant Mesothelioma
 

Status: Recruiting

Condition Summary: Mesothelioma

 

Last Updated: 26 Oct 2017

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Safety and Efficacy of Oshadi D and Oshadi R for Malignant Mesothelioma Treatment
 

Status: Not yet recruiting

Condition Summary: Mesothelioma

 

Last Updated: 28 Mar 2016

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