Malignant pheochromocytoma

Common Name(s)

Malignant pheochromocytoma

Malignant pheochromocytoma as opposed to benign, is a form of pheochromocytoma that is cancerous. Pheochromocytoma is a rare, usually noncancerous (benign) tumor that develops in cells in the center of an adrenal gland. There are two adrenal glands in the human body, one on the top of each kidney. They are shaped like triangles, and each is about a ½ inch high and 3 inches long.

Headache, sweating, and a fast heartbeat are typical symptoms of pheochromocytoma, usually in association with markedly high blood pressure.

However, less than 10 percent of pheochromocytoma's surgically removed are found to be malignant. Treatment options for malignancy include surgery, radiation, and chemotherapy. Research in this field is rapidly progressing.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Malignant pheochromocytoma" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Malignant pheochromocytoma" returned 64 free, full-text research articles on human participants. First 3 results:

Primary malignant lymphoma combined with clinically "silent" pheochromocytoma in the same adrenal gland.
 

Author(s): Anna Babinska, Rafał Peksa, Krzysztof Sworczak

Journal:

 

An increased number of adrenal tumors are now diagnosed due to the increased number of abdominal CT scans being performed. We present the first case of malignant lymphoma combined with clinically "silent" pheochromocytoma in the same adrenal gland. An abdominal CT scan demonstrates ...

Last Updated: 30 Sep 2015

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Expression of the pituitary tumor transforming gene (PTTG1) in pheochromocytoma as a potential marker for distinguishing benign versus malignant tumors.
 

Author(s): Mohamad Reza Haji Amousha, Nastaran Sabetkish, Nastaran Sabet Kish, Ramin Heshmat, Afsaneh Rajabiani, Hiva Saffar, Vahid Haghpanah, Seyed Mohammad Tavangar

Journal: Acta Med Iran. 2015 ;53(4):236-41.

 

The Distinction between malignant and benign pheochromocytoma has always been a diagnostic challenge over the last decades. To date, the only reliable criterion is metastasis. The aim of the present study was to investigate the possible expression of pituitary-tumor transforming gene ...

Last Updated: 15 Apr 2015

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[A case of multiple bony pain due to metastatic malignant pheochromocytoma successfully treated with strontium-89].
 

Author(s): Teppei Takeshima, Kazuhiro Namura, Zenkichi Sekiguchi, Akitoshi Takizawa, Futoshi Tsuchiya, Akira Iwasaki, Shigeyuki Ogi

Journal: Hinyokika Kiyo. 2014 Mar;60(3):109-13.

 

A 50-year-old woman complaining of right flank pain visited our hospital. Computed tomography revealed adrenal gland tumor measuring 10 cm in diameter, and multiple bone and liver metastases. It was diagnosed as a malignant pheochromocytoma by means of endocrinological examination ...

Last Updated: 24 Apr 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Malignant pheochromocytoma" returned 7 free, full-text review articles on human participants. First 3 results:

Therapy of endocrine disease: treatment of malignant pheochromocytoma and paraganglioma.
 

Author(s): Eric Baudin, Mouhammed Amir Habra, Frederic Deschamps, Gilbert Cote, Frederic Dumont, Maria Cabanillas, J Arfi-Roufe, A Berdelou, Bryan Moon, Abir Al Ghuzlan, Shreyaskumar Patel, Sophie Leboulleux, Camilo Jimenez

Journal: Eur. J. Endocrinol.. 2014 Sep;171(3):R111-22.

 

Metastatic pheochromocytomas and paragangliomas (MPPs) present clinicians with three major challenges: scarcity, complexity of characterization, and heterogeneous behavior and prognosis. As with the treatment for all neuroendocrine tumors, the control of hormonal symptoms and tumor ...

Last Updated: 23 Jul 2014

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Changing paradigms in the treatment of malignant pheochromocytoma.
 

Author(s): Raymon H Grogan, Elliot J Mitmaker, Quan-Yang Duh

Journal: Cancer Control. 2011 Apr;18(2):104-12.

 

Pheochromocytomas and paragangliomas are intra- and extra-adrenal neoplasms that are rarely malignant. The treatment of those that are malignant has remained a challenge because little was known about the molecular pathways involved in its malignant transformation. Recently, however, ...

Last Updated: 31 Mar 2011

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Malignant pheochromocytoma with liver metastasis treated by transcatheter arterial chemo-embolization (TACE).
 

Author(s): Satoshi Hidaka, Atsushi Hiraoka, Hironori Ochi, Takahide Uehara, Tomoyuki Ninomiya, Yasunao Miyamoto, Aki Hasebe, Tetsuya Tanihira, Atsushi Tanabe, Misa Ichiryu, Hiromasa Nakahara, Nayu Tazuya, Iku Ninomiya, Kojiro Michitaka

Journal: Intern. Med.. 2010 ;49(7):645-51.

 

Multiple liver metastatic lesions were shown by computed tomography and scintigraphy with 123I- metaiodobenzylguanidine (MIBG) in a 76-year-old woman 2 years after resection of a pheochromocytoma of the right adrenal gland. Transcatheter arterial chemo-embolization (TACE) was performed ...

Last Updated: 7 Apr 2010

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Compassionate Use of 131I-MIBG for Patients With Malignant Pheochromocytoma
 

Status: Available

Condition Summary: Pheochromocytoma; Paraganglioma

 

Last Updated: 23 Dec 2014

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Cabozantinib for Malignant Pheochromocytoma
 

Status: Recruiting

Condition Summary: Neuroendocrine Tumors

 

Last Updated: 14 Nov 2016

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