Malignant pheochromocytoma

Common Name(s)

Malignant pheochromocytoma

Malignant pheochromocytoma as opposed to benign, is a form of pheochromocytoma that is cancerous. Pheochromocytoma is a rare, usually noncancerous (benign) tumor that develops in cells in the center of an adrenal gland. There are two adrenal glands in the human body, one on the top of each kidney. They are shaped like triangles, and each is about a ½ inch high and 3 inches long.

Headache, sweating, and a fast heartbeat are typical symptoms of pheochromocytoma, usually in association with markedly high blood pressure.

However, less than 10 percent of pheochromocytoma's surgically removed are found to be malignant. Treatment options for malignancy include surgery, radiation, and chemotherapy. Research in this field is rapidly progressing.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Malignant pheochromocytoma" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Malignant pheochromocytoma" returned 70 free, full-text research articles on human participants. First 3 results:

Adrenal malignant melanoma masquerading as a pheochromocytoma in a patient with a history of a multifocal papillary and medullary thyroid carcinoma.
 

Author(s): Maria E Barmpari, Christos Savvidis, Anastasia D Dede, Haridimos Markogiannakis, Christina Dikoglou, Paraskevi Xekouki, Constantine A Stratakis, Andreas Manouras, Sofia Malaktari-Skarantavou

Journal: Hormones (Athens). 2016 Apr;15(2):283-90.

 

Adrenal masses usually represent benign and nonfunctional adrenal adenomas; however, primary or metastatic malignancy should also be considered. Discovery of an adrenal mass needs further evaluation in order to exclude malignancy and hormonal secretion. We present a rare case of a ...

Last Updated: 5 Jul 2016

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Primary malignant lymphoma combined with clinically "silent" pheochromocytoma in the same adrenal gland.
 

Author(s): Anna Babinska, Rafał Peksa, Krzysztof Sworczak

Journal:

 

An increased number of adrenal tumors are now diagnosed due to the increased number of abdominal CT scans being performed. We present the first case of malignant lymphoma combined with clinically "silent" pheochromocytoma in the same adrenal gland. An abdominal CT scan demonstrates ...

Last Updated: 30 Sep 2015

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Expression of the pituitary tumor transforming gene (PTTG1) in pheochromocytoma as a potential marker for distinguishing benign versus malignant tumors.
 

Author(s): Mohamad Reza Haji Amousha, Nastaran Sabetkish, Nastaran Sabet Kish, Ramin Heshmat, Afsaneh Rajabiani, Hiva Saffar, Vahid Haghpanah, Seyed Mohammad Tavangar

Journal: Acta Med Iran. 2015 ;53(4):236-41.

 

The Distinction between malignant and benign pheochromocytoma has always been a diagnostic challenge over the last decades. To date, the only reliable criterion is metastasis. The aim of the present study was to investigate the possible expression of pituitary-tumor transforming gene ...

Last Updated: 15 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Malignant pheochromocytoma" returned 10 free, full-text review articles on human participants. First 3 results:

Composite pheochromocytoma with a malignant peripheral nerve sheath tumor: Case report and review of the literature.
 

Author(s): Takeshi Namekawa, Takanobu Utsumi, Takashi Imamoto, Koji Kawamura, Takashi Oide, Tomoaki Tanaka, Naoki Nihei, Hiroyoshi Suzuki, Yukio Nakatani, Tomohiko Ichikawa

Journal: Asian J Surg. 2016 Jul;39(3):187-90.

 

Adrenal tumors with more than one cellular component are uncommon. Furthermore, an adrenal tumor composed of a pheochromocytoma and a malignant peripheral nerve sheath tumor is extremely rare. A composite pheochromocytoma with malignant peripheral nerve sheath tumor in a 42-year-old ...

Last Updated: 24 Jun 2016

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Therapy of endocrine disease: treatment of malignant pheochromocytoma and paraganglioma.
 

Author(s): Eric Baudin, Mouhammed Amir Habra, Frederic Deschamps, Gilbert Cote, Frederic Dumont, Maria Cabanillas, J Arfi-Roufe, A Berdelou, Bryan Moon, Abir Al Ghuzlan, Shreyaskumar Patel, Sophie Leboulleux, Camilo Jimenez

Journal: Eur. J. Endocrinol.. 2014 Sep;171(3):R111-22.

 

Metastatic pheochromocytomas and paragangliomas (MPPs) present clinicians with three major challenges: scarcity, complexity of characterization, and heterogeneous behavior and prognosis. As with the treatment for all neuroendocrine tumors, the control of hormonal symptoms and tumor ...

Last Updated: 23 Jul 2014

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Changing paradigms in the treatment of malignant pheochromocytoma.
 

Author(s): Raymon H Grogan, Elliot J Mitmaker, Quan-Yang Duh

Journal: Cancer Control. 2011 Apr;18(2):104-12.

 

Pheochromocytomas and paragangliomas are intra- and extra-adrenal neoplasms that are rarely malignant. The treatment of those that are malignant has remained a challenge because little was known about the molecular pathways involved in its malignant transformation. Recently, however, ...

Last Updated: 31 Mar 2011

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Compassionate Use of 131I-MIBG for Patients With Malignant Pheochromocytoma
 

Status: Available

Condition Summary: Pheochromocytoma; Paraganglioma

 

Last Updated: 23 Dec 2014

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Cabozantinib for Malignant Pheochromocytoma
 

Status: Recruiting

Condition Summary: Neuroendocrine Tumors

 

Last Updated: 17 Apr 2017

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