Malignant pheochromocytoma

Common Name(s)

Malignant pheochromocytoma

Malignant pheochromocytoma as opposed to benign, is a form of pheochromocytoma that is cancerous. Pheochromocytoma is a rare, usually noncancerous (benign) tumor that develops in cells in the center of an adrenal gland. There are two adrenal glands in the human body, one on the top of each kidney. They are shaped like triangles, and each is about a ½ inch high and 3 inches long.

Headache, sweating, and a fast heartbeat are typical symptoms of pheochromocytoma, usually in association with markedly high blood pressure.

However, less than 10 percent of pheochromocytoma's surgically removed are found to be malignant. Treatment options for malignancy include surgery, radiation, and chemotherapy. Research in this field is rapidly progressing.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Malignant pheochromocytoma" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Malignant pheochromocytoma" returned 73 free, full-text research articles on human participants. First 3 results:

Adrenal malignant melanoma masquerading as a pheochromocytoma in a patient with a history of a multifocal papillary and medullary thyroid carcinoma.
 

Author(s): Maria E Barmpari, Christos Savvidis, Anastasia D Dede, Haridimos Markogiannakis, Christina Dikoglou, Paraskevi Xekouki, Constantine A Stratakis, Andreas Manouras, Sofia Malaktari-Skarantavou

Journal: Hormones (Athens). 2016 Apr;15(2):283-90.

 

Adrenal masses usually represent benign and nonfunctional adrenal adenomas; however, primary or metastatic malignancy should also be considered. Discovery of an adrenal mass needs further evaluation in order to exclude malignancy and hormonal secretion. We present a rare case of a ...

Last Updated: 31 Dec 1969

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Phenylethanolamine N-methyltransferase downregulation is associated with malignant pheochromocytoma/paraganglioma.
 

Author(s): Seung Eun Lee, Ensel Oh, Boram Lee, Yu Jin Kim, Doo-Yi Oh, Kyungsoo Jung, Jong-Sun Choi, Junghan Kim, Sung Joo Kim, Jung Wook Yang, Jungsuk An, Young Lyun Oh, Yoon La Choi

Journal: Oncotarget. 2016 Apr;7(17):24141-53.

 

Malignant pheochromocytoma/paraganglioma (PCC/PGL) is defined by the presence of metastases at non-chromaffin sites, which makes it difficult to prospectively diagnose malignancy. Here, we performed array CGH (aCGH) and paired gene expression profiling of fresh, frozen PCC/PGL samples ...

Last Updated: 31 Dec 1969

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Primary malignant lymphoma combined with clinically "silent" pheochromocytoma in the same adrenal gland.
 

Author(s): Anna Babinska, Rafał Peksa, Krzysztof Sworczak

Journal:

 

An increased number of adrenal tumors are now diagnosed due to the increased number of abdominal CT scans being performed. We present the first case of malignant lymphoma combined with clinically "silent" pheochromocytoma in the same adrenal gland. An abdominal CT scan demonstrates ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Malignant pheochromocytoma" returned 10 free, full-text review articles on human participants. First 3 results:

Malignant pheochromocytoma with multiple vertebral metastases causing acute incomplete paralysis during pregnancy: Literature review with one case report.
 

Author(s): Shuzhong Liu, An Song, Xi Zhou, Xiangyi Kong, William A Li, Yipeng Wang, Yong Liu

Journal: Medicine (Baltimore). 2017 Nov;96(44):e8535.

 

We present a rare case of malignant pheochromocytoma with thoracic metastases during pregnancy that presented with symptoms of myelopathy and was treated with circumferential decompression, stabilization, and radiation. The management of this unique case is not well documented. The ...

Last Updated: 31 Dec 1969

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Composite pheochromocytoma with a malignant peripheral nerve sheath tumor: Case report and review of the literature.
 

Author(s): Takeshi Namekawa, Takanobu Utsumi, Takashi Imamoto, Koji Kawamura, Takashi Oide, Tomoaki Tanaka, Naoki Nihei, Hiroyoshi Suzuki, Yukio Nakatani, Tomohiko Ichikawa

Journal: Asian J Surg. 2016 Jul;39(3):187-90.

 

Adrenal tumors with more than one cellular component are uncommon. Furthermore, an adrenal tumor composed of a pheochromocytoma and a malignant peripheral nerve sheath tumor is extremely rare. A composite pheochromocytoma with malignant peripheral nerve sheath tumor in a 42-year-old ...

Last Updated: 31 Dec 1969

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Therapy of endocrine disease: treatment of malignant pheochromocytoma and paraganglioma.
 

Author(s): Eric Baudin, Mouhammed Amir Habra, Frederic Deschamps, Gilbert Cote, Frederic Dumont, Maria Cabanillas, J Arfi-Roufe, A Berdelou, Bryan Moon, Abir Al Ghuzlan, Shreyaskumar Patel, Sophie Leboulleux, Camilo Jimenez

Journal: Eur. J. Endocrinol.. 2014 Sep;171(3):R111-22.

 

Metastatic pheochromocytomas and paragangliomas (MPPs) present clinicians with three major challenges: scarcity, complexity of characterization, and heterogeneous behavior and prognosis. As with the treatment for all neuroendocrine tumors, the control of hormonal symptoms and tumor ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Compassionate Use of 131I-MIBG for Patients With Malignant Pheochromocytoma
 

Status: Available

Condition Summary: Pheochromocytoma; Paraganglioma

 

Last Updated: 11 Dec 2017

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Lenvatinib in Treating Patients With Metastatic or Advanced Pheochromocytoma or Paraganglioma That Cannot Be Removed by Surgery
 

Status: Recruiting

Condition Summary: Malignant Adrenal Gland Pheochromocytoma; Malignant Paraganglioma; Metastatic Adrenal Gland Pheochromocytoma

 

Last Updated: 14 Nov 2017

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