Mantle cell lymphoma

Common Name(s)

Mantle cell lymphoma

Mantle cell lymphoma (MCL) belongs to a group of diseases known as  non-HodgkinÕs lymphomas (NHL), which are cancers that affect the the lymphatic system (part of the immune system). MCL accounts for 6% of all non-Hodgkin lymphomas and is mostly found in males during their early 60s. Lymphocytes, which are white blood cells that make up the lymphatic system. There are two main types: B-lymphocytes (B-cells) and T-lymphocytes (T-cells). Mantel cell lymphoma is a B-cell lymphoma that develops from cancerous B-cells within a region of the lymph node known as the mantle zone. Although mantle cell lymphomas are slow-growing cancers, at the time of diagnosis, they are usually widespread in the lymph nodes and require intensive treatment because they can become lethal within a short period of time.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mantle cell lymphoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mantle cell lymphoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Mantle cell lymphoma" returned 673 free, full-text research articles on human participants. First 3 results:

Rac1 is a novel therapeutic target in mantle cell lymphoma.
 

Author(s): Tian Tian, Chengfeng Bi, Ashley L Hein, Xuan Zhang, Cheng Wang, Songfei Shen, Ji Yuan, Timothy C Greiner, Charles Enke, Julie Vose, Ying Yan, Kai Fu

Journal:

 

Last Updated: 31 Dec 1969

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Gastrointestinal involvement by mantle cell lymphoma identified by biopsy performed during endoscopy: A case report.
 

Author(s): Qin-Fang Zheng, Jin-Ying Li, Liu Qin, Hai-Ming Wei, Lian-Ying Cai, Bing Nong

Journal: Medicine (Baltimore). 2018 Feb;97(6):e9799.

 

Primary gastrointestinal mantle cell lymphoma is rare, and histopathological examination and specific immunohistochemical staining are still the gold standard for diagnosis. Therefore, it is necessary to find a new way to improve positive biopsy rates.

Last Updated: 31 Dec 1969

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"Double trouble" - synchronous mantle cell lymphoma and metastatic squamous cell carcinoma in an inguinal lymph node.
 

Author(s): Anna Szumera-Ciećkiewicz, Barbara Bikowska-Opalach, Monika Prochorec-Sobieszek

Journal: Pol J Pathol. ;68(3):270-274.

 

Multiple primary neoplasms may also occur synchronously. Lymphoma may coexist with second malignant tumor in its primary location or malignant tumor may metastases to lymphomatous lymph nodes. Most often lymphoid component is a low grade lymphoma and coexistence of mantle cell lymphoma ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Mantle cell lymphoma" returned 58 free, full-text review articles on human participants. First 3 results:

Male breast cancer and mantle cell lymphoma in a single patient: A case report and literature review.
 

Author(s): Jun Liu, Hongquan Wei, Keqing Zhu, Liqin Lai, Xiaoyu Han, Yue Yang

Journal: Medicine (Baltimore). 2017 Dec;96(48):e8911.

 

Although still relatively rare, multiple primary malignant neoplasms (MPMNs) have been increasingly reported in recent years.

Last Updated: 31 Dec 1969

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Smoldering mantle cell lymphoma.
 

Author(s): Haige Ye, Aakash Desai, Dongfeng Zeng, Krystle Nomie, Jorge Romaguera, Makhdum Ahmed, Michael L Wang

Journal:

 

Mantle cell lymphoma (MCL) is an aggressive disease, with poor prognosis and a limited survival. However, some patients with indolent MCL can survive beyond 7~10 years. These patients remain largely asymptomatic and can be in observation for a long time without any treatment. The ...

Last Updated: 31 Dec 1969

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miR-223 is repressed and correlates with inferior clinical features in mantle cell lymphoma through targeting SOX11.
 

Author(s): Keshu Zhou, Xiaoyan Feng, Yanying Wang, Yanyan Liu, Long Tian, Wenli Zuo, Shuhua Yi, Xudong Wei, Yongping Song, Lugui Qiu

Journal: Exp. Hematol.. 2018 02;58():27-34.e1.

 

Mantle cell lymphoma (MCL) is an aggressive lymphoid malignancy characterized by cytogenetic aberration of t(11;14), although it is not the prerequisite. Until now, the pathogenesis of MCL has not been fully interpreted. Our current study showed that microRNA (miR)-223 was downregulated ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Trial of Bortezomib, Cytarabine, and Dexamethasone in Mantle Cell Lymphoma
 

Status: Recruiting

Condition Summary: Mantle Cell Lymphoma

 

Last Updated: 31 Oct 2017

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A Study of Ixazomib and Ibrutinib in Relapsed/Refractory Mantle Cell Lymphoma
 

Status: Recruiting

Condition Summary: Mantle-Cell Lymphoma

 

Last Updated: 14 Aug 2018

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Last Updated: 9 Jan 2017

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