Marchiafava Bignami disease

Common Name(s)

Marchiafava Bignami disease

Marchiafava Bignami disease is defined by characteristic demyelination of the corpus callosum (erosion of the protective covering of nerve fibers joining the 2 hemispheres of the brain). The disease seems to most often affect severe and chronic alcoholics in their middle or late adult life. Early symptoms may include depression, paranoia, psychosis, or dementia. Seizures are common, and hemiparesis, aphasia, abnormal movements, and ataxia may sometimes progress to coma and/or death. The cause of Marchiafava Bignami disease, including the potential role of nutritional deficiency, is unknown. Improvement and recovery of some individuals has been reported.  Treatment focuses on nutritional support and rehabilitation from alcoholism.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Marchiafava Bignami disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Marchiafava Bignami disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Marchiafava Bignami disease" returned 32 free, full-text research articles on human participants. First 3 results:

Simultaneous acute Marchiafava-Bignami disease and central pontine myelinolysis: A case report of a challenging diagnosis.
 

Author(s): Chun-Yi Tsai, Po-Kai Huang, Poyin Huang

Journal: Medicine (Baltimore). 2018 Feb;97(8):e9878.

 

Marchiafava-Bignami disease (MBD) is a rare disease characterized by demyelination of the corpus callosum. It is most commonly seen in patients with chronic alcoholism. The clinical diagnosis of MBD can be difficult due to its nonspecific manifestation. Central pontine myelinolysis ...

Last Updated: 31 Dec 1969

Go To URL
Clinical and radiological features of Marchiafava-Bignami disease.
 

Author(s): Xiaoyu Dong, Chaobo Bai, Jianfei Nao

Journal: Medicine (Baltimore). 2018 Feb;97(5):e9626.

 

Marchiafava-Bignami disease (MBD) is a rare neurological disease usually associated with chronic alcoholism and characterized by demyelination and necrosis. Our aims were to describe the clinicoradiological features and identify factors that may affect the prognosis of patients with ...

Last Updated: 31 Dec 1969

Go To URL
[Marchiafava-Bignami disease (Case-report)].
 

Author(s): Gyorgy Pinter, Krisztina Borbely, Laszlo Peter

Journal: Neuropsychopharmacol Hung. 2016 06;18(2):115-8.

 

Marchiafava-Bignami disease (MBD) is caused by damage of the corpus callosum. There are acute, subacute and chronic forms, it occurs most frequently among alcoholic patients. A variety of neurological symptoms, epileptic seizures, and coma may be associated with the disease, but the ...

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Marchiafava Bignami disease" returned 2 free, full-text review articles on human participants. First 3 results:

Diagnosis and management of Marchiafava-Bignami disease: a review of CT/MRI confirmed cases.
 

Author(s): Matti Hillbom, Pertti Saloheimo, Shinsuke Fujioka, Zbigniew K Wszolek, Seppo Juvela, Maurizio A Leone

Journal: J. Neurol. Neurosurg. Psychiatry. 2014 Feb;85(2):168-73.

 

Marchiafava-Bignami disease (MBD) is a rare condition mainly associated with alcoholism, although it may be mimicked by several other disorders that cause corpus callosum lesions. Our objective was to identify helpful features for differential diagnosis and assess whether any treatment ...

Last Updated: 31 Dec 1969

Go To URL
Cortical involvement in Marchiafava-Bignami disease can be a predictor of a poor prognosis: a case report and review of the literature.
 

Author(s): Michito Namekawa, Yuko Nakamura, Imaharu Nakano

Journal: Intern. Med.. 2013 ;52(7):811-3.

 

Marchiafava-Bignami disease (MBD) is a rare alcohol-associated disorder characterized by demyelination and necrosis of the corpus callosum. We herein present the case of a 56-year-old man with chronic alcoholism who was admitted to our hospital in a coma without focal or lateralizing ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.