Mast cell disease

Common Name(s)

Mast cell disease, Mastocytosis

Mastocytosis is a disorder that can occur in both children and adults. It is caused by the presence of too many mast cells in the body. Mast cells contain substances such as histamine that regulate allergic reactions. Signs and symptoms of mastocytosis may include musculoskeletal pain, abdominal discomfort, nausea, vomiting, ulcers, diarrhea, and skin lesions. Treatment may include medications such as antihistamines (to prevent the effect of mast cell histamine) and anticholinergics (to relieve intestinal cramping).

There are two broad categories of mastocytosis, cutaneous and systemic. Cutaneous mastocytosis only affects the skin and is usually diagnosed in children. Systemic mastocytosis affects more than one part of the body and is usually diagnosed in adults. GARD provides additional information on cutaneous mastocytosis and systemic mastocytosis.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mast cell disease" for support, advocacy or research.

Ehlers-Danlos Support UK

EDS UK was set up in 1987 to support, advise and inform those living with Ehlers-Danlos Syndrome. We aim to help them live a full, active and positive life. Over 25 years later, we remain the only UK based charity that exclusively represents and supports people with all types of EDS. We run regular events and conferences to bring our community together, and produce literature and merchandise to increase understanding and improve management of the condition. We have over 30 support groups around the country to provide our members with a local peer support network and we hope to expand this

Last Updated: 17 Aug 2015

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The Mastocytosis Society, Inc

The Mastocytosis Society is a 501(c)3 nonprofit organization dedicated to supporting patients affected by Mastocytosis or Mast Cell Activation Disorders as well as their families, caregivers, and physicians through research, education, and advocacy.

Last Updated: 20 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mast cell disease" for support, advocacy or research.

Ehlers-Danlos Support UK

EDS UK was set up in 1987 to support, advise and inform those living with Ehlers-Danlos Syndrome. We aim to help them live a full, active and positive life. Over 25 years later, we remain the only UK based charity that exclusively represents and supports people with all types of EDS. We run regular events and conferences to bring our community together, and produce literature and merchandise to increase understanding and improve management of the condition. We have over 30 support groups around the country to provide our members with a local peer support network and we hope to expand this

http://www.ehlers-danlos.org

Last Updated: 17 Aug 2015

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The Mastocytosis Society, Inc

The Mastocytosis Society is a 501(c)3 nonprofit organization dedicated to supporting patients affected by Mastocytosis or Mast Cell Activation Disorders as well as their families, caregivers, and physicians through research, education, and advocacy.

http://www.TMSforacure.org

Last Updated: 20 Nov 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Mast cell disease" returned 41 free, full-text research articles on human participants. First 3 results:

Expressions of Mast Cell Tryptase and Brain Natriuretic Peptide in Myocardium of Sudden Death due to Hypersensitivity and Coronary Atherosclerotic Heart Disease.
 

Author(s): J R Shi, C J Tian, Q Zeng, X J Guo, J Lu, C R Gao

Journal: Fa Yi Xue Za Zhi. 2016 Jun;32(3):161-164.

 

To explore the value of mast cell tryptase and brain natriuretic peptide(BNP) in the differential diagnostic of sudden death due to hypersensitivity and coronary atherosclerotic heart disease.

Last Updated: 31 Dec 1969

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The Impact of Mast Cell Density on the Progression of Bone Disease in Multiple Myeloma Patients.
 

Author(s): Rodanthi Vyzoukaki, George Tsirakis, Constantina A Pappa, Maria Devetzoglou, Maria Tzardi, Michael G Alexandrakis

Journal: Int. Arch. Allergy Immunol.. 2015 ;168(4):263-8.

 

Osteolytic bone disease is a major hallmark in multiple myeloma (MM) progression and affects many patients. Several inflammatory cells are involved in MM progression. Among them, mast cells (MCs) accumulated in the bone marrow (BM) microenvironment are known to play an important role ...

Last Updated: 31 Dec 1969

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Aspirin-Exacerbated Respiratory Disease Involves a Cysteinyl Leukotriene-Driven IL-33-Mediated Mast Cell Activation Pathway.
 

Author(s): Tao Liu, Yoshihide Kanaoka, Nora A Barrett, Chunli Feng, Denise Garofalo, Juying Lai, Kathleen Buchheit, Neil Bhattacharya, Tanya M Laidlaw, Howard R Katz, Joshua A Boyce

Journal: J. Immunol.. 2015 Oct;195(8):3537-45.

 

Aspirin-exacerbated respiratory disease (AERD), a severe eosinophilic inflammatory disorder of the airways, involves overproduction of cysteinyl leukotrienes (cysLTs), activation of airway mast cells (MCs), and bronchoconstriction in response to nonselective cyclooxygenase inhibitors ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Mast cell disease" returned 10 free, full-text review articles on human participants. First 3 results:

A Practical Guide for Treatment of Pain in Patients with Systemic Mast Cell Activation Disease.
 

Author(s): Stefan Wirz, Gerhard J Molderings

Journal: Pain Physician. 2017 Sep;20(6):E849-E861.

 

Systemic mast cell activation disease (MCAD, a subclass of mastocytosis), which has a prevalence of around 17% (at least in the German population), is characterized by accumulation of genetically altered dysfunctional mast cells with abnormal release of these cells' mediators. Since ...

Last Updated: 31 Dec 1969

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Pharmacological treatment options for mast cell activation disease.
 

Author(s): Gerhard J Molderings, Britta Haenisch, Stefan Brettner, Jürgen Homann, Markus Menzen, Franz Ludwig Dumoulin, Jens Panse, Joseph Butterfield, Lawrence B Afrin

Journal: Naunyn Schmiedebergs Arch. Pharmacol.. 2016 Jul;389(7):671-94.

 

Mast cell activation disease (MCAD) is a term referring to a heterogeneous group of disorders characterized by aberrant release of variable subsets of mast cell (MC) mediators together with accumulation of either morphologically altered and immunohistochemically identifiable mutated ...

Last Updated: 31 Dec 1969

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The multifaceted mast cell in inflammatory bowel disease.
 

Author(s): Matthew J Hamilton, Sandra M Frei, Richard L Stevens

Journal: Inflamm. Bowel Dis.. 2014 Dec;20(12):2364-78.

 

Mast cells (MCs) are tissue-resident immune cells that carry out protective roles against pathogens. In disease states, such as inflammatory bowel disease, these granulocytes release a diverse array of mediators that contribute to inflammatory processes. They also participate in wound ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Diagnostic Value of Bone Marrow Tryptase in Systemic Mastocytosis
 

Status: Recruiting

Condition Summary: Systemic Mastocytosis

 

Last Updated: 25 Jan 2018

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Cladribine Plus Pegylated Interpheron Alfa-2a in Systemic Mastocytosis
 

Status: Recruiting

Condition Summary: Systemic Mastocytosis

 

Last Updated: 26 Aug 2016

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Mast Cell Connect: A Registry for Patients With Mastocytosis
 

Status: Recruiting

Condition Summary: Mastocytosis

 

Last Updated: 19 Sep 2017

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